Clinical trials: Medication Systems
HIV Infections
A Phase III Randomized Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of 3TC/ZDV/1592U89 and 3TC/ZDV/IDV in HIV-1 Infected Antiretroviral Therapy-Naive Subjects.
To compare the safety, tolerance, early antiviral activity, and durability of antiviral response of the lamivudine (3TC)/zidovudine (ZDV)/1592U89 arm versus the 3TC/ZDV/indinavir (IDV) arm.
- Trial name
- NCT00002199
- Testing
- Indinavir sulfate, Lamivudine/Zidovudine, Abacavir sulfate
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Glaxo Wellcome
Acute Lymphoblastic Leukemia
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission
This randomized phase III trial studies compliance to a mercaptopurine treatment intervention compared to standard of care in younger patients with acute lymphoblastic leukemia that has had a decrease in or disappearance of signs…
- Trial name
- NCT01503632
- Testing
- Behavioral Intervention, Compliance Monitoring, Laboratory Biomarker Analysis
- Where
- 102 sites in United States, Puerto Rico
- Volunteers
- 570 people
- Sponsor
- Children's Oncology Group
Rheumatoid Arthritis
Safety Study of Abatacept to Treat Rheumatoid Arthritis (A)
The purpose of this study is to compare the incidence rates of infection among patients with rheumatoid arthritis who are treated with abatacept and those who are treated with other anti-rheumatic medications
- Trial name
- NCT01088321
- Volunteers
- 81,332 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
A Study of Thymic Humoral Factor (THF Gamma 2) in HIV-Infected Patients
To investigate the safety of thymic humoral factor (THF gamma 2), its effect on HIV load based on at least a 75 percent decrease in HIV quantitative PCR RNA copies/ml, and its persistence when administered in combination with an…
- Trial name
- NCT00002435
- Testing
- Thymic Humoral Factor, Zidovudine
- Where
- 10 sites in United States
- Sponsor
- Pharmacia
Short Bowel Syndrome
A Study of Teduglutide in Japanese Children With Short Bowel Syndrome Aged 4 Months or Older
The main aims of the study are to check for side effects from teduglutide. Participants will receive a daily injection of teduglutide just under the skin (subcutaneous) for 24 weeks. Then they are followed up for another 4 weeks.
- Trial name
- NCT05027308
- Testing
- Teduglutide
- Where
- 6 sites in Japan
- Volunteers
- 3 people
- Sponsor
- Takeda
HIV Infections
Handheld Computers to Improve Adherence to Anti-HIV Drug Regimens
While anti-HIV drugs can significantly reduce viral loads, the medication regimens can be complex, and patients must take them correctly for the best effect. Nonadherent patients risk developing drug resistant HIV strains.
- Trial name
- NCT00053443
- Testing
- Medication Reminder System/Adherence Tracker
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Paraplegia and Tetraplegia
Healthcare Professionals' Satisfaction With Various Exoskeleton Models
The recent increase in the use of exoskeletons in rehabilitation therapies is bringing important changes to the healthcare professional's work routine.
- Trial name
- NCT07767955
- Testing
- Exoskeleton
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Lymphoid Leukemia, Acute Myeloid Leukemia
Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies
This is an open-label, multicenter, phase 2 clinical trial to evaluate the antitumor activity of brentuximab vedotin as a single agent in patients with CD30-positive nonlymphomatous malignancies.
- Conditions
- Acute Lymphoid Leukemia, Acute Myeloid Leukemia, Anemia, Refractory, With Excess of Blasts, Solid Tumors
- Trial name
- NCT01461538
- Testing
- brentuximab vedotin
- Where
- 29 sites in United States
- Volunteers
- 84 people
- Sponsor
- Seagen Inc.
