Clinical trials: Metabolite
Healthy, Nervous System Disease
Functional and Metabolic Imaging Using Magnetic Resonance Imaging and Spectroscopy
Technical advances in magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have provided researchers with the opportunity to study changes of the central nervous system (CNS) and improve diagnosis and…
- Trial name
- NCT00001591
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Obesity, Childhood
Acetaminophen Dosing in Obese Adolescents
Although there are numerous studies investigating the pharmacokinetic properties of intravenous acetaminophen in infants and children with normal weight, there are none in the obese pediatric patient .
- Trial name
- NCT03192566
- Testing
- Tylenol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Healthy
Influence of Vitamin-B-complex on Cognitive Ability of Kindergarten Kids
Vitamin-B and Folic intake of Kindergarten kids in Germany is only 50-70% of the official recommendations. In studies with adults it has been found that for example providing people suffering from Alzheimer´s disease improved…
- Trial name
- SIMBA (NCT00811291)
- Testing
- Vitamine-B and Folic Acid Complex, calcium, calcium
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Attention-deficit/Hyperactivity Disorder
Gut Microbiome and Serum Metabolome Alterations in ADHD Patients
Host-microbe interactions play a key role in brain development and function and in the etiology of neurodevelopmental disorders.
- Trial name
- ADHD (NCT03447223)
- Where
- China
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Endometrial Carcinoma
Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain
This phase IV trial studies whether low dose aspirin can be used to lower inflammation and prevent endometrial cancer in postmenopausal women with changes in the endometrial tissue that are not related to thinning (non-atrophic…
- Trial name
- NCT07281547
- Testing
- Biospecimen Collection, Low-Dose Aspirin, Patient Observation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Inborn Errors of Metabolism, Epilepsy (Treatment Refractory)
Metabolites in Blood and Breath in Metabolic Conditions
In patients with inborn errors of metabolism (IEM) and in those requiring a ketogenic diet for the treatment of medical conditions, relevant biochemical analytes are routinely and regularly measured in venous or capillary blood…
- Trial name
- NCT07704606
- Testing
- Observational Study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
NMO Spectrum Disorder, Azathioprine Adverse Reaction
Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder
Background: The pathogenesis of NMOSD has been linked to the cytokines interleukins (IL) -6, NOD-, LRR-and pyrin domain-containing 3 (NLRP3) and IL-18 that contribute to development of inflammatory reactionsmay.
- Trial name
- NCT05896605
- Testing
- Azathioprine
- Where
- China
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
An Open-label, Single-dose, Non-randomized Study of IV 14C-labeled PER977 in Healthy Male Subjects
This is an open-label, single-dose, non-randomized study in healthy male subjects to characterize the mass balance, metabolic disposition, and identification of the metabolites and general metabolic pathways following…
- Trial name
- NCT02205905
- Testing
- 14C PER977
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Vitamin D Deficiency
Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children
The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and if it may have functional consequences on vitamin D activity.
- Trial name
- VitaD (NCT01050387)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Pancreatic Exocrine Insufficiency
The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)
DETECTION. The development of a metabolomic test to diagnose and quantify pancreatic exocrine insufficiency.
- Trial name
- DETECTION (NCT05980221)
- Testing
- Metabolomics, 13C MTGT
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
IgA Nephropathy
Correlation of Microbiome and Metabonomics With IgA Nephropathy
IgAN is the most prevalent primary glomerulonephritis in China, is characterized by the deposition of IgA1 (particularly, galactose-deficient IgA1) in the glomerular mesangium.
- Trial name
- NCT05190848
- Where
- 5 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Cow Milk Allergy, Food Allergy
Detection of Metabolite Biomarkers for the Early Diagnosis and Prognosis of Cow's Milk Allergy in Children
In this study, fecal and urine samples will be collected from children diagnosed with : IgE mediated cow's milk allergy, suspected of a cow's milk allergy, but with negative diagnosis IgE mediated food allergy other than cow's…
- Trial name
- NCT04249973
- Testing
- Collection of urine and feces
- Where
- 8 sites in Belgium
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Ghent
Polyethylene Glycols, Children, Only
Polyethylene Glycol Safety in Children
The primary objective is to measure levels of selected PEG 3350 components and metabolites in the blood and urine of children who are already taking PEG 3350 compared to children who are not taking PEG 3350.
- Trial name
- NCT05424757
- Testing
- PEG 3350
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Acute Pancreatitis, 2019 Novel Coronavirus Infection
Study and Analysis of Acute Pancreatitis Complicated With COVID-19
The goal of this observational study was to explore the complex relationship between changes in the intestinal microbiome and serum metabolites in patients with novel coronavirus infection and acute pancreatitis.
- Trial name
- NCT05722678
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yuansong Sun
Allergic Disorder, Food Hypersensitivity
Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age…
- Conditions
- Allergic Disorder, Food Hypersensitivity, Food Allergy in Children
- Trial name
- NCT05442658
- Testing
- Microbiota
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Children, Pain
Pharmacokinetics of Intravenous Metamizole in Children Less Than 6 Years Old
This study aims to assess the PK parameters of metamizole following a single IV administration of metamizole in children less than 6 years of age.
- Conditions
- Children, Pain, Surgery
- Trial name
- PPMS (NCT02660177)
- Testing
- Metamizole
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as…
- Conditions
- Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
- Trial name
- NCT07125001
- Testing
- Ataulfo mango
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Health
Effects of Coffee Consumption on Health Among Adults
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard…
- Trial name
- NCT03817944
- Testing
- Warm Water, Caffeinated Coffee, Decaffeinated Coffee
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhejiang University