Clinical trials: Lower Respiratory Infection
Upper Respiratory Tract Infections, Urinary Tract Infections
Routine Prescription Feedback and Peer Comparison to Lower Antibiotic Prescriptions in Primary Care
To evaluate the effect of a continuous postal and web-based feedback and peer comparison system of individual antibiotic prescription rates on the prescription behaviour of primary care physicians in Switzerland.
- Trial name
- NCT01773824
- Testing
- Antibiotic prescription feedback, No Feedback
- Where
- Switzerland
- Volunteers
- 2,900 people
- Sponsor
- University Hospital, Basel, Switzerland
Pneumonia, Diarrhea
Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia.
- Conditions
- Pneumonia, Diarrhea, Acute Upper Respiratory Tract Infections
- Trial name
- NCT00228254
- Testing
- Zinc (12.5 mg/day), vitamin A 10,000 IU per week
- Where
- 2 sites in United States, Ecuador
- Volunteers
- 2,582 people, healthy volunteers welcome
- Sponsor
- Tufts University
Respiratory Tract Infections (RTI), Lower Respiratory Tract Infection (LRTI)
Respiratory Infections in Young Children
The goal of this observational study is to learn about the causes, severity, and long-term effects of respiratory tract infections (RTIs) in young children from birth to five years of age in Colombia and Panamá.
- Conditions
- Respiratory Tract Infections (RTI), Lower Respiratory Tract Infection (LRTI), Viral Infections, Cohort Study
- Trial name
- MINERVAL (NCT07249996)
- Where
- 2 sites in Colombia, Panama
- Volunteers
- 1,088 people, healthy volunteers welcome
- Sponsor
- Eduardo Lopez -Medina
Infection
Unnecessary IV Antibiotic Days Using General Criteria for Antibiotic Switch
Observation of the use of intravenous antibiotics in medical clinic of Sorlandet Hospital, Norway. Suggestions of criteria for the switch from intravenous to oral administration of antibiotics.
- Trial name
- NCT00763373
- Testing
- Implementation of antibiotic switch guidelines
- Where
- 2 sites in Norway
- Volunteers
- 187 people
- Sponsor
- Sorlandet Hospital HF
Biofire Filmarray
Diagnosis of Lower Respiratory Tract Infections Using Biofire Filmarray
Comparison of pathogens causing lower respiratory tract infections in ventilated versus non ventilated pediatric patients in intensive care unit using biofire filmarray and vitek2 Antibiotic sensitivity using vitek2 Comparison of…
- Trial name
- NCT04283422
- Testing
- Biofire filmarray
- Volunteers
- 60 people
- Sponsor
- Assiut University
Respiratory Disease
The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections
Congenital heart disease can lead to serious health issues, particularly an increased risk of infections, specifically respiratory infections. Lower respiratory tract infections are the fifth leading cause of death globally.
- Trial name
- NCT06926712
- Testing
- Vitamin E
- Volunteers
- 260 people
- Sponsor
- Assiut University
Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
Prevention of Respiratory Infections and MAnagement Among Children (PRIMAKid)
The PRIMAKid trial is a general practice based double-blind randomized placebo-controlled trial on the effectiveness and costs of combined influenza and pneumococcal vaccination in pre-school children with recurrent respiratory…
- Trial name
- NCT00161122
- Testing
- trivalent inactivated influenza vaccine, combined heptavalent pneumococcal conjugate vaccine and trivalent inactivated influenza vaccine
- Where
- Netherlands
- Volunteers
- 660 people
- Sponsor
- UMC Utrecht
Respiratory Syncytial Virus
A Study in Belgian Children Hospitalized With Respiratory Syncytial Virus Related Acute Respiratory Infections
The purpose of the study is to assess viral kinetics and clinical symptoms kinetics in pediatric patients hospitalized with Respiratory Syncytial Virus (RSV) confirmed lower respiratory tract infection (LRTI).
- Trial name
- NCT02133092
- Testing
- No intervention
- Where
- 4 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Janssen Research & Development, LLC
Community-acquired Acute Lower Respiratory Infection
Advanced Diagnostics for Enhanced QUality of Antibiotic Prescription in Respiratory Tract Infections in Emergency Rooms
This study is a randomized controlled trial where participants are randomly assigned in a 1:1 ratio to either a rapid test group or a control group. Standard care is provided in the control group.
- Trial name
- ADEQUATE (NCT04781530)
- Testing
- BioFire FilmArray Respiratory Panel 2.1 plus (RP2.1plus)
- Where
- 6 sites in Germany, Greece and 3 more
- Volunteers
- 522 people
- Sponsor
- PENTA Foundation
Severe Illness, Septicaemia
Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda
BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis.
- Conditions
- Severe Illness, Septicaemia, Diarrhoea, Lower Respiratory Infection
- Trial name
- NCT02606526
- Testing
- BCG at birth, Control arm: Delayed BCG
- Where
- Uganda
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Makerere University
Lower Respiratory Tract Infection
Evaluate the Safety and Efficacy of Nirsevimab in Healthy Preterm and Term Infants in China
The purpose of this study is to evaluate the Safety and Efficacy of Nirsevimab, in Healthy Preterm and Term Infants in China
- Trial name
- CHIMES (NCT05110261)
- Testing
- Nirsevimab
- Where
- 30 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Bronchiolitis, Lower Respiratory Tract Infection
Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial
The goal of this clinical trial is to find out at which lower limit for saturation (amount of oxygen in the blood) we can best give extra oxygen to children that have been admitted for shortness of breath.
- Conditions
- Bronchiolitis, Lower Respiratory Tract Infection, Bronchial Hyperreactivity
- Trial name
- OxyKids (NCT06016244)
- Testing
- Oxygen saturation threshold
- Where
- 9 sites in Netherlands
- Volunteers
- 566 people
- Sponsor
- Spaarne Gasthuis
Bronchiolitis, Bronchiolitis Acute Viral
Analysis of Variability in the Management of Respiratory Infections in Hospitalized Patients Under 2 Years of Age
Medical practice variability refers to differences in treatment and clinical outcomes that cannot be solely explained by patient characteristics or medical conditions.
- Trial name
- NCT07202585
- Where
- Argentina
- Volunteers
- 127 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
COVID-19 Pandemic, COVID-19 Respiratory Infection
Residual Symptoms and the Quality of Life in Individuals Recovered From COVID-19 Infection: A Survey From Pakistan
There remains scarcity of literature regarding the patient's health status post-COVID-19 infection. This study analyzes the prevalence of residual symptoms and quality of life (QoL) after COVID-19.
- Conditions
- COVID-19 Pandemic, COVID-19 Respiratory Infection, COVID-19 Lower Respiratory Infection
- Trial name
- NCT05148676
- Testing
- Residual Symptoms and the Quality of Life in Individuals Recovered from COVID-19 Infection: A Survey from Pakistan
- Where
- Pakistan
- Volunteers
- 331 people
- Sponsor
- Aga Khan University
Pneumonia, Bronchiolitis
Diagnosing Respiratory Disease in Children Using Cough Sounds
The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in diagnosis of pneumonia and other respiratory conditions (bronchiolitis, asthma/reactive airway disease, croup, upper or…
- Conditions
- Pneumonia, Bronchiolitis, Asthma, Croup
- Trial name
- SMARTCOUGH-C (NCT02973282)
- Testing
- Recording of Infants and Children's Cough Sounds
- Where
- 3 sites in United States
- Volunteers
- 1,245 people
- Sponsor
- ResApp Health Limited