Clinical trials: Mechanically Ventilated Patients
Critical Illness
Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients
The purpose of this study is to determine whether oral topic silver nanoparticles are effective to reduce potential pathogen microbial loads in mechanical ventilation patients.
- Trial name
- NCT02761525
- Testing
- silver nanoparticles
- Volunteers
- 50 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Critical Illness, Invasive Mechanical Ventilation
MOdifiable facTors to Improve VentilAtion ThErapy in ICU
ABSTRACT Introduction: Invasively ventilated patients in low and middle-income countries (LMICs) experience significantly higher mortality compared to those in High income countries (HICs).
- Conditions
- Critical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
- Trial name
- MOTIVATE-ICU (NCT06288724)
- Volunteers
- 625 people
- Sponsor
- Nat Intensive Care Surveillance - MORU
Mechanical Ventilation
Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients
The purpose of this study is to evaluate the effect of BYM338 on muscle mass and function in Group III failure to wean patients, as compared to placebo controls.
- Trial name
- NCT01868685
- Testing
- BYM338
- Sponsor
- Novartis Pharmaceuticals
Nursing Caries, Practice Nurse's Scope
Effect of Evidence-based Nursing Practices Training Program on the Competency of Nurses Caring for Mechanically Ventilated Patients
the overall aim of this study is to examine the effect of adapted Evidence-based nursing practices training program on the competency level of nurses caring for Mechanically ventilated patients in selected ICU in Egypt.
- Conditions
- Nursing Caries, Practice Nurse's Scope, Competence
- Trial name
- NCT05721664
- Testing
- Trianing program for nurse in how to provide evidence based practices for mechanically Ventilated Patients
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Anesthesia, Intravenous Fluid
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.
- Conditions
- Anesthesia, Intravenous Fluid, Blood Pressure
- Trial name
- NCT03431064
- Testing
- Lung Recruitment Maneuver, Fluid Administration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Boston Children's Hospital
Dyspnea During Mechanical Ventilation
Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients
The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.
- Trial name
- NCT07205952
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas José de San Martín
Mechanically Ventilated Children Admitted to the Pediatric Intensive Care Unit
Impact of Sedation Practices on Clinical Outcomes Among Mechanically Ventilated Children
evaluate the impact of sedation adequacy on clinical outcomes in mechanically ventilated children admitted to the pediatric intensive care unit (PICU).
- Trial name
- ISPMVC (NCT07821268)
- Testing
- no need
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Yasmine Ahmed Abdelrahman
Critical Illness, Sedation
Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients
The purpose of this study is to investigate the efficacy and safety of a low dose ketamine infusion used in combination of standard of care in critically ill patients to test whether ketamine can help to shorten the time of being…
- Conditions
- Critical Illness, Sedation, Mechanical Ventilation
- Trial name
- ATTAINMENT (NCT04075006)
- Testing
- Ketamine
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Respiration, Artificial
Feasibility of Ventilation Detection Via Standard Defibrillator Pads in Mechanically Ventilated Pediatric Patients
This study is a prospective, observational case series of a convenience sample of mechanically ventilated pediatric patients in the Pediatric ICU, Progressive Care Unit and Operating Room at the Children's Hospital of…
- Trial name
- Vent Detection (NCT00628875)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Mechanical Ventilation Complication, Physical Disability
Manual Hyperinflation and Physical Therapy Program on Lung Recruitment Mechanically Ventilated Pediatric Patients
The purpose of this study is to investigate the immediate combined effects of Manual Hyperinflation and standard Physical therapy program on lung recruitment and secretion mass in mechanically ventilated pediatric patients aged…
- Trial name
- MHI (NCT06349785)
- Testing
- rehabilitation of mechanically ventilated patients, supportive care
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- New Ismailia National University
Sepsis
Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Despite of a remarkable decrease in overall mortality has been achieved following the International Guidelines for Management of Sepsis and Septic Shock since 2004,the short-and long-term outcomes remain poor in critically ill…
- Trial name
- PTMVP (NCT03406494)
- Testing
- Early multicomponent physical therapy program
- Volunteers
- 800 people
- Sponsor
- Zhujiang Hospital
Atelectasis
Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient
The purpose of this study is to evaluate whether a therapy that uses a machine called a continuous high frequency oscillator (CHFO) is more successful at removing mucus than medications that thin out the mucus.
- Trial name
- NCT02168387
- Testing
- continuous high frequency oscillator (CHFO), Acetylcysteine, dornase alfa
- Volunteers
- 39 people
- Sponsor
- Duke University
Heart Failure
B-line by Lung US in Patients With Acute Decompensated Heart Failure
The purpose of this study is to evaluate that B-line detected by lung ultrasound before extubation in patients with acute decompensated heart failure can predict future risk of reintubation and clinical outcomes during admission…
- Trial name
- NCT04322851
- Testing
- Lung ultrasound
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Sedation
Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
This is a study to compare safety and efficacy of inhaled isoflurane delivered by the AnaConDa-S (Anaesthetic Conserving Device (ACD)) versus intravenous midazolam for sedation in mechanically ventilated children admitted to an…
- Trial name
- IsoCOMFORT (NCT04684238)
- Testing
- Midazolam, Isoflurane
- Where
- 24 sites in France, Germany and 3 more
- Volunteers
- 94 people
- Sponsor
- Sedana Medical
Intensive Care Units, Pediatric, Anesthetics, Inhalation
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce…
- Conditions
- Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
- Trial name
- ABOVE (NCT05867472)
- Testing
- Isoflurane Inhalant Product
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Failure
Dexmedetomidine Pharmacokinetics-pharmacodynamics in Mechanically Ventilated Children With Single-organ Respiratory Failure
Currently, dexmedetomidine is approved by the United States Food and Drug Administration (FDA) for short-term analgosedation (<24h) in mechanically-ventilated critical care adult patients and sedation of non-intubated adult…
- Trial name
- NCT01076816
- Testing
- dexmedetomidine, Vital signs, blood sampling
- Where
- 2 sites in Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Eye Care, Nursing Care
Effects of Two Different Eye Care Practices on Eye Complications in Mechanically Ventilated Intensive Care Patients
This study was designed as a prospective, randomized controlled experimental study aiming to compare different approaches to eye care in intensive care patients receiving mechanical ventilation.
- Conditions
- Eye Care, Nursing Care, Intensive Care Unit
- Trial name
- NCT07070843
- Testing
- Control Group: Standard Eye Care Group, Intervention Group 1: Eye Care Using an Eye Care Kit, Intervention Group 2: Eye Care According to an Eye Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Istanbul Saglik Bilimleri University
Respiratory Support
The ACCESSIT Study
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
- Trial name
- ACCESSIT (NCT05207046)
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Failure
Timing of Target Enteral Feeding in the Mechanically Ventilated Patient
This study tests the hypothesis that initial trophic enteral feedings will increase the time alive and free of mechanical ventilation as compared to initial goal enteral feedings in patients who are mechanically ventilated.
- Trial name
- NCT00252616
- Testing
- trophic enteral feeds
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University