Clinical trials: Longevity
Dental Restorations Longevity, Dental Restoration Failure
Impact of Patients Risk Factors on the Longevity of Aesthetic Restorations
The objective of this double-blind randomized clinical trial is to evaluate the influence of caries risk, occlusal stress and missing teeth on anterior restorations over a 10 years follow up period.
- Conditions
- Dental Restorations Longevity, Dental Restoration Failure, Esthetics, Dental
- Trial name
- NCT03834636
- Testing
- Restorations with nanoparticulated composites and self etch adhesives, Restorations with nanoparticulated composites and total-etch adhesives, Restorations with nanohybrid composites and self etch adhesives
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Cardiometabolic Health Indicators, Child Health
Non-Invasive Assessment of Early Health Determinants in Children and Adolescents
LONGEVITY-NEXT is a single-center, non-profit observational study designed to assess early non-invasive determinants of cardiometabolic, functional, behavioral, and environmental health in children and adolescents aged 6 to 17…
- Trial name
- LONGEVITY-NEXT (NCT07861516)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metabolic Disease, Cardiovascular Diseases
Zhejiang Nutrition and Health Study
This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups.
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Healthy Aging
- Trial name
- NuLife (NCT05930717)
- Where
- 2 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Sarcoma
Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
This study evaluates the impact that a sarcoma diagnosis and treatment have had on patients over time.
- Trial name
- CAUSAL (NCT06482957)
- Testing
- Surveys, Blood Collection, Saliva Collection
- Where
- United States
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Healthy Volunteers
Quality of Life and Behavioral Change of Retired Persons
Researchers have found that the first phase of aging, called "frailty", is insidious, silent and slowly progressive. It begins well before the first signs of aging and possibly before retirement age with physiological reserves…
- Trial name
- R-FORM' (NCT06432010)
- Testing
- Group nutrition and physical activity coaching, Group cognition coaching
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Premature Tooth Exfoliation
Longevity of Prefabricated Band and Loop Versus Conventional Band and Loop Space Maintainers
To assess the longevity of prefabricated versus conventional band and loop space maintainers in children with prematurely lost first primary molars. A Randomized Clinical Trial
- Trial name
- NCT06573463
- Testing
- Prefabricated band and loop, Conventional Band and loop
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Hyperlipidemias, Diabetes
Social Needs Screening and Chronic Diseases Study (WE CARE)
The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful…
- Conditions
- Hyperlipidemias, Diabetes, Depression, Pediatric Asthma
- Trial name
- NCT06903897
- Testing
- WE CARE SDOH System, Standard Pediatric Care
- Where
- 3 sites in United States
- Volunteers
- 68,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Healthy, Multiple Sclerosis
Normal Chinese Lifespan Brain Charts Initiative (NCLBCI)
Major brain diseases (including neuroimmune diseases, neurodegenerative diseases, and cerebrovascular diseases) are leading causes of death and disability in humans.
- Conditions
- Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases
- Trial name
- NCT06643858
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Implantable Cardioverter Defibrillators, CRT-D Cardiac Resynchronization Therapy Defibrillator
LONGEVITY Study. Evaluation of the Device and Battery Longevity of Boston Scientific Market-released ICD and CRT-D Devices
The study is to determine the rate and cause of device replacements at 5 years post-implantation. It will assess the battery and device longevity of the Implantable Cardioverter Defibrillators (ICD) and CRT-D Cardiac…
- Trial name
- NCT02091011
- Where
- 80 sites in United States, Canada and 6 more
- Volunteers
- 1,600 people
- Sponsor
- Boston Scientific Corporation
Dental Veneers, Resin Cements
Adhesive Cementation Materials and Techniques in Aesthetic Dentistry
AIM: To determine the most effective cementation method and resin cement material for long term success of esthetical restorations TASKS: 1.
- Conditions
- Dental Veneers, Resin Cements, Composite Restoration, Orofacial Esthetic Scale
- Trial name
- NCT07491809
- Testing
- Porcelain veneers, Direct composite
- Where
- Latvia
- Volunteers
- 60 people
- Sponsor
- Riga Stradins University
Congenital Heart Disease, Complex Congenital Heart Disease
A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease
The goal of this observational study is to learn about recovery after heart surgery for people with Complex Congenital Heart Disease (CCHD), build a comprehensive data platform for CCHD care across a person's whole life, and…
- Conditions
- Congenital Heart Disease, Complex Congenital Heart Disease, Surgery (Cardiac), Perioperative Care
- Trial name
- NCT07524998
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
HIV Infections, Aging
Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE)
The ARCHIVE study is an observational longitudinal cohort study of people with and without HIV who are over the age of 55. The duration of the study is planned for 10 years, with study visits every 1-2 years.
- Trial name
- ARCHIVE (NCT04641013)
- Where
- 11 sites in Australia
- Volunteers
- 446 people
- Sponsor
- Kirby Institute
Down Syndrome, Chromosome Disorders
Collaboration for Down Syndrome Progress (CDP)
The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time.
- Conditions
- Down Syndrome, Chromosome Disorders, Intellectual and Developmental Disabilities
- Trial name
- CDP (NCT07625579)
- Where
- 16 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- RTI International
Obsessive-Compulsive Disorder
Neurocircuit Mechanisms of OCD Across the Lifespan
Obsessive-compulsive disorder (OCD), characterized by intrusive thoughts (obsessions) and related behavioral rituals (compulsions), is a common psychiatric illness that often emerges in childhood and causes life-long disability…
- Trial name
- NCT02437773
- Testing
- Cognitive Behavioral Therapy - Adolescents, Stress Management Therapy - Adolescents, Optional CBT - Adolescents
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dental Caries, Dental Caries in Children
Restoration Repairs Using Composite Resin Versus Glass Ionomer in Primary Molars: a Randomized Clinical Trial
The objective of this randomized clinical study is to evaluate the survival of repairs in restorations using composite resin (CR) or high viscosity glass ionomer cement (GIC) in primary molars.
- Trial name
- NCT04491981
- Testing
- Encapsulated Glass Ionomer Cement, Composite resin
- Where
- Brazil
- Volunteers
- 312 people
- Sponsor
- University of Sao Paulo
Neonatal Peripheral Intravenous Cannulation, Limb Splinting
Limb Splinting for Intravenous Cannulae in Neonates and Its Effects on Life Span of Intravenous Cannulae
The goal of this randomized controlled trial is to assess the effectiveness of limb splinting in increasing the lifespan of intravenous (IV) cannulae in neonates.
- Conditions
- Neonatal Peripheral Intravenous Cannulation, Limb Splinting, Intravenous Cannula Lifespan, Extravasation
- Trial name
- NCT06615063
- Testing
- Hasi's Splint
- Where
- Pakistan
- Volunteers
- 246 people
- Sponsor
- Rawalpindi Medical College
Dental Restoration Failure
Operator Experience and Restorative Clinical Performance of Posterior Composite Restorations
This retrospective observational study aimed to evaluate the long-term clinical performance of posterior resin composite restorations placed by undergraduate dental students and postgraduate specialty trainees in pediatric…
- Trial name
- NCT07375706
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bezmialem Vakif University
Symptoms of Post Traumatic Stress Disorder (PTSD)
Lifespan Integration After Sexual Trauma
A new psychological trauma treatment method is tested on a population (n 100) of adult women who have been sexually traumatized at one specific time 0-5 years before they enter the study.
- Trial name
- NCT03141047
- Testing
- Lifespan Integration
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Insamlingsstiftelsen Wonsa, World of No Sexual Abuse
Healthy Aging
Vitamin D3 - Omega3 - Home Exercise - HeALTHy Aging and Longevity Cohort
The DO-HEALTH trial will be extended into the cohort including the collection on life style factors such as diet, quality of life and physical activity, as well as health-related data on co-morbid conditions as well as a…
- Trial name
- DO-HEALTH-C (NCT05062018)
- Where
- Switzerland
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Heike Bischoff-Ferrari