Clinical trials: Late Effects
Premature Birth, Asthma in Children
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental…
- Conditions
- Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
- Trial name
- NCT05336890
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Stem Cell Transplant, Stem Cell Transplantation
Fertility Protection for Children, Adolescents and Young Adults
This study focuses on improving fertility preservation and long-term care for children, adolescents, and young adults (CAYA) undergoing cancer treatments or stem cell transplantation.
- Conditions
- Stem Cell Transplant, Stem Cell Transplantation, Oncological Outcomes, Oncological Patients
- Trial name
- FeProCAYA (NCT06692868)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Ulm
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases, Heart Diseases
Electrophysiological Effects of Late PCI After MI
The purpose of this study is to determine if opening blocked arteries with heart balloons and stents prevents heart rhythm problems in individuals 3 to 28 days after a heart attack.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Coronary Disease
- Trial name
- NCT00119847
- Testing
- PCI, Optimal Medical Therapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Maryland, Baltimore
Long-term Effects Secondary to Cancer Therapy in Children, Pulmonary Complications
Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.
- Trial name
- NCT00009711
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Fred Hutchinson Cancer Center
Preterm Birth, Periventricular Leukomalacia
Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth
Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational…
- Conditions
- Preterm Birth, Periventricular Leukomalacia, Brain Ischemia, Intracranial Hemorrhages
- Trial name
- NCT00120588
- Testing
- magnesium
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Rouen
Anemia, Iron Deficiency
Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
The investigators plan a study to randomize 540 children in Nepal to early (≤30 seconds) or late (≥180 seconds) clamping of the umbilical cord at birth.
- Conditions
- Anemia, Iron Deficiency, Neonatal Jaundice
- Trial name
- NCT02222805
- Testing
- Early (≤30 seconds) cord clamping, Delayed (≤180 seconds) cord clamping
- Where
- Nepal
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy.
- Trial name
- NCT00003070
- Testing
- enalapril maleate, quality-of-life assessment
- Where
- 61 sites in United States, Canada and 1 more
- Volunteers
- 13 people
- Sponsor
- Children's Oncology Group
Pediatric or Young Adult Cancer Survivors
Prospective Ascertainment for Late Effects Among Survivors of Cancer, Tumor, or a Related Illness
The purpose of this study is to establish a registry of survivors of cancer, tumor, or a related illness.
- Trial name
- NCT01667952
- Testing
- Family History Questionnaire (FHQ), Salvia sample, Blood sample
- Where
- United States
- Volunteers
- 1,068 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stroke, Stroke, Acute
Data Collection of Patients Admitted to the Stroke Unit
The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- PRODA-STROKE (NCT04956185)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Ghent
HIV Infections, HIV Seronegativity
Long-Term Effects of HIV Exposure and Infection in Children
As new drugs and vaccines are developed to prevent HIV disease progression and prolong survival of HIV infected patients, the short-term safety and effectiveness of these treatments are evaluated in research studies.
- Trial name
- NCT00006304
- Where
- 92 sites in United States, Puerto Rico
- Volunteers
- 4,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Premature Birth
Cleanser Versus Only Water
The aim of this study is to determine the effect of the newborn's first bath with a cleaning product and only water on the barrier function of the skin.
- Trial name
- NCT04720989
- Testing
- Bathing With Baby Cleanser and water, Bathing With only Water
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Chronic Graft-versus-Host-Disease, Leukemia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults…
- Conditions
- Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer
- Trial name
- NCT04372524
- Where
- 16 sites in United States, Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Impacted Third Molar Tooth
Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus
The present study was to evaluate the effect of topical Arnica and MPSP application with respect to visual analogue scale (VAS) scores, maximal interincisal opening (MIO) and edema values after mandibular impacted third molar…
- Trial name
- NCT04534426
- Testing
- : Arnica montana, Mucopolysaccharide polysulfate, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Bronchopulmonary Dysplasia, Chronic Pulmonary Insufficiency of Prematurity
Late Surfactant After a Recruitment Maneuver in Extremely Low Gestational Age Newborns - LATE-REC-SURF Trial
This is an unblinded monocentric pilot superiority trial that will be conducted in a IIIlevel NICU at Fondazione Policlinico Agostino Gemelli - IRCCS.
- Trial name
- LateRecSurf (NCT04825197)
- Testing
- Poractant Alfa Intratracheal Suspension [Curosurf]
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- VENTO GIOVANNI
Weight Loss
The Outcome of Abdominoplasty After Massive Weight Loss
The primary aim of this study is to compare early surgical complications after abdominoplasty performed by plastic and general surgeons.
- Trial name
- NCT02679391
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Quality of Life, Sequela
Patient's Quality of Life Assessment 5 to 10 Years After Hospitalization in Intensive Care Unit for a Severe Bacterial Infection
The aim of this study is to assess patient's quality of life 5 to 10 years after a severe bacterial infection with hospitalization in a intensive unit care. The population is derived from the DIABACT III study.
- Trial name
- NCT04005560
- Testing
- no interventional study
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Nantes University Hospital
Cerebral Palsy Hypoxic-Ischemic Encephalopathy Intracranial Hemorrhage
Autologous Bone Marrow Mononuclear Cell Transplantation Combined With Rehabilitation in Children With Sequelae of Hypoxic-Ischemic Encephalopathy or Intracranial Hemorrhage
This study evaluates the safety and preliminary efficacy of autologous bone marrow mononuclear cell transplantation combined with rehabilitation in children with neurological sequelae caused by hypoxic-ischemic brain injury or…
- Trial name
- BMMCT-CP (NCT07527104)
- Testing
- Autologous Bone Marrow Mononuclear Cell Transplantation
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- National Children's Hospital, Vietnam
Sarcoma
Late Effects of Treatment for Sarcomas in Children
This study will examine late effects of treatment for sarcoma (bone and soft tissue cancers) in children. Survival of patients with these diseases has improved over the years, but long-term adverse effects of treatment have also…
- Trial name
- NCT00006515
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Carbon Monoxide Poisoning
Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning
The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.
- Trial name
- NCT04925297
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,250 people
- Sponsor
- The First Hospital of Jilin University