Clinical trials: Large Language Models
Complete Blood Count Review
Multi-center Validation Study of a Large Language Model-based Intelligent Agent for Blood Cell Analysis
I. Study Background: Currently, in most medical institutions, the review of blood cell analysis still heavily relies on manual verification by laboratory staff.
- Trial name
- NCT07607184
- Testing
- LLM-Assisted Review Group
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
TCM Constitution Theory
Research on an Intelligent Health Recommendation System for Chronic Disease Comorbidity Integrating TCM
1. Construct a Traditional Chinese Medicine (TCM) constitution database, clarify the distribution patterns of TCM constitution in populations with comorbid "three-high" conditions (hypertension, hyperlipidemia, and hyperglycemia)…
- Trial name
- NCT07308366
- Testing
- Multimodal AI Models
- Volunteers
- 195 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Myopia, Large Language Model
Development and Validation of a Large Language Model-based Myopia Assistant System
Myopia is a rapidly growing global health concern, and there is an urgent need for advanced tools that can facilitate personalized healthcare strategies.
- Trial name
- NCT06607822
- Testing
- A patient-centered assistant system based on Large-Language Model (LLM)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
All Conditions
Can Feedback From a Large Language Model Improve Health Care Quality?
The goal of this study is to learn if computer-assisted advice can help improve patient care in Nigerian health clinics. The main question it aims to answer is: does giving healthcare workers instant computer feedback help them…
- Trial name
- NCT06823765
- Testing
- Large Language Model Clinical Decision Support
- Where
- 2 sites in Nigeria
- Volunteers
- 491 people
- Sponsor
- Yale University
Tobacco Use, Smoking Cessation
Chatbot Counselling for Smoking Cessation in Youths
The goal of this pilot trial is to develop and examine the trial feasibility and acceptability of a chatbot for smoking cessation in youth smokers. Specific aims include: 1.
- Trial name
- NCT06470776
- Testing
- Chatbot counselling, Peer counselling
- Where
- Hong Kong
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Clinical Decision-making
Physician Reasoning on Management Cases With Large Language Models
This study will evaluate the effect of providing access to GPT-4, a large language model, compared to traditional management decision support tools on performance on case-based management reasoning tasks.
- Trial name
- NCT06208423
- Testing
- GPT-4
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diagnosis
Physician Reasoning on Diagnostic Cases With Large Language Models
This study will evaluate the effect of providing access to GPT-4, a large language model, compared to traditional diagnostic decision support tools on performance on case-based diagnostic reasoning tasks.
- Trial name
- NCT06157944
- Testing
- GPT-4
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cancer, Respiratory Failure
Multi-Disciplinary Treatment on the Anthropomorphism of Large Language Models
This retrospective clinical trial aims to better explore the potential of large language models in medicine by comparing the effectiveness of MDT consultations conducted by human doctors with those conducted by large language…
- Conditions
- Cancer, Respiratory Failure, Heart Diseases, Infections
- Trial name
- MDTALLM (NCT06627985)
- Testing
- GPT-4o, GPT-4o mini, MedicalGPT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- North Sichuan Medical College
Emergency Care, Clinical Decision Support
Artificial Intelligence(AI) in the Emergency Department (ED) in Cologne
This retrospective, non-interventional study evaluates the prognostic performance of open-weight Large Language Models (LLMs) in the setting of a German academic emergency department.
- Conditions
- Emergency Care, Clinical Decision Support, Triage
- Trial name
- KINA-CO (NCT07725965)
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- University of Cologne
Ophthalmic Diseases (Specific Types Not Restricted)
Research on the Real-World Community Application of Large Language Models
There is an imbalance between the supply and demand of eye care services, especially in local communities and remote areas. To address this, it's important to use new intelligent technologies to expand the reach of eye disease…
- Trial name
- NCT06966882
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Kidney Transplantation
Performances of Large Language Models in Kidney Allograft Diagnostics
Kidney allograft rejection diagnosis relies on the complex Banff classification, but its application is limited by variability and workload.