Tic Disorders
Efficacy of Biofeedback in the Treatment of Tic Disorder
To investigate the efficacy of EEG biofeedback and drug therapy in the treatment of tic disorders
- Trial name
- NCT05361993
- Testing
- Drug Aripiprazole, biofeedback
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Condomless Sex, Human Immunodeficiency Virus (HIV)
Cape Town Young Women's Health CoOp
This two-arm cluster randomized trial tested a gender-focused comprehensive HIV testing and counselling (HTC) program, the Young Women's Health CoOp (YWHC) with a standard HTC program and targeted female adolescents (aged 16-19)…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug Use
- Trial name
- NCT02974998
- Testing
- Young Women's Health CoOp (YWHC), Standard HTC
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RTI International
HIV Infections
A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate levels from becoming too high in patients who are taking nucleoside reverse transcriptase inhibitor (NRTI) anti-HIV drugs.
- Trial name
- NCT00037063
- Testing
- Thiamine hydrochloride, Riboflavin, Ascorbic acid
- Where
- 4 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hematologic Malignancies, Nonmalignant Diseases
Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)
Fludarabine and clofarabine are chemotherapy drugs used extensively in bone marrow transplantation. The goal of this study is to determine what causes some children to have different drug concentrations of clofarabine and…
- Conditions
- Hematologic Malignancies, Nonmalignant Diseases, Immunodeficiencies, Hemoglobinopathies
- Trial name
- NCT03609814
- Testing
- Clofarabine, Fludarabine Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
HIV Infections
A Study of Dideoxyinosine (ddI) in HIV-Infected Children Who Have Not Had Success With Zidovudine or Who Cannot Take Zidovudine
To evaluate the effectiveness, safety, and tolerance of two doses of didanosine (ddI) in the treatment of children with symptomatic HIV disease who have had to discontinue zidovudine (AZT) because of intolerance and/or who have…
- Trial name
- NCT00000963
- Testing
- Didanosine
- Where
- 52 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphoma, T-Cell, Peripheral
A Retrospective Study of Clinical, Phenotypic and Genetic Factors of Peripheral T-Cell Lymphomas
The purpose of this study is to establish the distribution of peripheral T-cell lymphocyte (PTCL) subtypes by re-analysis and re-classification of samples according to the 2008 World Health Organization (WHO) classification of…
- Trial name
- NCT02788916
- Testing
- No Intervention
- Where
- 10 sites in Spain
- Volunteers
- 198 people
- Sponsor
- Takeda
Neurofibromatosis 1, Neurofibroma, Plexiform
Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder. It has a broad variety of effects on the body. Up to half of people with NF1 get plexiform neurofibromas (PNs). These are benign tumors.
- Trial name
- NCT03531814
- Testing
- Medication Event Monitoring System (MEMS^TM), Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Inflammatory Bowel Disease
Immune Function in Offsprings of Females With Inflammatory Bowel Disease
1. To evaluate the immune response to vaccines in infants of IBD patients treated with anti-TNF medications during pregnancy compared to infants of IBD mother not treated with anti-TNF medications. 2.
- Trial name
- NCT02079441
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Intractable Epilepsy
The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy
The primary aim of the study is to determine the effect of reducing the number and/or dose of anti epileptic drugs on an individual's quality of life and seizure control in people with difficult to control epilepsy and who are on…
- Trial name
- NCT00647322
- Testing
- Reduction of anti-epileptic medications, No drug change
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- Institute of Child Health
HIV Infections
Faster Identification of TB and Evaluation of Drug Resistance in HIV-infected People
Early identification of tuberculosis (TB) is of particular importance in HIV-infected individuals, as a delay of therapy can be devastating in those with compromised immune systems.
- Trial name
- FASTER (NCT00959088)
- Where
- 3 sites in Brazil, Peru and 1 more
- Volunteers
- 641 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Crohn's Disease, Ulcerative Colitis
Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02862132
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Denmark and 4 more
- Volunteers
- 142 people
- Sponsor
- Shaare Zedek Medical Center
Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
This clinical trial is looking at a drug called atezolizumab. Atezolizumab is approved as standard of care treatment for adult patients with urothelial cancer, non-small cell lung cancer, extensive-stage small cell lung cancer…
- Conditions
- Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT05770102)
- Testing
- Atezolizumab
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
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