Clinical trials: Localized Infection
Health Risk Behaviors
Sexually Active Adolescent Focused Education
SAAFE will be pilot tested in 2 geographically distinct areas (Washington, DC and Deep South) with 100 participants from each site to 1) primarily assess the efficacy of improved self-efficacy, knowledge about HIV/STIs and…
- Trial name
- SAAFE (NCT03646032)
- Testing
- SAAFE, Control
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Benten Technologies, Inc.
Influenza
TIV Infant/Toddler Response Evaluation (TITRE)- Follow-up & Focus on Influenza B
Each winter, viruses belonging to two kinds of influenza A ("A/H1N1" \& "A/H3N2") and two kinds of influenza B ("B/Yamagata" \& "B/Victoria") can cause illness.
- Trial name
- TITRE II (NCT01067404)
- Testing
- Trivalent inactivated influenza vaccine
- Where
- 3 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- British Columbia Centre for Disease Control
IPV, HIV
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
This study will test the effectiveness of a youth-designed multilevel intervention, Tu'Washindi, to increase PrEP use and reduce intimate partner violence (IPV) among Kenyan AGYW and to identify implementation challenges and…
- Conditions
- IPV, HIV, PrEP
- Trial name
- NCT05599581
- Testing
- Tu'Washindi
- Where
- 2 sites in Kenya
- Volunteers
- 1,562 people, healthy volunteers welcome
- Sponsor
- RTI International
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Malaria
Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland
This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on…
- Trial name
- fMDA (NCT02315690)
- Testing
- dihydroartemisinin-piperaquine (DHAp), reactive case detection
- Where
- Eswatini
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contraception
Evaluation of a Peer Education Program to Promote Family Planning Among Female Sex Workers in Kenya
-Purpose: To develop and evaluate an intervention designed to improve consistent contraceptive use and dual method use in particular, among female sex workers (FSWs) in Rift Valley Province in Kenya.
- Trial name
- NCT01957813
- Testing
- Lifestyle Counseling, Standard Health Services
- Where
- 2 sites in Kenya
- Volunteers
- 719 people, healthy volunteers welcome
- Sponsor
- FHI 360
Epilepsy Syndrome
Cognitive Impairments in Children With Epilepsy
Since the proportion of language and attentional difficulties in patients with epilepsy is recognized, both in the literature and in the clinical experience of practitioners, it is appropriate to propose a complete…
- Trial name
- NCT05097742
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Malaria Prevention
Focal Mass Drug Administration for the Prevention of Malaria in Pregnancy
The purpose of this study is to demonstrate the feasibility, acceptability, and preliminary effectiveness of a focal mass drug administration program for household members of pregnant women to protect against malaria in pregnancy.
- Trial name
- NCT07021430
- Testing
- Dihydroartemisinin Piperaquine
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis, Pulmonary, Mycobacterium Tuberculosis Infection
Clinic-based Versus Hotspot-focused Active TB Case Finding
This five-year study will evaluate two strategies for conducting tuberculosis (TB) active case finding (ACF) and linkage to TB treatment or TB preventive therapy (TPT) in peri-urban Uganda.
- Trial name
- CHASE-TB (NCT05285202)
- Testing
- Active TB case finding with linkage to preventive therapy (ACF/TPT)
- Where
- Uganda
- Volunteers
- 146,539 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Hiv, Sexual Health
Parent-focused Intervention to Reduce HIV Risk in Gay and Bisexual Adolescents
Gay and bisexual youth make up 80% of all new HIV infections among adolescents ages 14-19 in the United States, yet interventions to improve sexual health outcomes in these youth are extremely limited.
- Trial name
- NCT05852600
- Testing
- Parents and Adolescents Talking about Healthy Sexuality (PATHS), Lead with Love (LWL)
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- George Washington University
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in Thailand
This study assesses the effectiveness of reactive focal mass drug administration (rfMDA), targeting both village and forest working populations, compared to control for reducing the health promotion hospital-level (sub-district)…
- Trial name
- COMBAT (NCT05052502)
- Testing
- Case Management and Follow-up, Reactive focal mass drug administration (rfMDA)
- Where
- Thailand
- Volunteers
- 14,977 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia
This is a cluster randomised controlled trial with factorial study design comparing the impact of reactive community-based malaria interventions: 1) presumptive treatment (or rfMDA, reactive focal mass drug administration) versus…
- Trial name
- NCT02610400
- Testing
- RACD, RAVC, rfMDA
- Where
- Namibia
- Volunteers
- 9,845 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Virus Diseases
Post-COVID-19 Monitoring in Routine Health Insurance Data With Focus on Autoimmune Diseases (POINTED-AD)
The SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) infection was in 2020 responsible for new disease related chronic conditions which have been referred to as Post-COVID.
- Trial name
- POINTED-AD (NCT05606198)
- Testing
- Exposed to a SARS-CoV-2 infection
- Where
- Germany
- Volunteers
- 641,407 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
The Study Focused on the Safety of Inactivated EV71 Vaccine (Human Diploid Cell) Against Hand, Foot and Mouth Disease in Chinese Children and Infants
A Phase II, Safety and Efficacy Study of Inactivated EV 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants
Enterovirus 71 (EV71), a major pathogen that is responsible for causing hand-foot-and-mouth disease (HFMD) worldwide, is a member of the Human Enterovirus species A, family Picornaviridae.
- Trial name
- NCT01512706
- Testing
- 160Eu/0.5ml in infants (6-11 months old), 320Eu/0.5ml in infants (6-11 months old), 640Eu/0.5ml in infants (6-11 months old)
- Where
- China
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Focal Infection, Dental
Immediate Versus Delayed Treatment of Odontogenic Infections
The objective of this study is to compare the physiologic resolution of dental infections between immediate tooth extraction (control group) and administration of systemic antibiotics and delayed extraction (study groups 1 and…
- Trial name
- NCT04057014
- Testing
- Amoxicillin, Tooth extraction
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
SARS CoV-2, Developmental Disorder
Neurological Development In Toddlers After Maternal SARS-CoV-2 Infection During Pregnancy
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a virus that causes neurological symptoms in a significant proportion of patients in addition to respiratory symptoms.
- Conditions
- SARS CoV-2, Developmental Disorder, Pregnancy Related
- Trial name
- CRONOS-Kids (NCT06968897)
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Infection, Bacterial, Antibiotic Resistant Infection
Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.
Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage.
- Conditions
- Infection, Bacterial, Antibiotic Resistant Infection, Diagnostic Self Evaluation, Meningitis, Bacterial
- Trial name
- NCT03252028
- Where
- 2 sites in Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fariba Nayeri
Schistosomiasis
Women and Children as the Focus for Control of Schistosomiasis Infections in the Irrigations Area of Burkina Faso
The purpose of this study is to examine the extent of schistosomasis infections in women and children, their daily activites that encumber contact with water and their knowledge and attitudes towards the prevention of…
- Trial name
- NCT00463528
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development