- Trial name
- NCT07004660
- Volunteers
- 240 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Peritoneal Dialysis (PD), Large Language Models
Peritoneal Dialysis (PD) Specialized LLM for PD Management
This study conducted a randomized controlled trial using clinical vignettes to evaluate differences in the quality of PD management among two large language model-assisted workflows and a physician-only decision-making process…
- Trial name
- PIONEER-PD (NCT07539428)
- Testing
- Peritoneal dialysis-specialized large language model., Generalized LLM tools such as deepseek
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Diagnosis
Evaluation of a Retrieval Augmented Large Language Model as a Diagnostic Copilot in Rheumatology
This trial evaluates whether providing physicians with access to Prof. Valmed, a clinical decision support medical product, improves identification of rheumatic diseases and formulation of differential diagnoses compared with…
- Trial name
- ALLIANCE (NCT07166692)
- Testing
- Prof. Valmed
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Cervical Cancer
Multi-agent LLMs for Decision Support in Cervical Cancer During Pregnancy
The aim of this study is to develop an AI-assisted decision-making system based on multi-agent large language models and to evaluate its effectiveness and accuracy in the diagnosis and treatment of cervical cancer during…
- Trial name
- NCT07318701
- Testing
- multi-disciplinary agents group, real MDT group, junor doctor group
- Volunteers
- 150 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
The Emergency Response Capabilities of Nurses (Including Occupational Protection, Critical Thinking, Communication Skills and Humanistic Care, Etc.)
Development and Evaluation of a Large Language Model - Based Training Program for Nurses in Public Health Emergencies
The goal of this randomized controlled trial is to evaluate the immediate efficacy of a Large Language Model (LLM)-assisted training program in enhancing nurses' emergency response capabilities in 204 practicing nurses with ≤5…
- Trial name
- NCT07141433
- Testing
- LLM-Assisted Public Health Emergency Training Program, Standard Public Health Emergency Training Program
- Where
- China
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
HPV Vaccination Rates, HPV Vaccine Awareness
Effectiveness of Large Language Model-Based Chatbot Among Parents of Junior High School Girls in Improving Human Papillomavirus (HPV) Vaccine Awareness, Intention and Vaccination Rates
This is an interventional study targeting parents of junior high school girls. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates among parents' junior high…
- Conditions
- HPV Vaccination Rates, HPV Vaccine Awareness, HPV Vaccination Intention
- Trial name
- NCT07525245
- Testing
- Scientific videos, Vaccine chatbot
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Self-Directed Learning, Artificial Intelligence
ChatGPT Helping Advance Training for Medical Students: A Study on Self-Directed Learning Enhancement
The goal of this clinical trial is to evaluate the effect of LearnGuide, a custom GPT developed with ChatGPT for supporting self-directed learning (SDL) in medical students.
- Conditions
- Self-Directed Learning, Artificial Intelligence, Medical Education
- Trial name
- CHAT-MS (NCT06276049)
- Testing
- custom GPT supported self-directed learning
- Where
- China
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Wang Shalong
Radiology, Artificial Intellegence
Chest X-Ray Image Diagnosis and Report Generation Dedicated Model Based on Deepseek
The global shortage of radiologists is a pressing issue, particularly in regions with limited medical resources. Against this backdrop, making report generation the core objective of radiology AI systems not only aligns with the…
- Conditions
- Radiology, Artificial Intellegence, Large Language Model, Chest X-ray for Clinical Evaluation
- Trial name
- NCT06874647
- Testing
- AI-generated report for reference
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Dental Education, Artificial Intelligence (AI)
AI Virtual Patient Training for Dental Student History Taking
This randomized study evaluated whether an artificial intelligence-assisted virtual patient could support third-year dental students in practicing medical and dental history taking.
- Conditions
- Dental Education, Artificial Intelligence (AI), Virtual Patient, History Taking
- Trial name
- NCT07688668
- Testing
- Gemini-Based AI Virtual-Patient Training, Conventional Role-Play Training
- Where
- Vietnam
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hue University of Medicine and Pharmacy
Diagnosis
Automation Bias in Physician-LLM Diagnostic Reasoning
This study aims to systematically measure the extent and patterns of automation bias among physicians when utilizing ChatGPT-4o in clinical decision-making.
- Trial name
- NCT06963957
- Testing
- ChatGPT-4o Recommendations with Hallucinations
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences