Clinical trials: Leishmaniasis, Mucocutaneous
Leishmaniasis
Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis
Miltefosine (longer course) will be used to try to improve the cure rate of mucosal leishmaniasis
- Trial name
- NCT00373568
- Testing
- miltefosine: 2.5 mg/kg/day for 42 days
- Where
- Bolivia
- Volunteers
- 25 people
- Sponsor
- AB Foundation
Cutaneous Leishmaniasis, American
Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis
Cure rate for L braziliensis bolivian CL has been 70%-80% for standard systemic and local monotherapies. It would benefit patients if cure rates could be consistently >90%, so testing a combination of two treatments is proposed.
- Trial name
- NCT03829917
- Testing
- Miltefosine and Paromomycin, miltefosine, paromomycin
- Where
- Bolivia
- Volunteers
- 120 people
- Sponsor
- Fundacion Nacional de Dermatologia
Kinetoplastid, Skin Diseases, Parasitic
Diagnosis and Treatment of Leishmania Infections
Patients admitted on this protocol must have an active Leishmania infection. The major objectives of the protocol are to diagnose and classify the Leishmania infection and to provide species-based therapy to study the natural…
- Conditions
- Kinetoplastid, Skin Diseases, Parasitic, Parasitic Diseases, Leishmaniasis
- Trial name
- NCT00344188
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mucosal Leishmaniasis, Mucocutaneous Leishmaniasis
Low Antimonial Dosage in American Mucosal Leishmaniasis
"Phase III clinical trial for mucosal or mucocutaneous leishmaniasis. Equivalence between the standard and alternative schemes with meglumine antimoniate" has begun in October 2008 at the Laboratory of Leishmaniasis Surveillance…
- Trial name
- NCT01301937
- Testing
- Meglumine antimoniate
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Oswaldo Cruz Foundation
Leishmaniasis
Miltefosine for Mucosal Leishmaniasis
This trial will study miltefosine as a treatment for mucosal leishmaniasis.
- Trial name
- NCT00373776
- Testing
- miltefosine 2.5 mg/kg/day for 28 days
- Where
- Bolivia
- Volunteers
- 75 people
- Sponsor
- AB Foundation
Mucosal Leishmaniasis
Treatment of Mucosal Bolivian Leishmaniasis
The purpose of this protocol is to conduct a randomized comparison of the efficacy and tolerance of miltefosine, LAMB, and pentavalent antimony for the treatment of mucosal leishmaniasis.
- Trial name
- NCT04799236
- Testing
- Group 1: Miltefosine, Group 2: Pentavalent Antimony, Group 3: Liposomal amphotericin B
- Where
- Bolivia
- Volunteers
- 120 people
- Sponsor
- Fundacion Nacional de Dermatologia
Leishmaniasis, Leishmaniasis, Mucocutaneous
Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis
The purpose of this study is to determine whether miltefosine is effective in the treatment of mucosal leishmaniasis compared to meglumine antimoniate, the standard treatment.
- Trial name
- NCT01377974
- Testing
- Miltefosine, Standard Treatment Meglumine antimoniate
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia University Hospital
Leishmania Infantum Disease, Leishmaniasis, Visceral
LEISH-PED: Study on Leishmaniasis in Children
Leishmaniasis is an infection caused by Leishmania parasites. In children, it can affect the skin or internal organs. Diagnosis may be delayed because the signs and symptoms can be similar to those of other conditions.
- Conditions
- Leishmania Infantum Disease, Leishmaniasis, Visceral, Leishmaniasis, Cutaneous, Leishmaniasis, Mucocutaneous
- Trial name
- LEISH-PED (NCT07504757)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Meyer Children's Hospital IRCCS
Mucosal Leishmaniasis
Treatment of Bolivian L Braziliensis Mucosal Leishmaniasis With Inhaled Pentamidine Plus Oral Miltefosine
This is a phase 2 study of the combination of inhaled-pentamidine plus oral miltefosine for Bolivian mucosal leishmaniasis.
- Trial name
- NCT06550609
- Testing
- Miltefosine Oral Capsule
- Where
- Bolivia
- Volunteers
- 30 people
- Sponsor
- Fundacion Nacional de Dermatologia
Cutaneous Leishmaniasis, American
Feasibility and Usability of Mobile Applications for Monitoring Cutaneous Leishmaniasis Treatment in Colombia
An effectiveness-implementation sequential explanatory hybrid design type 2 was performed in two rural communities of Colombia. A quasi-experimental study with historical control (standard of care) was designed to estimate the…
- Trial name
- NCT05533736
- Testing
- Community based strategy to follow-up pactientes with Cutaneous Leishmaniasis
- Where
- Colombia
- Volunteers
- 105 people
- Sponsor
- Centro Internacional de Entrenamiento e Investigaciones Médicas
Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex
Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
This protocol will compare topical paromomycin to standard intralesional (IL) antimony (Sb) to placebo for L braziliensis in Bolivia.
- Conditions
- Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex, Leishmaniasis, American, Leishmaniasis; American, Cutaneous
- Trial name
- NCT03096457
- Testing
- Paromomycin Sulfate, Pentamidine Isethionate
- Where
- 2 sites in Bolivia
- Volunteers
- 80 people
- Sponsor
- Fundacion Nacional de Dermatologia