Clinical trials: Mass Spectrometry
Endocrine Disorders
Salivary Cortisol Measurements by Mass Spectrometry
Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace…
- Trial name
- NCT02162706
- Testing
- Non intervention study
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Metabolic Disease, Obesity, Infant
Metabotyping of Overweight and Obese Children
Today's children are increasingly facing metabolic-related health issues, among which the worldwide prevalence of overweight and obesity is rising at an alarming pace.
- Trial name
- RecSAMP (NCT04632511)
- Testing
- MetaSAMP
- Where
- 10 sites in Belgium
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pediatric Medulloblastoma
Metabolomic Analysis of Body Fluid of Medulloblastoma in Children
Based on a new mass spectrometry system, body fluid samples were analyzed to verify the role of metabolite analysis in the diagnosis of pediatric medulloblastoma.
- Trial name
- NCT04065204
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Afebrile Seizure (Finding)
Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure
Before the age of 14 years, 1% of the paediatric population will develop a seizure. The only systematically required complementary examination is an electroencephalogram (EEG).
- Trial name
- CASTox (NCT03310697)
- Testing
- Collection of blood and urine samples, Clinical examination
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Toulouse
PKU
Determining the Most Efficient Screening Cut Off Levels for Phenylketonuria (PKU)
studying the screening of PKU in france with the new tandemMS
- Trial name
- NCT06629987
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Central Hospital, Nancy, France
Validate Volumetric Absorptive Microsampling (VAMS) Assay
Tacrolimus Microsampling
This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients who have undergone heart transplantation who meet eligibility requirements will be approached to participate in the study.
- Trial name
- VAMS (NCT04810143)
- Testing
- Mitra Microsampler
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bacterial Infections, Fungal Infections
MALDITOF Versus Routine Clinical Microbiology for Identifying Pathogens; a Randomized Diagnostic Trial
MALDI-TOF MS is capable of directly identifying bacteria and fungi in positive blood cultures, which may be beneficial to patient management.
- Trial name
- MALDITOF (NCT02306330)
- Testing
- Malditof, Routine clinical microbiology
- Where
- 2 sites in Vietnam
- Volunteers
- 802 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Cystic Fibrosis
Pathogenicity of Species of the Achromobacter Genus in Patients From Reunion Island With Cystic Fibrosis
The pathogenicity of Achromobacter bacteria is not yet well established, but studies show a decline in respiratory function and an increase in mortality associated with chronic colonisation, making it possible to classify the…
- Trial name
- ACHROMO-MUCO (NCT06371261)
- Testing
- Biological analyses
- Where
- 2 sites in Reunion
- Volunteers
- 17 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Fatty Acid Metabolism
Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo
We will test the following hypotheses: 1. The activity of the desaturating/elongating enzymes assessed by the in vivo conversion of deuterated a-linolenic and linoleic acids to DHA and AA, respectively, will be related to the…
- Trial name
- NCT00342303
- Where
- 2 sites in Chile
- Volunteers
- 110 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Juvenile Idiopathic Arthritis, Arthritis, Septic
Rapid Diagnostic Test for Septic Arthritis
Diagnostic Validation Study of a Test Based on the Analysis of the Proteome by Mass Spectrometry for the Diagnosis of Septic Arthritis in Children Under 16 Years of Age
- Conditions
- Juvenile Idiopathic Arthritis, Arthritis, Septic, Arthritis, Unspecified
- Trial name
- TDR-Arthrite (NCT04460144)
- Testing
- Mass spectrometry
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Esophagus Adenocarcinoma, Esophagus Cancer
Oncometabolome and MALDI-MSI in Upper GI Carcinomas - Chemosensitivity in Esophageal Carcinoma
Locally advanced adenocarcinoma of the esophagus is a leading cause of death from malignant disease in Germany and has been characterized on a molecular level in recent years.
- Conditions
- Esophagus Adenocarcinoma, Esophagus Cancer, Metabolome, Mass Spectrometry
- Trial name
- NCT06642506
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Opioid Use, Unspecified
Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
Hair analysis is a well-established and important tool in both forensic and clinical context. When it comes to the interpretation of positive hair analysis results, reliable and comprehensive reference data is essential.
- Trial name
- NCT05740657
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University
Drug Abuse
Hospitalisations of Teenagers and Young Adulthoods in Mayotte After Consumption of an Illegal Drug Called " Chimique ", Which Substances Are Incriminated ? : HOMACHI
The study aims (i) to identify which substances leading to hospitalizations at Mayotte are also called "chimique" and (ii) to correlate these substances with clinical pictures in order to favor a better approach of the treatments.
- Trial name
- HOMACHI (NCT04547751)
- Testing
- targeted high-resolution mass spectrometry
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bordeaux
Brain Diseases
Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery…
- Trial name
- NCT00592709
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus
Evaluation and Validation of New Biomarkers by Mass Spectrometry
The investigators will perform biochemical and metabolic evaluations on cord blood, venous blood of the mother and urine of the foetus and mother using time-of-flight and tandem mass spectrometry.
- Trial name
- DG7 (NCT01025973)
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke