Clinical trials: Longevity
Osteoarthritis, Knee, Osteoarthritis, Hip
Improving Resilience and Longevity for Workers Through Exercise
The purpose of this study is to examine the impact of an OA-specific aerobic and strengthening exercise program, delivered within the workplace, on mobility, pain, physical capacity, and resilience among workers with knee or hip…
- Trial name
- NCT03050320
- Testing
- Exercise, No Exercise
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperlipidemias, Diabetes
Social Needs Screening and Chronic Diseases Study (WE CARE)
The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful…
- Conditions
- Hyperlipidemias, Diabetes, Depression, Pediatric Asthma
- Trial name
- NCT06903897
- Testing
- WE CARE SDOH System, Standard Pediatric Care
- Where
- 3 sites in United States
- Volunteers
- 68,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Metabolic Disease, Cardiovascular Diseases
Zhejiang Nutrition and Health Study
This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups.
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Healthy Aging
- Trial name
- NuLife (NCT05930717)
- Where
- 2 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
ADHD
Investigating Health, Equity, and Resilience in Girls and Women With ADHD Across the Lifespan
The goal of this observational study is to generate a comprehensive, multi-dimensional dataset of health indicators collected from girls and women (aged 10 years and older) with and without ADHD across the lifespan.
- Trial name
- ADHD-Her (NCT07597707)
- Testing
- No Intervention: Observational Cohort
- Where
- Canada
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Dental Caries
SEALANT-DK: Longevity and Efficacy of 6 Resin Sealants Used for Sealing Permanent Teeth in Children and Adolescents
Background: Occlusal caries is the main reason for restorative therapy in the young permanent dentition, but restorations have limited survival time and may also weaken the tooth.
- Trial name
- SEALANT-DK (NCT02561689)
- Testing
- Fissure sealing
- Where
- Denmark
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dental Caries
Sealing Manifest Occlusal Caries Lesions in the Permanent Dentition
The research project "SEAL-DK" is focusing on advantages and disadvantages of two treatment strategies: non-invasive fissure sealing and invasive restorative treatment of manifest occlusal caries lesions in permanent teeth in…
- Trial name
- SEAL-DK (NCT02573090)
- Testing
- Non-invasive resin based fissure sealing, Invasive resin based restoration
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Autism
Sensory Phenotypes of Autism Spectrum Disorder
This project plans to establish sensory phenotypes of a Taiwanese ASD cohort across lifespan, including variety of sensory modalities, sensory domains, and clinical correlates.
- Trial name
- NCT05829161
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cancer, Mental Health
Healthspan Connect Programme of Research
Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and…
- Conditions
- Cancer, Mental Health, Ageing Well, Resilience
- Trial name
- NCT07209774
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiometabolic Health Indicators, Child Health
Non-Invasive Assessment of Early Health Determinants in Children and Adolescents
LONGEVITY-NEXT is a single-center, non-profit observational study designed to assess early non-invasive determinants of cardiometabolic, functional, behavioral, and environmental health in children and adolescents aged 6 to 17…
- Trial name
- LONGEVITY-NEXT (NCT07861516)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dental Caries, Secondary Dental Caries
Influence of the Number of Layers of a One Bottle Adhesive on the Longevity of Composite Restorations in Primary Molars
The aim of this study is to determinate the influence of an alternative adhesive application protocol (i.e. consecutive application of an extra adhesive layer)on restoration longevity in primary molars.
- Trial name
- NCT01680289
- Testing
- Three adhesive coats, Two adhesive coats
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Dental Restorations Longevity, Dental Restoration Failure
Impact of Patients Risk Factors on the Longevity of Aesthetic Restorations
The objective of this double-blind randomized clinical trial is to evaluate the influence of caries risk, occlusal stress and missing teeth on anterior restorations over a 10 years follow up period.
- Conditions
- Dental Restorations Longevity, Dental Restoration Failure, Esthetics, Dental
- Trial name
- NCT03834636
- Testing
- Restorations with nanoparticulated composites and self etch adhesives, Restorations with nanoparticulated composites and total-etch adhesives, Restorations with nanohybrid composites and self etch adhesives
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Hypomineralization Molar Incisor, Hypersensitivity Dentin
Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity
Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT06538142
- Testing
- Photobiomodulation + Restoration with Self-cure Composite Resin, Restoration with Self-cure Composite Resin, Photobiomodulation + Restoration with Photopolymerizable Bulk-fill Composite Resin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Healthy Aging
Vitamin D3 - Omega3 - Home Exercise - HeALTHy Aging and Longevity Cohort
The DO-HEALTH trial will be extended into the cohort including the collection on life style factors such as diet, quality of life and physical activity, as well as health-related data on co-morbid conditions as well as a…
- Trial name
- DO-HEALTH-C (NCT05062018)
- Where
- Switzerland
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Heike Bischoff-Ferrari
Sarcoma
Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
This study evaluates the impact that a sarcoma diagnosis and treatment have had on patients over time.
- Trial name
- CAUSAL (NCT06482957)
- Testing
- Surveys, Blood Collection, Saliva Collection
- Where
- United States
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Obsessive-Compulsive Disorder
Neurocircuit Mechanisms of OCD Across the Lifespan
Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability…
- Trial name
- NCT02437773
- Testing
- Cognitive Behavioral Therapy - Adolescents, Stress Management Therapy - Adolescents, Optional CBT - Adolescents
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vaccine Reaction
Antibody Response and Longevity Post SARS-CoV-2 Vaccine (SARS-AB)
Longitudinal study on healthy subjects to investigate the longevity of the antibody response to the Pfizer-BioNTech COVID-19 vaccine.
- Trial name
- SARS-AB (NCT05515081)
- Testing
- blood sample collection
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Healthy Volunteers
Quality of Life and Behavioral Change of Retired Persons
Researchers have found that the first phase of aging, called "frailty", is insidious, silent and slowly progressive. It begins well before the first signs of aging and possibly before retirement age with physiological reserves…
- Trial name
- R-FORM' (NCT06432010)
- Testing
- Group nutrition and physical activity coaching, Group cognition coaching
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Children, Adult
Standing Balance Control Across the Lifespan
Falls are the leading cause of nonfatal injuries in children and elderly. To understand the causes of falling in these populations, fundamental knowledge of how ageing affects balance control is of utmost importance.
- Trial name
- BaCoMech (NCT04050774)
- Testing
- Balance boards
- Where
- Belgium
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hasselt University