Clinical trials: Lower Resp Tract Infection
Rhinovirus
The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study
The goal of this study is to determine the burden of Rhinoviruses (RVs) as a cause of acute, severe, respiratory illnesses leading to hospitalization.
- Trial name
- NCT07342582
- Testing
- Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Respiratory Tract Infections
Prevention of Respiratory Infections Among Children Under 3 Years of Age Attending Daycare Centres
The aim of this study is to evaluate the influence of Primary and Secondary Prevention of Respiratory Infections in children up to 3 years-old attending daycare.
- Trial name
- PRICAD (NCT02588963)
- Testing
- Health education session, Nasal clearance Protocol, Control
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Polytechnic Institute of Porto
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Severe Respiratory Disease
Study to Evaluate the Human Infection of the Lower Respiratory Tract in Children at High Risk
Estimate the incidence rate of hMPV infection detected by RT-PCR from frozen nasal wash aspirates in children at high risk for severe LRI disease (hospitalized at <2 years of age).
- Trial name
- NCT00192439
- Testing
- High Risk Respiratory Disease
- Where
- 24 sites in United States, Australia and 2 more
- Volunteers
- 1,500 people
- Sponsor
- MedImmune LLC
Respiratory Syncytial Virus Infections
A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV
The purpose of the study is to learn about the safety and amount of sisunatovir in the blood of infants and children up to age 60 months.
- Trial name
- NCT06102174
- Testing
- Active
- Where
- 9 sites in United States, Japan and 1 more
- Volunteers
- 10 people
- Sponsor
- Pfizer
Lower Respiratory Tract Infection
Recovery Time in Children With Lower Respiratory Tract Infections Treated With Klacid® Granules for Oral Suspension.
Klacid Granules for Oral Suspension provides short symptoms' recovery time in Thai children with lower respiratory tract infections.
- Trial name
- NCT01076166
- Testing
- clarithromycin (Klacid) granules for oral suspension
- Where
- 16 sites in Thailand
- Volunteers
- 337 people
- Sponsor
- Abbott
Acute Lower Respiratory Illness
Cookstove Replacement for Prevention of ALRI and Low Birthweight in Nepal
At our field site in southern Nepal, acute respiratory illness (ARI) has been a leading cause of mortality among young children.
- Trial name
- NCT00786877
- Testing
- Improved biomass cookstove with exterior ventilation, Phase 2 intervention arm (LPG stove)
- Where
- Nepal
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Community-Acquired Pneumonia, Pediatric Pneumonia
Clinical Predictors of Severity in Pediatric Community-Acquired Pneumonia at Assiut University Children's Hospital
This study aims to identify the clinical factors that predict the severity of community-acquired pneumonia (CAP) in pediatric patients.
- Conditions
- Community-Acquired Pneumonia, Pediatric Pneumonia, Lower Respiratory Tract Infection
- Trial name
- CAP-Severity (NCT07279675)
- Testing
- Assessment of Pneumonia Severity
- Volunteers
- 67 people
- Sponsor
- Assiut University
Respiratory Viral Infections, Respiratory Syncytial Virus Infections
Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age
The overall objective of the MEDI-534 clinical development program is to evaluate the safety, efficacy and tolerability of MEDI-534 for the prevention of serious RSV and PIV3 disease in young infants.
- Conditions
- Respiratory Viral Infections, Respiratory Syncytial Virus Infections, Parainfluenza Virus 3, Human
- Trial name
- CP149 (NCT00493285)
- Testing
- MEDI-534
- Where
- 30 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Pneumnia, Chest Infection
Use of Simplified Lung Ultrasound Score for Predicting ICU Outcomes in Patients With Acute Respiratory Failure
This study aims to Primary Aims: Verify the predictability of the PLIS at admission in predicting major clinical outcomes including: ICU mortality (or discharge) and time to death (or discharge) Escalation of ventilatory support…
- Conditions
- Pneumnia, Chest Infection, Critically-ill Patients Admitted to the ICU for Acute Respitatory Failure, Regardless the Aetilogy
- Trial name
- NCT06678035
- Volunteers
- 72 people
- Sponsor
- Assiut University
RSV Infections, RSV Immunisation
A Clinical Trial on Safety in Pregnant Women and How Well the Infant is Protected Against RSV-associated Lower Respiratory Tract Infection When the Pregnant Woman Receives the Approved RSV Vaccine Compared to a Placebo.
