Clinical trials: Maternal Diabetes
Type2 Diabetes, Gestational Diabetes
Metabolic Risk and Life Style Factors in Women With Previous Gestational Diabetes Mellitus (GDM)
Women with previous Gestational Diabetes Mellitus (GDM) are characterized by several metabolic abnormalities i.e. insulin resistance, beta-cell dysfunction and increased risk of later Diabetes Mellitus (DM).
- Conditions
- Type2 Diabetes, Gestational Diabetes, Life Style
- Trial name
- NCT03050645
- Where
- Denmark
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Gestational Diabetes Mellitus as Antepartum Condition
Glycemic Impact of Myo-inositol in Pregnancy
Myo-inositol has been shown to decrease the rate of diabetes in pregnancy in European studies. It is not known exactly how this occurs or what it does to the sugar when the supplement is taken.
- Trial name
- NCT02149992
- Testing
- myo-inositol, Continuous glucose monitoring surveillance, Glucose monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Gestational Diabetes, Type2 Diabetes
The Belgian Diabetes in Pregnancy Follow-up Study
Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. GDM is associated with increased risks for pregnancy complications such as macrosomia s and preterm delivery.
- Conditions
- Gestational Diabetes, Type2 Diabetes, Obesity
- Trial name
- BEDIP-FUS (NCT04429958)
- Testing
- GDM
- Where
- 5 sites in Belgium
- Volunteers
- 630 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Diabetes Mellitus, Diabetes Mellitus, Type 1
An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
This study is conducted in Europe and Asia. The purpose of the study (Diabetes Pregnancy Registry) is to evaluate the safety of treatment with insulin detemir in pregnant women with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01892319
- Testing
- insulin detemir, other injectable antidiabetic treatment regimens
- Where
- 93 sites in Croatia, Finland and 14 more
- Volunteers
- 2,446 people
- Sponsor
- Novo Nordisk A/S
Gestational Weight Gain, Diet, Healthy
Delivering HOPE (Helping Women Optimize Prenatal Equity)
The overarching research question is: "Does the provision of healthy food (Delivering HOPE) during pregnancy reduce the proportion of women who experience excessive gestational weight gain compared with enhanced standard of care…
- Conditions
- Gestational Weight Gain, Diet, Healthy, Gestational Hypertension, Gestational Diabetes
- Trial name
- NCT06814509
- Testing
- Enhanced Standard of Care (ESoC), Delivering HOPE
- Where
- 8 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Pregnancy, Gestational Diabetes
A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS
The aim of this open label feasibility study is to determine recruitment rates to a randomised trial of glibenclamide compared with insulin (both in addition to maximum tolerated metformin) for the treatment of Gestational…
- Trial name
- GRACES (NCT02080377)
- Testing
- Glibenclamide, Insulin
- Where
- 5 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Edinburgh
Type 1 Diabetes
Study of Offspring of Women With Type 1 Diabetes
There is an increasing trend in the society for developing obesity, type 2 diabetes and cardiovascular diseases. It is therefore important to identify the risk factors behind this tendency.
- Trial name
- EPICOM (NCT01559181)
- Where
- 3 sites in Denmark
- Volunteers
- 584 people
- Sponsor
- Odense University Hospital
Gestational Diabetes Mellitus, Class A2
Failure Rate of GLyburide And Metformin Among Gestational Diabetics
A pragmatic, comparative effectiveness trial of glyburide versus metformin.
- Trial name
- GLAM (NCT03078725)
- Testing
- Glyburide, Metformin
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Gestational Diabetes Mellitus in Pregnancy, Hypertension ,Pregnancy
Impact of Behavioural Modification Working Toolkit Among Women With Gestational Diabetes Mellitus and Hypertension
This trial aims to evaluate the effectiveness of a Behavioral Modification Working (BMW) Toolkit in improving glycemic control and blood pressure among pregnant women diagnosed with both GDM and PIH.
- Trial name
- NCT07551011
- Testing
- Behavioral Modification Working (BMW) Toolkit, Routine Antenatal Care
- Where
- 2 sites in Pakistan
- Volunteers
- 220 people
- Sponsor
- University of the Punjab
Weight Gain, Maternal; Diabetes Mellitus, Affecting Fetus
Tongji Maternal and Child Health Cohort
This is a population-based study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health…
- Conditions
- Weight Gain, Maternal; Diabetes Mellitus, Affecting Fetus, Diet Habit, Pregnancy Complications
- Trial name
- TMCHC (NCT03099837)
- Volunteers
- 8,649 people
- Sponsor
- Huazhong University of Science and Technology
Gestational Diabetes Mellitus in Pregnancy, Vitamin D Deficiency
Effects of Vitamin D Supplementation on Glucose Metabolism in Women With Former Gestational Diabetes Mellitus
Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta-cell function, with heightened risk for future development of diabetes.
- Trial name
- NCT01992133
- Testing
- Vitamin D3
- Where
- Malaysia
- Volunteers
- 26 people
- Sponsor
- RCSI & UCD Malaysia Campus
Gestational Diabetes Mellitus
Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring
The rapidly rising risk of gestational diabetes pregnant women demands that an effective diet strategy be developed due to the high risk of fetal overgrowth, which places the newborn at increased risk for childhood obesity and…
- Trial name
- CHOICE (NCT02244814)
- Testing
- Low Carbohydrate/Conventional, Choosing Healthy Options in Carbohydrate Energy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Colorado, Denver
Diabetes in Pregnancy, Diabetes, Gestational
Effect of Maternal Diabetes on Brain Development, as Measured by Neonatal Electroencephalogram (EEG)
Alterations in the intrauterine environment can have profound effects on fetal development. Diabetes during gestation results in multiple deleterious short-term outcome differences, and is correlated with long-term developmental…
- Conditions
- Diabetes in Pregnancy, Diabetes, Gestational, Infant, Newborn, Diseases, Perinatal Disorders of Growth and Development
- Trial name
- NCT02968628
- Testing
- Video Electroencephalogram (EEG), Point-of Care Blood Sugar Testing, Medical Record Data Extraction
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Diabetes, Gestational, Pregnancy Diabetic
Long-term Outcome After Gestational Diabetes and Diabetes in Pregnancy
The primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring.
- Trial name
- MuKiLOG (NCT04417452)
- Testing
- Basic data collection (online survey or written form), Physical examination, Psychometric examination
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Gestational Diabetes Mellitus (GDM)
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks' gestation…
- Trial name
- EAGER Pilot (NCT06641141)
- Testing
- Induction of Labour
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Ottawa Hospital Research Institute
Gestational Diabetes
Intergenerational Programming of Diabesity in Offspring of Women With Gestational Diabetes Mellitus
India is one of the diabetes capitals in the world. Indians are susceptible to develop diabetes at a younger age and at a lower BMI compared to Europeans.
- Trial name
- InDiaGDM (NCT03388723)
- Where
- India
- Volunteers
- 1,178 people, healthy volunteers welcome
- Sponsor
- Kem Hospital, Pune, India
Gestational Diabetes
Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus
GUARD is a Clinical Trial that wants to explore the impact of UDCA compared to metformin in the treatment of GDM. The trial wants to recruit 158 women who are overweight or obese who have been diagnosed with GDM, and require…
- Trial name
- GUARD (NCT04407650)
- Testing
- Metformin, Ursodeoxycholic Acid
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- King's College London
Hypoglycemia
Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers
Thesis Infants of diabetic mothers are at high risk to develop hypoglycemia after birth. After birth, glucose and ketone bodies are the main substrates of brain energy.
- Trial name
- NCT00434772
- Testing
- glucagon
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Healthy Volunteers
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants
This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors…
- Trial name
- NCT04286464
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern