Clinical trials: Meningomyelocele
Sleep-disordered Breathing, Myelomeningocele
Sleep-disordered Breathing in Infants With Myelomeningocele
This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs.
- Trial name
- NCT04251806
- Testing
- neonatal polysomnography, 2-year Bayley Exam, 2-year polysomnography
- Where
- 9 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Michigan
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Meningomyelocele
Dual Task and Upper Extremity Performance in Children With Myelomeningocele
Myelomeningocele is a neural tube defect caused by the failure of the neural tube to close in the caudal part. The exposed spinal cord in myelomeningocele usually causes neural damage.
- Trial name
- NCT06949475
- Testing
- Single Task (Box and Block Test), Single Task (Nine Hole Peg Test), Dual Task (Box and Block Test-Kognitif Task)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Physical Therapy Modalities
Effects of Physical Therapy Associated With Photobiomodulation on Myelomeningocele
Myelomeningocele is a severe type of spina bifida, resulting from improper closure of the neural tube. This condition drastically affects the structures of the spinal cord, as a result the spinal cord, nerve roots and meninges…
- Trial name
- NCT04425330
- Testing
- physiotherapy exercises, PBM
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Neurogenic Bladder
Efficacy Of Pulsed Electromagnetic Field Therapy On Neurogenic Bladder in Children With Myelomeningocele
This study was conducted to assess the efficacy of pulsed electromagnetic field therapy on neurogenic bladder in children with myelomeningocele .Intervention: A pretest-post test controlled study was conducted in out-patient…
- Trial name
- NCT04187027
- Testing
- pulsed electromagnetic field therapy device
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- South Valley University
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Neurogenic Detrusor Overactivity
A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity.
- Trial name
- NCT00712322
- Testing
- Darifenacin
- Where
- 12 sites in United States, Colombia
- Volunteers
- 35 people
- Sponsor
- Warner Chilcott
Myelomeningocele, Extubation Time
Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of…
- Conditions
- Myelomeningocele, Extubation Time, Neonatal
- Trial name
- MEROX (NCT07465055)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Cerebral Palsy, Myelomeningocele
Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
Barriers to keeping and maintaining fitness as a young person with a disability exist across many domains of access to community locations such as fitness centers, so looking outside of these establishments may be necessary to…
- Conditions
- Cerebral Palsy, Myelomeningocele, Arthrogryposis, Motor Skills Disorders
- Trial name
- NCT04789746
- Testing
- adapted Chicago Run running program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Myelomeningocele
Role of Perforator Flaps in Back Defects Reconstruction
evaluation of perforator flaps versus perforator plus flaps
- Trial name
- NCT06405698
- Testing
- surgical closure of myelomeningocele defects by perforator flaps, surgical closure of myelomeningocele defects by perforator-plus flaps
- Volunteers
- 30 people
- Sponsor
- Assiut University
Spina Bifida, Myelomeningocele
Incontinence and Quality of Life in Children With Spina Bifida
This study aims to develop an innovative, interactive tool for joint use by spina bifida patients and their urologists to identify patients interested in addressing their urinary and fecal incontinence and establish continence…
- Trial name
- NCT03410667
- Testing
- Phase One: Exploration, Phase Two: Creation, Phase Three: Reflection
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Indiana University
Neurogenic Bladder, Myelomeningocele
Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative…
- Trial name
- NCT03550898
- Testing
- Dynamic Ultrasonography
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Urologic Diseases
Outcomes of Proactive Management of Children With Myelomeningocele
Spina bifida birth prevalence in Africa is 0.13%. Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Treatment of neuropathic bladder secondary to spina bifida is an ongoing challenge.
- Trial name
- NCT06301802
- Testing
- CIC, Anticholinergic
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myelomeningocele, Spinal Cord Injury
Reciprocating Gait Orthoses for Paraplegia Patients
Ambulation would bring many physiological and psychological benefits and getting up and walking has been a dream for paraplegia patients.The reciprocating gait orthoses (RGOs) for paraplegics particularly draws research…
- Conditions
- Myelomeningocele, Spinal Cord Injury, Spinal Muscular Atrophy
- Trial name
- UPGO (NCT02227407)
- Testing
- RGOs(reciprocating gait orthoses)
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Myelomeningocele, Spina Bifida
Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida
A study to use transcutaneous spinal cord stimulation to characterize sensorimotor deficits in a pediatric population of individuals with spina bifida.
- Trial name
- NCT06918119
- Testing
- Transcutaneous stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Bacteriuria
Bacteriuria Eradication Through Probiotics
Many children who catheterize their bladders because of spina bifida or other neurologic disorders have bacteriuria. This can lead to urinary tract infections by bacteria from the gut which colonize the vagina and are carried…
- Trial name
- BERP (NCT00717600)
- Testing
- Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Meningomyelocele
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood.
- Trial name
- NCT04027374
- Testing
- Fetal surgery for MMC repair
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Myelomeningocele, Brain Malformation
The Role of CSF in Chiari II Brain Malformation
Spina bifida, particularly its most severe form known as open spina bifida (myelomeningocele), is a significant congenital disorder that results in profound neurological impairments, including Chiari II malformation.
- Conditions
- Myelomeningocele, Brain Malformation, Chiari Malformation Type 2
- Trial name
- NCT06560788
- Testing
- collection of cerebrospinal fluid
- Volunteers
- 18 people
- Sponsor
- University College, London
Myelomeningocele, Prone Position
Cuff Pressure in Infants
The changes in the cuff pressure in the absence of nitrous oxide are less clear.In the current study, we aim to determine the changes in cuff pressure over time in infants undergoing myelomeningocele repair in prone position…
- Trial name
- NCT03088761
- Testing
- cuffed tracheal tube
- Volunteers
- 20 people
- Sponsor
- Istanbul Science University