Clinical trials: Methotrexate
Methotrexate Toxicity
Evaluation of High Dose Methotrexate Toxicity
This study aims to: 1. Evaluation of high dose methotrexate related toxicities among children admitted to Sohag Oncology Centre. 2. Role of methotrexate blood level in prediction of high dose methotrexate related toxicities. 3.
- Trial name
- NCT06123403
- Testing
- blood methotrexate level and Cystatin C level
- Volunteers
- 100 people
- Sponsor
- Sohag University
Methotrexate Adverse Reaction, Oral Mucositis
Stratification of Oral Ulcers in Rheumatoid Arthritis Patients Kept on Methotrexate
This study included rheumatoid arthritis patients receiving Methotrexate as monotherapy. All eligible patients were subjected to thorough clinical examination and full history to identify oral events.
- Trial name
- NCT04540250
- Testing
- questionnaire
- Volunteers
- 804 people
- Sponsor
- Beni-Suef University
Takayasu Arteritis, Methotrexate
Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients
Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy.
- Conditions
- Takayasu Arteritis, Methotrexate, Inhibition, Treatment
- Trial name
- NCT04299971
- Testing
- Methotrexate Tablets, Tofacitinib tablet
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Shanghai Zhongshan Hospital
Inflammatory Bowel Diseases, Liver Fibroses
Dose Effect Relationship of MTX and IBD
Currently there are no guidelines for monitoring hepatic fibrosis associated with long term MTX use. Routine liver biopsies are not being done as a part of surveillance due to potential complications like bleeding and…
- Conditions
- Inflammatory Bowel Diseases, Liver Fibroses, Methotrexate
- Trial name
- NCT03531593
- Testing
- Ultrasound Elastography
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's Mercy Hospital Kansas City
Methotrexate Adverse Reaction
Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies
The pharmacokinetics of MTX were assessed with regards to the relevance of several different patient specific factors in 291 pediatric patients, who were administered with high dose of MTX.
- Trial name
- HDMTX (NCT02011022)
- Testing
- 3g MTX, 5g MTX
- Where
- China
- Volunteers
- 291 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Methotrexate Induced Nephrotoxicity
Prevention of Methotrexate Induced Nephrotoxicity and Prolonged Drug Elimination Time With 12 Hours Prehydration
Infusions with high-dose methotrexate 5 g/m2 or 8 g/m2 are used to treat children with acute lymphoblastic leukemia (ALL), non-Hodgkin's lymphoma, medulloblastoma and ependymoma.
- Trial name
- NCT00570817
- Testing
- 12 hours of prehydration
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- University of Aarhus