Clinical trials: MCI
Amnestic Mild Cognitive Impairment
Outcome Predictors of a Cognitive Intervention in aMCI
Cognitive training has been shown to be successful in patients with amnestic mild cognitive impairment (aMCI), a group at high-risk for Alzheimer's disease (AD).
- Trial name
- OutPreC MCI (NCT01525368)
- Testing
- cognitive intervention
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Mild Cognitive Impairment, Alzheimers Disease
Multiple Nutritional Deficiencies Causing Dementia of the Alzheimer Type
The purpose of the study is to compare the concentrations of Vitamin B1 (thiamine), Vitamin B6 (pyridoxal-5-phosphate), folate, Vitamin B12 (cobalamin), Vitamin C (ascorbic acid), Vitamin A (retinol), Vitamin E (alfa-tocopherol)…
- Trial name
- ALZ-vit (NCT01479855)
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Alzheimer Disease, MCI
Detecting Dementia Earlier
Aims 1. To determine whether the 4 Mountains test of allocentric (i.e. viewpoint-independent) spatial memory, and tests of memory for a recent experience (e.g.
- Conditions
- Alzheimer Disease, MCI, Aging
- Trial name
- DDE (NCT03900936)
- Testing
- Neuropsychological tests
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Mild Cognitive Impairment, Neurocardiogenic Syncope
VINCI-AD: An Investigation of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment.
The VINCI-AD study will investigate the impact of non-invasive vagus nerve stimulation (VNS) on memory in participants with existing mild memory impairment. VNS is a safe, existing treatment, licensed in epilepsy and depression.
- Conditions
- Mild Cognitive Impairment, Neurocardiogenic Syncope, Memory Impairment, Inflammatory Response
- Trial name
- NCT05514756
- Testing
- Active t-VNS, Baseline assessments
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Tallaght University Hospital
Alzheimers' Disease
Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia
A total of 200 home dwelling participants, who fulfil the inclusion criteria, Alzheimer's disease, will be recruited from three hospitals in Norway.
- Trial name
- NCT02013518
- Testing
- Cognitive Behavioural Therapy
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety…
- Trial name
- NCT04771845
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 73 people
- Sponsor
- The New York Memory Services
Parkinson Disease, Mild Cognitive Impairment
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Memory Impairment
- Trial name
- TRIP (NCT04643327)
- Testing
- Levetiracetam
- Where
- Australia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Parkinson Disease, Memory Disorders
GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment
This study examines the safety and feasibility of DBS in treating the movement and cognitive dysfunction in Parkinson's disease (PD).
- Trial name
- 2T-DBS (NCT04571112)
- Testing
- NBM stimulation using the Vercise device (Boston Scientific, Marlborough, Massachusetts, US)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Toronto
Parkinson Disease, COVID-19
Effect of Remote Cognitive Intervention in Patients With Parkinson's Disease During the COVID-19 Pandemic
Retrospective study to evaluate the effect of a remote cognitive-rehabilitative intervention during the Covid outbreak in subjects with Parkinson's disease.
- Conditions
- Parkinson Disease, COVID-19, Mild Cognitive Impairment
- Trial name
- TELEPARK (NCT05476302)
- Testing
- Cognitive digital treatment
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Distorted; Balance, Motor Deficit
Virtual Reality Based Balance Training in People With Mild Cognitive Impairment
The aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in people with mild cognitive impairment.
- Conditions
- Distorted; Balance, Motor Deficit, Cognitive Deficit
- Trial name
- NCT02214342
- Testing
- Balance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Mild Cognitive Impairment (MCI)
Evaluation of the Effect of Healthy Lifestyle Intervention for Patients With Mild Cognitive Impairment
This clinical study aims to evaluate the feasibility and preliminary effectiveness of a comprehensive lifestyle intervention program for patients with mild cognitive impairment.
- Trial name
- NCT06942780
- Testing
- Exercise intervention, Social intervention, Dietary intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Dementia, Neurocognitive Disorders
Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia
This study aims to evaluate the effectiveness and cost-effectiveness of CST-ES, the Spanish adaptation of Cognitive Stimulation Therapy (CST), to improve cognition and quality of life in people with mild to moderate dementia.
- Conditions
- Dementia, Neurocognitive Disorders, Mild Cognitive Impairment
- Trial name
- NCT06372002
- Testing
- Cognitive Stimulation Therapy (CST)
- Where
- 46 sites in Spain
- Volunteers
- 683 people
- Sponsor
- Instituto de Mayores y Servicios Sociales (IMSERSO)
Mild Cognitive Impairment
Evaluation of an Intervention for Living With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a significant risk factor for dementia. Persons with MCI experience cognitive changes, most typically affecting memory; that are greater than those experienced in "normal" aging.
- Trial name
- NCT02083237
- Testing
- Behavioural Intervention Program
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Baycrest
Mild Cognitive Impairment
Tailored Mediterranean Lifestyle Education in Patients With Mild Cognitive Impairment
Evidence suggests that a Mediterranean diet can have a beneficial effect on brain health. Mild cognitive impairment (MCI) describes problems with brain function such as difficulty with day-to-day memory and concentration.
- Trial name
- NCT03265522
- Testing
- "ThinkMed" resource at baseline, Standard Care Control, "ThinkMed" resource (staged)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen's University, Belfast
Mild Cognitive Impairment
Effects of Shuttle Balance Training on Balance , Gait and Postural Control in Children With Mild Cognitive Impairment
This study aims to investigate the impact of Shuttle Balance Training (SBT) on balance, gait, and postural control among children diagnosed with mild cognitive impairment (MCI).
- Trial name
- NCT06974890
- Testing
- Shuttle Balance Training, Baseline Treatment
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Memory Disorders, Alzheimer Disease
Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
The current study will examine the impact of frequent social interaction through communication technologies during COVID-19 pandemic in the cognitive status of socially-isolated older adults with and without cognitive impairment.
- Conditions
- Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04480112
- Testing
- Technology based social interactions, No research related technology based social interactions
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Boston University
Mild Cognitive Impairment
Protocol of Multi-domain Attention Training
This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .
- Trial name
- NCT03379519
- Testing
- Multi-domain Attention Training (MAT), Passive information activities (PIA)
- Volunteers
- 60 people
- Sponsor
- Ministry of Science and Technology, Taiwan
Alzheimer Disease
Plasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI)
In the ADDITION-MCI project, patients with a diagnosis of mild cognitive impairment probably caused by Alzheimer's disease will receive plasma exchange.
- Trial name
- ADDITION-MCI (NCT06234436)
- Testing
- Plasma exchenge
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Mild Cognitive Impairment
An Intergenerational, Cognitively Enriched Intervention for MCI Patients and Their Children.
In 2018, approximately 50 million people received a diagnosis of dementia, which is projected to triple by 2050. To mitigate the increase in dementia, it is crucial to prevent cognitive decline in at risk groups, such as older…
- Trial name
- MCI-project (NCT06221579)
- Testing
- No intervention, interviews with MCI patients as part of the development phase
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Ghent