Clinical trials: MS
C10.114.375.500
Impact of the Arrival on the French Market of New First Line Oral Treatments on the Delay Between MS Onset and First Disease Modifying Treatment (DMTs) Administration
The study design matches with a multicenter observational ambispective study. A first pilot study will be undertaken in Caen center and is expected to be extended to Rouen and Lille center.
- Trial name
- PREMISEP (NCT03308994)
- Testing
- Delay between MS onset and introduction of first line DMT, EDI
- Where
- 4 sites in France
- Volunteers
- 650 people
- Sponsor
- University Hospital, Caen
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Multiple Sclerosis (MS) - Relapsing-remitting
Effects of Sailing and Cooing in the Quality of Life of Multiple Sclerosis Individuals
In this study, we aim to evaluate the impact of head and neck cooling on symptoms and psychological states in individuals with Multiple Sclerosis (MS) during a 7-day Oceans of Hope Challenge sailing trip around the Greek islands…
- Trial name
- MS Sailing (NCT06915272)
- Testing
- Head and Neck Cooling Intervention
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- University of Thessaly
Multiple Sclerosis
Quantitative Magnetic Resonance Imaging (MRI) Sub-Study of MS PATHS
The primary objective is to assess the performance of a new magnetic resonance imaging (MRI) metrics software prototype when used in radiological practice in multiple sclerosis (MS).
- Trial name
- NCT04145284
- Where
- 2 sites in United States, Germany
- Volunteers
- 6 people
- Sponsor
- Biogen
Multiple Sclerosis (MS)
A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis
A randomized multiple baseline feasibility trial where participants will start taking metformin at one of 3 randomly determined points (3-months, 6-months or 9 months) during the 12-month trial.
- Trial name
- NCT04121468
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis (MS), Neurogenic Bladder Disorder
Essential Oils for Urinary Symptoms in Multiple Sclerosis Patients
The goal of this clinical trial is to learn if essential oil aromatherapy works to improve urinary symptoms in adults with multiple sclerosis. It will also learn about the safety of essential oil use in this population.
- Conditions
- Multiple Sclerosis (MS), Neurogenic Bladder Disorder, Urinary Incontinence (UI), Urinary Urgency
- Trial name
- AROMA-MS (NCT07599189)
- Testing
- Essential Oil Blend (Lavender, Rosemary), Neutral Carrier Oil (Apricot Kernel Oil)
- Where
- 2 sites in Algeria
- Volunteers
- 60 people
- Sponsor
- University of Oran 1
Multiple Sclerosis (MS)
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
- Trial name
- NEOS (NCT04926818)
- Testing
- Fingolimod, Ofatumumab, Siponimod
- Where
- 51 sites in United States, Argentina and 23 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Lymph Node Radiation Therapy in Patients With Stage I, Stage II, or Stage III Breast Cancer That Has Been Surgically Removed
RATIONALE: Radiation therapy may kill any tumor cells remaining after surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared to no further therapy in treating women with…
- Trial name
- NCT00002851
- Testing
- adjuvant therapy, low-LET electron therapy, low-LET photon therapy
- Where
- 48 sites in Belgium, Bosnia and Herzegovina and 12 more
- Volunteers
- 4,000 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Multiple Sclerosis
Post-Authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Mayzent
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to siponimod during pregnancy to treat MS.
- Trial name
- NCT04933552
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 867 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Swiss Multiple Sclerosis Cohort-Study
The Swiss MS Cohort Study (SMSC) is a multicentre cohort study that involves 8 Swiss Multiple Sclerosis centres. The key aims of the SMSC are 1.
- Trial name
- SMSC (NCT02433028)
- Where
- 8 sites in Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis (MS)
Effect of Guided Imagery on Well-being in Patients With Multiple Sclerosis
This single-center interventional study quasi-randomly allocated patients to a guided imagery or control intervention (positive journaling). Data were analyzed with treatment allocation masked.
- Trial name
- HLGI (NCT03177655)
- Testing
- Guided Imagery, Journaling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE)
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring IS medications.
- Conditions
- Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Pemphigus Vulgaris, Multiple Sclerosis (MS)
- Trial name
- NCT05000216
- Testing
- Moderna mRNA-1273, BNT162b2, Ad26.COV2.S
- Where
- 29 sites in United States
- Volunteers
- 258 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Relapsing-Remitting Multiple Sclerosis
A Postmarketing Surveillance (PMS) Study to Evaluate the Extent to Which Patient Compliance is Influenced by Use of a Variable Titration Regimen at the Start of Treatment of Relapsing Multiple Sclerosis (MS) With Interferon Beta 1a (Rebif®)
This was an open-label, multicentric, prospective, post-marketing surveillance (PMS) study on the extent to which subject compliance is influenced by use of a variable titration regimen at the start of treatment of relapsing MS…
- Trial name
- TOURIMS (NCT01142492)
- Testing
- Interferon beta-1a
- Volunteers
- 403 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Acute Myeloid Leukemia
Allogeneic HCT Using Uniform Conditioning Regimen Regardless of Donors (MS, MU, or HF) for AML in Remission
The purpose of this study is to evaluate the effect of various clinical variables including HLA-disparity and NK cell-related variables, upon outcomes of allogeneic hematopoietic cell transplantation (HCT) using uniform…
- Trial name
- AML_AlloHCT (NCT03337568)
- Testing
- allogeneic hematopoietic cell transplantation
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Asan Medical Center
Control Condition
Determining Paediatric Usual Values for Hormones Dosages by LC-MS/MS
Liquid chromatography coupled with mass spectrometry (LC-MS/MS) is now the method of choice for steroid hormone analysis, as it enables analyses to be carried out on small-volume samples on a wider range of hormones, with…
- Trial name
- DOSHOMASS (NCT06694415)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis, Covid19
MS Relapses During COVID-19 Pandemic
Throughout the COVID-19 pandemic, and to our knowledge there have been no studies looking systematically at the occurrence of MS relapses and their subsequent management, during the peak of the first wave of the pandemic.
- Conditions
- Multiple Sclerosis, Covid19, Relapsing Remitting Multiple Sclerosis
- Trial name
- NCT04858763
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Multiple Sclerosis, Pregnancy Related
PREG-MS: New England MS Pregnancy Registry
The purpose of the study is to develop a detailed pregnancy registry of patients with Multiple Sclerosis in the New England states.
- Trial name
- NCT03368157
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
TYSABRI Global Observational Program in Safety
The Primary objective of this study is to determine the incidence and pattern of serious infections, malignancies, and other serious adverse events (SAE) in participants with multiple sclerosis (MS) treated with Tysabri…
- Trial name
- TYGRIS (NCT00477113)
- Where
- United States
- Volunteers
- 2,207 people
- Sponsor
- Biogen
Pompe Disease
Screening for Early Detection and Prevention of Pompe Disease in Israel Using Tandem Mass Spectrometry
The aim of the study is: to develop a comprehensive biochemical assay for detection of Pompe disease (glycogen storage disease type II), to be implemented in the Newborn screening program among the Israeli population.
- Trial name
- LC-MS-MS (NCT01409486)
- Testing
- Drawing blood spots from Newborns
- Where
- Israel
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Neuroinflammatory Diseases, Multiple Sclerosis
FIT-ATOMIC Exercise Feasibility Trial
This multi-center, randomized controlled feasibility trial will assess a 20-week home-based exercise intervention in youth with Multiple Sclerosis (MS).
- Trial name
- FIT-ATOMIC (NCT06870968)
- Testing
- Exercise Training, Mobility and Flexibility Training
- Where
- 4 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children