Respiratory syncytial virus (RSV) is a virus that often affects children during childhood. Even though most cases of RSV are mild, it can cause serious disease and even death - especially in very young babies, babies born too…
- Conditions
- RSV Infections, RSV Immunisation, Preterm Labour
- Trial name
- NCT06955728
- Testing
- Vaccine
- Where
- 11 sites in Ghana, Kenya and 2 more
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Children Chest Infection
Bacterial Pathogens Associated With Community-acquired Pneumonia in Children
Pediatric community acquired pneumonia (CAP) is one of the most common reasons for hospital admission, there is no reliable way of distinguishing the causative organism based on clinical features.
- Trial name
- NCT06377163
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Delta University for Science and Technology
Acute Respiratory Tract Infection
Differentiation of Upper and Lower Respiratory Tract Infections Using Automated Lung Sound Analysis With LungPass Device
This observational study evaluates whether lung sound analysis with LungPass device can be used to differentiate upper and lower respiratory tract infections (URTI and LRTI)
- Trial name
- NCT05175612
- Testing
- Lung auscultation with LungPass device (electronic auscultation)
- Where
- Belarus
- Volunteers
- 400 people
- Sponsor
- Healthy Networks
Parainfluenza
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Examine the Effects of DAS181 in Immunocompromised Subjects With Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen
This protocol will seek to enroll immunocompromised patients who are on supplemental oxygen and diagnosed with a parainfluenza infection.
- Trial name
- DAS181-2-05 (NCT01644877)
- Testing
- DAS181 dry powder, formulation F02
- Where
- 45 sites in United States
- Volunteers
- 111 people
- Sponsor
- Ansun Biopharma, Inc.
Croup, Bronchiolitis
A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department
Aim of study is to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of paediatric respiratory disease in the study's clinical setting compared to a Clinical Adjudication Committee's (CAC) diagnosis; and…
- Conditions
- Croup, Bronchiolitis, Asthma in Children, Reactive Airway Disease
- Trial name
- NCT06156436
- Testing
- ResAppDx v.20
- Where
- 5 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- ResApp Health Limited
Respiratory Tract Infections, Upper Respiratory Tract Infections
Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England
The purpose of this study is to investigate whether there has been a change in the number of hospital admissions for respiratory tract infections among children following the July 2007 introduction of a ban on smoking in public…
- Conditions
- Respiratory Tract Infections, Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
- Trial name
- NCT01920165
- Testing
- Smoke-free legislation
- Where
- United Kingdom
- Volunteers
- 1,660,652 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Respiratory Infection (for Example, Pneumonia, Bronchitis)
Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic
This project aims to study the benefits of probiotics namely Bifidobacterium lactis M8 in treatment of upper and lower respiratory tract infections in young children, which are found common among children in Malaysia aged from…
- Trial name
- NCT04122495
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Gastrointestinal Tract Infections, Respiratory Tract Infections
Bifidobacterium Animalis Subsp. Lactis for Lowering the Risk of Common Infections in Hospitalized Children
Hypothesis: Use of Bifidobacterium animalis subsp. lactis can effectively prevent common nosocomial (gastrointestinal and respiratory) infections.
- Trial name
- PROBIC II (NCT01702766)
- Testing
- Bifidobacterium animalis subsp. lactis
- Where
- Croatia
- Sponsor
- Children's Hospital Zagreb
Bronchiolitis, Acute Bronchiolitis
Risk Factors and Severity of Bronchiolitis in Hospitalized Children at Assiut University Hospital
The purpose of this observational study is to identify the risk factors that make bronchiolitis more severe in infants and toddlers.
- Conditions
- Bronchiolitis, Acute Bronchiolitis, Respiratory Syncytial Virus Infection
- Trial name
- NCT07505420
- Volunteers
- 65 people
- Sponsor
- Assiut University
Healthy
Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children
This is a randomized, double-blind, placebo-controlled, dose-escalation, Phase 1, multi-center study to evaluate the safety, tolerability, immunogenicity, and viral shedding of MEDI-534 in healthy children 1-9 years of age who…
- Trial name
- NCT00345670
- Testing
- MEDI-534
- Where
- 12 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC