Clinical trials: Low Cardiovascular Risk
Diabetes
Meta-analysis of Low GI/GL Diets and Cardiometabolic Risk in Diabetes
Low glycemic index and low glycemic load diets have been shown to improve glycemic control and cardiometabolic risk factors in randomized controlled trials in people with diabetes and are associated with reduced incidence of…
- Trial name
- NCT04045938
- Testing
- Low Glycemic Index or Glycemic Load
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Aortic Stenosis
Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement
100 subjects in the each of the treatment arms of the study (total 200 treatment arm subjects) and up to 100 subjects in the registry arm of the study.
- Trial name
- NCT03557242
- Testing
- TAVR, Warfarin plus Aspirin, Aspirin Only
- Where
- 7 sites in United States
- Volunteers
- 124 people
- Sponsor
- Medstar Health Research Institute
Blood Coagulation, Disorders, Surgical Procedures, Minimally Invasive
Is Plasma Transfusion Beneficial Prior to Low-Risk Procedures in Hospitalized Patients With Blood Clotting Abnormalities?
Blood clotting abnormalities or problems that happen during surgery ? even minor surgery ? are serious because of the possibility of serious bleeding that cannot be stopped.
- Trial name
- NCT00953901
- Testing
- Fresh Frozen Plasma Transfusion
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Preeclampsia Severe, Cardiovascular Diseases
Postpartum Low-Dose Aspirin After Preeclampsia for Optimization of Cardiovascular Risk (PAPVASC)
Women who develop preeclampsia (PE) in pregnancy are at a greater risk for adverse cardiovascular health outcomes. PE is associated with vascular remodeling and functional changes in the postpartum, reflective of its systemic…
- Conditions
- Preeclampsia Severe, Cardiovascular Diseases, Primary Prevention
- Trial name
- PAPVASC (NCT04243278)
- Testing
- Low-dose aspirin
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Dr. Graeme Smith
Rare Diseases, Marfan Syndrome
Analysis of Muscular Properties in Patients With MFS and EDS
The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS).
- Conditions
- Rare Diseases, Marfan Syndrome, Ehlers-Danlos Syndrome
- Trial name
- MUSCLE (NCT05720923)
- Testing
- Analysis with Ergometer
- Where
- Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Cardiovascular Disease, Hypercholesterolemia
Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol
The purpose of this study is to investigate the short-term effects of a reduced fat plant-based diet on biomarkers of inflammation, oxidative stress and cardiovascular risk.
- Conditions
- Cardiovascular Disease, Hypercholesterolemia, Obesity, Fatty Liver
- Trial name
- NCT01817491
- Testing
- American Heart Association Diet, Reduced Fat Vegan Diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Hemodynamics Instability, Arrhythmias Cardiac
Low and Moderete Flow Anaesthesia on Haemodynamics
The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.
- Conditions
- Hemodynamics Instability, Arrhythmias Cardiac, Cerebral Oxygenation
- Trial name
- NCT06871371
- Testing
- Sevoflurane (Volatile Anesthetic), low- medium flow anesthetic machine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Umraniye Education and Research Hospital
Fontan Procedure
Clinical Outcomes in Fenestrated Extra-Cardiac Fontan in Low Preoperative Risk Profiles
Evaluation of fenestration benefit in Extra-cardiac total cavo-pulmonary connection (Fontan procedure) in single ventricle anomaly, comparing clinical outcomes of patients with low preoperative risk profiles in prospective study
- Trial name
- NCT03503032
- Testing
- Extracardiac Fontan, Fontan fenestration
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Hypertension, Pregnancy-Induced, Hypertension, Essential Hypertension
Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy
Background: 1. Burden: Hypertensive disorders of pregnancy, including preeclampsia, complicate up to 10% of pregnancies worldwide, constituting one of the greatest causes of fetal growth restriction, preterm birth, low birth…
- Conditions
- Hypertension, Pregnancy-Induced, Hypertension, Essential Hypertension, Hypertension; Pre-Eclampsia, Hypertension in Pregnancy
- Trial name
- NCT03858595
- Testing
- Self monitoring of blood pressure using Health Gauge Device and monthly monitoring of weight gain
- Where
- Bangladesh
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pulmonary Embolism, Lung Diseases
Identifying Low-Risk Patients With Pulmonary Embolism
To develop a clinical prediction rule to identify patients with acute pulmonary embolism who are at very low risk for short-term adverse outcomes.
- Trial name
- NCT00086151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction
Safety And Feasibility of Early DischargE - a Prospective And Randomized Trial of Low-risk Primary Percutaneous Coronary Intervention (PCI) Patients
The purpose of this study is to determine if early hospital discharge (at 48-72 hours), is feasible, safe, cost-effective, and/or improves compliance with medications, positive lifestyle changes and quality-of-life, in low-risk…
- Trial name
- SAFE-DEPART (NCT00474214)
- Testing
- Early hospital discharge facilitated by close nurse practitioner follow-up
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Hamilton Health Sciences Corporation
Cardiovascular Diseases, Heart Diseases
Evaluation of Low Literacy CVD Nutrition Education
To develop and evaluate a nutrition education program to reduce cardiovascular disease risk in persons with low literacy skills.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Heart Disease Risk Reduction
- Trial name
- NCT00005726
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Vesicle
Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration
Extracellular vesicles (EVs) are small vesicles deriving from all cell types during cell activation, involved in transcellular communication, and regarded as predictors of vascular damage and of cardiovascular events.
- Trial name
- NCT05584943
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Aortic Valve Stenosis
Sentinel Low Risk Registry
This registry is designed to quantify embolic debris capture rate in patients at low surgical risk treated with the Sentinel System during TAVI.
- Trial name
- NCT04131127
- Testing
- Sentinel Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- CVPath Institute Inc.
Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Acute Undifferentiated Leukemia
Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies
This clinical trial studies fludarabine phosphate and total-body radiation followed by donor peripheral blood stem cell transplant and immunosuppression in treating patients with hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00014235
- Testing
- fludarabine phosphate, total-body irradiation, peripheral blood stem cell transplantation
- Where
- 11 sites in United States, Germany and 1 more
- Volunteers
- 160 people
- Sponsor
- Fred Hutchinson Cancer Center
Aortic Stenosis
Isolated Surgical Aortic Valve Replacement in Low Risk AS Patients
To establish the safety and effectiveness of surgical aortic valve replacement (SAVR) in patients with isolated severe, calcific aortic stenosis who are at low surgical risk.
- Trial name
- AMETHYST (NCT06924151)
- Testing
- surgical aortic valve replacement, Transcatheter aortic valve replacement
- Where
- 37 sites in Japan
- Volunteers
- 450 people
- Sponsor
- Osaka University
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Body Weight, Obesity
Meta Analysis of the Effect of a Low Glycemic Index Diet and Glycemic Load on Body Weight
A low glycemic index (GI) diet has been associated with improved glycemic control in type 2 diabetes patients and a reduced risk of cardiovascular disease (CVD).
- Conditions
- Body Weight, Obesity, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT02557022
- Testing
- GI and/or GL
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Aortic Stenosis
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement.
- Trial name
- P3 (NCT02675114)
- Testing
- SAVR, SAPIEN 3 THV
- Where
- 77 sites in United States, Australia and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Edwards Lifesciences