Clinical trials: Methicillin-Resistant Staphylococcus Aureus
Staphylococcal Skin Infection, Abscess
Individualized vs. Household MRSA Decolonization
The purpose of this research study is to compare the effectiveness of commonly used decolonization treatments (application of mupirocin antibiotic ointment to the nose and bleach baths) when performed by individuals with a…
- Conditions
- Staphylococcal Skin Infection, Abscess, Furunculosis, Staphylococcus Aureus
- Trial name
- HOME2DS (NCT01814371)
- Testing
- 2% mupirocin ointment, Bleach Bath (dilute), Hygiene Protocol
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- Washington University School of Medicine
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community
The overall goal of this project is to elucidate the epidemiology of MRSA transmission in the community and test an intervention to prevent MRSA transmission in this setting.
- Trial name
- NCT00966446
- Testing
- Unsupervised Decolonization, Supervised Decolonization
- Where
- 4 sites in United States
- Volunteers
- 223 people
- Sponsor
- University of Pennsylvania
Methicillin-Resistant Staphylococcus Aureus, Cystic Fibrosis
Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)
This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy.
- Trial name
- TRI-STAR (NCT02684422)
- Testing
- Intervention N/A. Observational study
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Bacterial Resistance, Methicillin-Sensitive Staphylococcus Aureus Infection
Antistaphylococcal Betalactam and Emergence of Resistance
Antistaphylococcal penicillins are recommanded as first-line agent in methicillin-suceptible Staphylococcus aureus bacteraemia. Several studies in progress are investigating the efficacy and safety of cefazolin compared with…
- Trial name
- CePasR (NCT05939479)
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Central Hospital, Nancy, France
Methicillin Resistant Staphylococcus Aureus Skin Infections
A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection
This clinical trial tests the hypotheses that 1) body decolonization of patients with recurrent community-associated (CA) MRSA infections and their household members and 2) environmental decolonization of the patients' households…
- Trial name
- PRIMO (NCT00560599)
- Testing
- mupirocin and chlorhexidine, household cleaning and disinfection, mupirocin, chlorhexidine, & household cleaning/disinfection
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- loren g miller
Cirrhosis, Bacterial Infections
International Surveillance of Antimicrobial Resistance in Cirrhosis-Related Infections
What is this study about? This study tracks antibiotic resistance in patients with cirrhosis who develop bacterial infections. Cirrhosis is a condition where the liver is severely scarred, and people with cirrhosis are at high…
- Conditions
- Cirrhosis, Bacterial Infections, Multidrug Resistance
- Trial name
- NCT06634940
- Where
- Argentina
- Volunteers
- 1,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Staphylococcus Aureus Bacteremia
Staphylococcus Aureus Network Adaptive Platform Trial
The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with…
- Trial name
- SNAP (NCT05137119)
- Testing
- Cefazolin, Penicillin, Clindamycin
- Where
- 161 sites in United States, Australia and 11 more
- Volunteers
- 8,000 people
- Sponsor
- University of Melbourne
Nasal Colonization With MRSA Bacteria
Microbiological Characterization and Nasal Carriage Rates of Methicillin Resistant Staphylococcus Aureus (MRSA) in Vancouver Downtown Eastside
We plan to compare data from 300 nasal swab in Vancouver's Downtown Eastside taken in 2001 to data obtained in 2005. The nasal carriage rate of MRSA and the specific characteristic of each MRSA found will be analyzed.
- Trial name
- NCT00247871
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of British Columbia
Infections, Bacterial
Gram-negative Bacilli and MRSA Screening in ICU in China
Carbapenem-resistant Gram-negative bacilli [Carbapenem-resistant Acinetobacter baumannii (CRAB), Carbapenem-resistant Klebsiella pneumoniae (CRKP), and Carbapenem-resistant Pseudomonas aeruginosa (CRPsA) ] and…
- Trial name
- NCT04310722
- Testing
- None intervention. This is an observational study.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
NAsal MEthicillin-resistant Staphylococcus
NAsal MEthicillin-resistant Staphylococcus (NAMES): a Prospective Study to Assess the Impact of Antibiotic Therapy on Nasal Colonization with Methicillin-resistant Staphylococcus Aureus (MRSA) Inhospitalized Children
Antimicrobial resistance (AMR) is recognized as one of the major threats to global health [1], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs.
- Trial name
- NAMES (NCT06872099)
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Staphylococcal Infection, Abscess
Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections
The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).
- Conditions
- Staphylococcal Infection, Abscess, Staphylococcal Skin Infection, Folliculitis
- Trial name
- NCT00352612
- Testing
- clindamycin, cephalexin
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aaron Chen
Staphylococcus Aureus
A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA
Background: Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen of the 21st century whose incidence as a cause of local and invasive infections has significantly increased, especially…
- Trial name
- NCT00532324
- Testing
- CA-MRSA Decolonization
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Orthopedic Procedures, Methicillin-resistant Staphylococcus Aureus
Treatment of Patients Colonized With Methicillin-Resistant Staphylococcus Aureus Prior to Bone and Joint Surgery
The investigators anticipate that utilization of retapamulin preoperatively will eliminate MRSA colonization among patients who are colonized in their nares.
- Trial name
- TOPS-MRSA (NCT00903279)
- Testing
- Altabax (retapamulin)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bay Pines VA Healthcare System
Cystic Fibrosis
STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)
To evaluate the micro-biologic efficacy and safety of a streamlined treatment for early onset methicillin-resistant staphylococcus aureus (MRSA) in patients with cystic fibrosis.
- Trial name
- STAR-TER (NCT03489629)
- Testing
- Trimethoprim Sulfamethoxazole (TMP/SMX), Minocycline, Mupirocin
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of North Carolina, Chapel Hill
Skin Infections, Bacterial
Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA
The purpose of this study is to provide further evidence of the clinical and bacteriological efficacy of retapamulin in the treatment of subjects with SITL or impetigo due to MRSA.
- Trial name
- NCT00852540
- Testing
- Retpamulin Ointment, 1%, Linezolid
- Where
- 53 sites in United States
- Volunteers
- 410 people
- Sponsor
- Stiefel, a GSK Company
Methicillin-Resistant Staphylococcus Aureus
Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy
Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with…
- Trial name
- NCT02363166
- Testing
- Acute Abscess Group
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- University of Florida
Community-acquired Methicillin-resistant Staphylococcus Aureus Infection
New Mexico Honey Wound Treatment Research Study
In a time of emerging bacteria that are resistant to antibiotics, honey offers an alternative that has potential to reduce the heavy reliance on pharmaceutical antibiotics.
- Trial name
- NCT01748318
- Testing
- New Mexico Honey, Bactrim DS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- R. Stephen Rankin, M.D.
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Staphylococcus Aureus, Bacteremia
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens.
- Trial name
- NCT01352936
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Taipei Medical University WanFang Hospital