Clinical trials: Metabolic Testing
Phenylketonuria (PKU)
Simple Breath Test to Examine Phenylalanine Metabolism
Phenylketonuria(PKU)is a rare condition caused by the body's inability to properly breakdown an amino acid called phenylalanine(PHE), due to a missing enzyme, phenylalanine hydroxylase(PAH).
- Trial name
- NCT02009904
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 1 Diabetes Mellitus
Cognitive Adaptations to Reduce Emotional Stress Associated With Type 1 Diabetes
The purpose of this study is to evaluate a new intervention (CARES: Cognitive Adaptations to Reduce Emotional Stress Associated with Type 1 Diabetes) designed to reduce caregiver depressive symptoms in families of children with…
- Trial name
- CARES (NCT03698708)
- Testing
- CARES Intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Kansas Medical Center
Prader Willi Syndrome, Adrenal Insufficiency
Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome
The purpose of this study is to determine presence of central adrenal insufficiency in children with Prader Willi Syndrome using low dose (1 mcg) ACTH stimulation test compared to results of overnight metyrapone test.
- Trial name
- NCT02368379
- Testing
- Low dose (1 mcg) ACTH stimulation test, Overnight metyrapone test
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Obesity
The Impact of Bariatric Surgery Induced Weight Loss on Lung Function in Adolescents
In this prospective study we will evaluate the changes in respiratory physiology occurring in morbidly obese adolescents following bariatric surgery at Schneider Children's Medical Center of Israel (SCMCI).
- Trial name
- NCT02644174
- Testing
- Bariatric Surgery
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 1
Research Study in Japan to Compare Dasiglucagon With Glucagon in Treating Very Low Levels of Blood Sugar in Asian Adults With Type 1 Diabetes and Testing of Dasiglucagon for the Same Condition in Japanese Adolescents
This study will be looking to confirm the effect of dasiglucagon when compared with glucagon for treating very low sugar levels in Asian adults with T1D and the effect of dasiglucagon in Japanese adolescents with T1D.
- Trial name
- NCT06588504
- Testing
- Dasiglucagon, Glucagon
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Study to Test How New Long-acting Insulin (Insulin Icodec) Works in the Body of Children and Teenagers
Insulin icodec is a new medicine which is under development for use in humans and is not yet available at the pharmacy. It is being developed for the treatment of diabetes, a condition that causes high blood sugar levels.
- Trial name
- NCT05790681
- Testing
- Insulin icodec
- Where
- 21 sites in United States
- Volunteers
- 18 people
- Sponsor
- Novo Nordisk A/S
Severe Pediatric Obesity (BMI > 97° pc -According to Centers for Disease Control and Prevention BMI Charts-), Altered Liver Function Tests
Obalon in Children With Severe Obesity
The ongoing global rise in the prevalence of overweight and obesity among all ages and among all ethnic groups, figures into a real epidemic phenomenon.
- Conditions
- Severe Pediatric Obesity (BMI > 97° pc -According to Centers for Disease Control and Prevention BMI Charts-), Altered Liver Function Tests, Glycemic Intolerance
- Trial name
- Obalon (NCT02137330)
- Testing
- Swallowable Obalon® Gastric Balloon
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Friedreich Ataxia
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients
A drug repositioning effort provided evidence supporting the possible use of Etravirine, a drug approved for the treatment of HIV infections in patients starting from 2 years of age, as a treatment for FA.
- Trial name
- FAEST1 (NCT04273165)
- Testing
- Etravirine Tablets
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Unnecessary Procedures, Low Back Pain
Promoting Patient-Centered Counseling to Reduce Inappropriate Diagnostic Tests
In this study, the investigators will develop and evaluate a novel intervention using standardized patients (SPs) -- or actors playing the roles of patients -- to enhance physicians' patient-centered counseling skills regarding…
- Conditions
- Unnecessary Procedures, Low Back Pain, Osteoporosis, Headache
- Trial name
- NCT01808664
- Testing
- Standardized Patient Instructor Intervention, Control
- Volunteers
- 61 people
- Sponsor
- University of California, Davis
Li-Fraumeni Syndrome, Neoplasms
Clinical and Genetic Studies of Li-Fraumeni Syndrome
Background: Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk for some types of cancer. LFS may lead to cancer of the bone or connective tissue, breast, and brain.
- Conditions
- Li-Fraumeni Syndrome, Neoplasms, Tp53 Mutations
- Trial name
- NCT01443468
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Type 1 Diabetes
Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening
This study aims at quantifying the accuracy of a self-administered fingerstick based glucose tolerance test (GTT@Home) respect to the gold-standard in-clinic venous plasma measures during the oral glucose tolerance test (OGTT)…
- Trial name
- NCT07155252
- Testing
- GTT@Home
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Brain Injury Traumatic Mild
Using Routine Inflammatory and Metabolic Blood Tests (Bedside Included) to Predict Brain Injury in Children After Minor Head Trauma
Traumatic brain injury (TBI) poses significant strains on the paediatric population, for which the possible side effects of diagnostic imagistics could induce life-altering conditions.
- Trial name
- paeds_mTBI_Bio (NCT07397091)
- Where
- 7 sites in Romania
- Volunteers
- 800 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Diabetes Mellitus, Insulin-Dependent
Continuous Glucose Monitors for Children With Diabetes Mellitus
Good control of blood glucose levels is important in preventing complications from diabetes. This study assessed the accuracy and reliability of two FDA-approved continuous glucose monitors, the Continuous Glucose Monitoring…
- Trial name
- NCT00069537
- Testing
- The GlucoWatch® G2™ Biographer (GW2B), The Continuous Glucose Monitoring System (CGMS™)
- Where
- 6 sites in United States
- Volunteers
- 90 people
- Sponsor
- Jaeb Center for Health Research
Child Development
Strengthening Bangladeshi Babies Brains (SBBB)
This study aims to establish a sustainable programme whereby early childhood development activities are integrated into the routine activities of community clinics in rural Bangladesh for undernourished children by developing a…
- Trial name
- BUDHI/SBBB (NCT04093934)
- Testing
- Psychosocial stimulation
- Where
- Bangladesh
- Volunteers
- 480 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Familial Hypercholesterolemia
Cascade Genetic Testing of Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is a frequent genetic disorder (1/200) associated with an increased risk of early-onset myocardial infarction.
- Trial name
- CATCH (NCT04419090)
- Testing
- web-based centralized service and message
- Where
- Switzerland
- Volunteers
- 379 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Hypoglycemia
Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia
The purpose of this study is to compare the accuracies and the capillary and venous comparabilities of five different home glucose monitors; Optium Xceed, Contour Ts, Accu-chek Go, One Touch Select and Ez Smart in an adult…
- Trial name
- NCT01013402
- Testing
- Human insulin
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Gulhane School of Medicine
Obesity, Childhood, Nutrition Aspect of Cancer
Adaptive Implementation to Optimize Delivery of Obesity Prevention Practices in Early Care and Education Settings
"Together, We Inspire Smart Eating" (WISE) is an intervention that improves children's diets in ECE. WISE includes 4 key evidence-based practices (EBPs): (1) hands-on exposures to fruits and vegetables, (2) role modeling by…
- Trial name
- NCT05050539
- Testing
- Low Intensity, High Intensity
- Where
- United States
- Volunteers
- 1,613 people
- Sponsor
- University of Arkansas
Malnutrition in Children, Children Exposed to HIV
A Trial Testing a Two-way SMS Platform to Recognize and Prevent Wasting Among HIV-infected and HIV-exposed Uninfected Children in Kenya
The goal of this study is to test if a two-way text-message (SMS) maternally administered malnutrition monitoring system (MAMMS) that delivers infant and young child feeding (IYCF) education and supports caregivers in monitoring…
- Trial name
- MAMMS IYCF R33 (NCT06842732)
- Testing
- Maternal Administered Malnutrition Monitoring System - Infant and Young Child Feeding (MAMMS IYCF) intervention, Standard of Care (SOC)
- Where
- 2 sites in Kenya
- Volunteers
- 776 people, healthy volunteers welcome
- Sponsor
- University of Washington
Type 1 Diabetes
Fully Closed Loop At Home (FCL@Home)
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a…
- Trial name
- NCT06041971
- Testing
- AIDANET system
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Diabetes, Stroke
Testing the Developmental Origins Hypothesis
INTRODUCTION: CHIPS-Child is a parallel, ancillary study to the CHIPS randomized controlled trial (RCT). CHIPS is designed to determine whether 'less tight' control [target diastolic BP (dBP) 100mmHg] or 'tight' control [target…
- Conditions
- Diabetes, Stroke, Obesity
- Trial name
- CHIPS-Child (NCT01545492)
- Where
- 41 sites in United States, Australia and 6 more
- Volunteers
- 626 people
- Sponsor
- Children's & Women's Health Centre of British Columbia