Clinical trials: Lower Limb Injury
Anterior Cruciate Ligament Injuries
Clinical Application of the Apex of the Deep Cartilage in Evaluating the Femoral Tunnel of the ACL Reconstruction
With the apex of the deep cartilage (ADC) as the symbol, the consistency of the two methods in the postoperatively computed tomography (CT) and microscopic evaluation of the position of the femoral tract of the anterior cruciate…
- Trial name
- NCT04953546
- Testing
- No Intervention
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Tibial Fracture
SPRINT - Randomized Trial of Tibial Fracture Fixation
The purpose of this study is to determine if there is a difference in the rate of healing of a tibia fracture treated with an intramedullary nail based on whether or not the bone was reamed prior to nail insertion.
- Trial name
- NCT00038129
- Testing
- Intramedullary nail implant
- Where
- 16 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Minnesota
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Anterior Cruciate Ligament Injuries
Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
To evaluate the effect of graded exposure and mindfulness meditation after ACLR, the investigators will determine the effect of graded exposure and mindfulness meditation to 1) decrease self-reported injury-related fear and…
- Trial name
- NCT05949177
- Testing
- Graded Exposure and Mindfulness Meditation, Waitlist Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Dislocated Patella, Torn Medial Patellofemoral Ligament
Repair of Medial Patellofemoral Ligament Compared to Conservative Treatment for First Time Patella Dislocation
Background: The forces involved in a patella dislocation event can cause significant collateral damage involving the articular cartilage of the patella femoral joint.
- Trial name
- NCT02185001
- Testing
- Direct Medial Patellofemoral Ligament (MPFL) Repair, Physical therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Orthopedic Specialty Institute
Ankle Fractures
Preliminary Review of Cold and Active Compression Therapy for Traumatic Calcaneus or Ankle Fractures
This study will examine the initial efficacy and cost-effectiveness of using the cryocompression therapy model both pre-operatively and post-operatively in patients that have recently suffered a traumatic calcaneus or ankle…
- Trial name
- NCT02498717
- Testing
- GameReady, RICE
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- AdventHealth
Anterior Cruciate Ligament Injuries
Steps Towards Osteoarthritis Prevention
Optimal knee joint loading, which refers to the forces acting on the knee caused by daily activities such as daily steps, plays an essential role in maintaining knee articular cartilage health and reducing the risk of…
- Trial name
- STOP (NCT06193343)
- Testing
- Adaptive Daily Step Promotion
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Georgia
Osteoporosis
GRACE - Study of AGN1 LOEP in Osteopenic and Osteoporotic Patients
The study is designed as a retrospective, single-center study for subjects previously treated with the AGN1 LOEP Kit. This will be a non-randomized and non-blinded study.
- Trial name
- NCT05966974
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- AgNovos Healthcare, LLC
Pelvic Fracture, Morel-Lavallee Lesion
A Retrospective Cohort Study of 15 Cases of Pelvic Fractures Complicated by Morel-Lavallee Lesion
Some related factors of pelvic fracture and Morel-Lavallee injury (MLL) are preliminarily discussed, which provides some preliminary references for early clinical detection and research of such injuries.
- Trial name
- NCT06388915
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Weikang Chen
Femoral Neck Fracture
Postoperative Analgesia With Local Infiltration After Femoral Neck Fracture
Reducing pain is an essential factor for early mobilization after osteosynthesis of femoral neck fractures. Systemic opioids have side effects that might obstruct mobilization and induce delirium and nausea.
- Trial name
- NCT00529425
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital
Rupture of Anterior Cruciate Ligament
The Effect of Early WBVT on Neuromuscular Control After ACLR
To investigate the effect of early WBVT on neuromuscular control after ACLR.
- Trial name
- WBVT (NCT01300182)
- Testing
- Whole body vibration therapy, Control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injuries
Individualized Anterior Cruciate Ligament Versus Conventional Reconstruction
A randomised prospective control trial comparing the efficiency of a more individualized approach in ACL reconstruction with the help of neuromuscular computer models with traditional ACL reconstruction practices.
- Trial name
- IACLR (NCT04366362)
- Testing
- Individualised ACL reconstruction, Conventional ACL reconstruction
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
ACL Injury, Quadriceps Muscle Atrophy
BFR Therapy After ACL Reconstruction
This study is a prospective, double-blinded, randomized control trial examining the effect of blood flow restriction (BFR) therapy on reducing post-operative quadriceps atrophy in patients undergoing anterior cruciate ligament…
- Trial name
- BFR (NCT03794570)
- Testing
- Blood flow restriction therapy - with Delfi Personalized Tourniquet System
- Where
- United States
- Sponsor
- Steadman Philippon Research Institute
Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair vs ACL Reconstruction
The goal of this trial is to compare the efficacy of the Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR™) technique with the current method of treatment for anterior cruciate ligament (ACL) injuries, ACL reconstruction.
- Trial name
- NCT02664545
- Testing
- BEAR Scaffold, Tendon Graft
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Miach Orthopaedics
Anterior Cruciate Ligament Injury
Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach
ACL injuries are common among athletes and due to residual muscle weakness, limited knee motion and asymmetrical movement patterns after surgery many of these athletes will sustain secondary ACL injuries following return to…
- Trial name
- NCT03273673
- Testing
- Biofeedback Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Polytechnic Institute and State University
Anterior Cruciate Ligament Injury
Functional Resistance Training to Improve Knee Function After ACL Reconstruction
The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury and reconstruction can be improved with functional resistance training.
- Trial name
- NCT03282565
- Testing
- Functional Resistance Training with Brace, Control, Functional Resistance Training with Elastic Band
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Femoral Neck Fracture
Interest of the OSA (Obstructive Sleep Apnea) Predictive Scores in the Prognosis of Postoperative Mortality of Femoral Neck Fractures
Interest of the four major OSA Predictive Scores (STOP-BANG, P-SAP, DES-OSA, OSA50) in the prognosis of postoperative mortality after femoral neck fracture.
- Trial name
- NCT02202122
- Testing
- OSA Scoring
- Where
- Belgium
- Sponsor
- Astes
Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligament Rupture
This clinical trial compared the prognosis of surgical and non-surgical treatment in patients with complete anterior cruciate ligament rupture
- Trial name
- NCT05403905
- Testing
- non surgical treatment, surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
ACL, ACL Injury
Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction
The goal of this study is to determine short-term adaptations (aftereffects) in knee loading after a 20-minute split-belt treadmill training session in patients with ACL reconstruction. Our main question for this aim are: 1.
- Trial name
- Mi-SPA (NCT06529679)
- Testing
- Split-belt Training, Tied-Belt Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan