Clinical trials: Major Surgery
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital
Von Willebrand Disease
A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD)
The main aim of the study is to check effectiveness, side effects, and tolerability of vonicog alfa (recombinant von Willebrand factor [rVWF]), with or without ADVATE, in the treatment and control of nonsurgical bleeding events…
- Trial name
- NCT02932618
- Testing
- Vonicog alfa, Antihemophilic Factor (Recombinant)
- Where
- 46 sites in United States, Austria and 11 more
- Volunteers
- 47 people
- Sponsor
- Baxalta now part of Shire
Severe Hyperglycemia, Postoperative Infection
Intraoperative Hyperglycemia and Infections After Orthopedic Surgery
Postoperative infections are a common complication. A relationship between perioperative severe hyperglycemia and postoperative infections has been found in patients undergoing craniotomy.
- Conditions
- Severe Hyperglycemia, Postoperative Infection, Orthopedic Patients
- Trial name
- NCT03903354
- Testing
- Incidence of infections within 7 days postoperatively
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Federico Bilotta
Covid19, Emergencies
Effect of Covid-19 Pandemic in Non Covid-19 Patients at the Emergency Surgical Department
Introduction Most countries imposed mandatory lockdowns that were rapidly lifted, however Argentina holds the record for one of the longest quarantines in the world.
- Conditions
- Covid19, Emergencies, Appendicitis, Surgical Procedure, Unspecified
- Trial name
- NCT04900233
- Testing
- surgery
- Where
- Argentina
- Volunteers
- 651 people
- Sponsor
- Hospital Italiano de Buenos Aires
Spinal Fusion, Cardiopulmonary Bypass
Point of Care Testing in Pediatric Patients Undergoing Major Surgery
The current study proposes to investigate Point of Care Testing (POCT) (Coagcheck®) and compare obtained results versus standard laboratory coagulation parameters prothrombin time (PT) and partial thromboplastin time (PTT).
- Trial name
- NCT01742936
- Testing
- CoaguChek, Hospital Laboratory
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nationwide Children's Hospital
Severe Sepsis, Organ Dysfunction Syndrome
Effect of Docosahexaenoic Acid on the Inflammatory Response and Clinical Outcomes From Surgical Patients
The purpose of this study is to evaluate if enteral docosahexaenoic acid (DHA) administration attenuates the inflammatory cytokines and improve clinical outcomes in neonates who underwent cardiovascular surgery
- Trial name
- DHA-IRCO (NCT01049529)
- Testing
- Docosahexaenoic acid
- Where
- Mexico
- Volunteers
- 55 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Rheumatic Heart Disease
Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge
Rhumatic heart disease patients with mitral regurge untile know had adibat for timming of surgical interferance our study aim to solve this problme using a new technic in echocardiography called speckle tracking which is more…
- Trial name
- NCT03156972
- Testing
- Replacment of mitral valve
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mohammed mahmoud mohammed othman
High Grade Sarcoma, Sarcoma
Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial
This phase II trial compares standard of care surgical resection to fluorescence-guided surgical resection using indocyanine green and fluorescence imaging for reducing unexpected positive margin rates in patients with sarcoma.
- Trial name
- NCT07650656
- Testing
- Electronic Health Record Review, Fluorescence Imaging, Fluorescence-Guided Surgery
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Pygopagus Conjoined Twins, Separation Surgery
The Importance of Physiotherapy After Separation Surgery in Pygopagus Conjoined Twins
Motor function delays are observed in pygopagus conjoined twins due to limited movement experience and deficits in proprioceptive sense.
- Conditions
- Pygopagus Conjoined Twins, Separation Surgery, Pediatric Physiotherapy
- Trial name
- NCT06599281
- Testing
- Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people
- Sponsor
- Acıbadem Atunizade Hospital
Obesity, Surgery
Laparoscopic Sleeve Gastrectomy in Severely Obese Adolescents: Effects on Metabolism
Severe obesity (SO), defined as BMI≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3-2.8% of 12-19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one…
- Trial name
- NCT02594514
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Bypass Surgery
CD0104 VEST II Post Marketing Surveillance Study
This study is designed to collect post market data on use of the VEST, particularly on saphenous vein grafts to the right territory of the heart.
- Trial name
- VEST II (NCT02332330)
- Testing
- VEST
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Vascular Graft Solutions Ltd.
Hypovolemia
Prediction of Fluid Responsiveness in Children Undergoing Major Surgery
The purpose of this study is to evaluate predictability of a respiratory variation in pulse oximeter plethysmography for fluid responsiveness in children undergoing major surgery.
- Trial name
- NCT02952651
- Testing
- Pulse oximeter
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Congenital Disorders, Cerebral Desaturation
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1.
- Conditions
- Congenital Disorders, Cerebral Desaturation, Neonatal Surgery
- Trial name
- NCT05673499
- Testing
- NIRS/EEG monitoring
- Where
- 15 sites in United States, Australia and 5 more
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Philadelphia
Surgery, Anesthesia
Comparing the Effectiveness of Modified ERAS Protocols vs. Standard Management in Pediatric Gastrointestinal Surgery
Perioperative management of pediatric patients with gastrointestinal diseases involves a fairly length process and which can lead to rapid deterioration even death.
- Trial name
- NCT06981572
- Testing
- Modified Enhanced Recovery After Surgery Protocol
- Where
- Indonesia
- Volunteers
- 82 people
- Sponsor
- Universitas Indonesia
Hip Fracture, Blood Loss
Can Thrombelastography Predict Blood Loss in Patients With Hip Fractures
Hip fractures are associated with a large hidden blood loss. That is, the total blood loss associated with hip fracture surgery is much greater than that observed intra operatively.
- Trial name
- NCT02297061
- Testing
- Thrombelastography analysis (TEG)
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Hvidovre University Hospital
Preoperative Anxiety
Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery
Preoperative anxiety is a common issue in pediatric anesthesia. Children often experience anxiety and uneasiness due to uncertain outcomes.
- Trial name
- NCT06489327
- Testing
- melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg
- Where
- 2 sites in Egypt, Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Breast Cancer, Pain
CWI and Discharge After Breast Cancer Surgery
The objectives of this work are threefold: 1. To evaluate the analgesic efficacy of CWI in women discharged within 23 hours of major breast cancer surgery 2.
- Trial name
- NCT02897934
- Testing
- Bupivacaine continuous infusion
- Where
- Ireland
- Volunteers
- 10 people
- Sponsor
- University College Cork
LAD (Left Anterior Descending) Coronary Artery Stenosis
Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique
The objective of this study is to compare different surgical strategies for management of severely diseased LAD artery during CABG i.e. LIMA on-lay patch vs.
- Trial name
- NCT06835114
- Testing
- CABG, LIMA on lay patch, Safenous vein patch
- Volunteers
- 90 people
- Sponsor
- Assiut University