Clinical trials: Methylene Blue
Diabetic Foot Ulcers, Diabetic Wound
The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
The aim of this study is to evaluate the chance of non-healing diabetic foot ulcers repair by improving the condition of lack of oxygen or hypoxia in the wound area caused by diabetes using methylene blue along with the use of…
- Trial name
- NCT05850611
- Testing
- Methylene Blue, Milk (control), Methylene Blue and Platelet-Rich Plasma-Fibrin Glue
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Impact of Intraoperative Spraying Methylene Blue In Thyroidectomy
Impact of Intraoperative Spraying Methylene Blue In Thyroidectomy
Impact of Intraoperative Spraying methylene blue In thyroidectomy
- Trial name
- methylene (NCT05367869)
- Testing
- Impact of Intraoperative Spraying Methylene Blue In Thyroidectomy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qena Oncology Center
Septic Shock, Methylene Blue
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the…
- Conditions
- Septic Shock, Methylene Blue, Sepsis
- Trial name
- NCT06481410
- Testing
- Methylene Blue Intervention Group, Normal Saline Control Group
- Where
- China
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acquired Methaemoglobinaemia
MEthylene Blue In Patients With Acquired Methemoglobinemia
This is an open label, uncontrolled, Phase 4 study including 10 patients who present in hospital/urgent care setting with acquired methemoglobinemia.
- Trial name
- MEBIPAM (NCT03395223)
- Testing
- Methylene Blue
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Provepharm SAS
Chromogenic Extrinsic Tooth Stains
Photodynamic Therapy for Preventing Recurrent Chromogenic Stains on Deciduous Teeth
Chromogenic extrinsic stains are common in children and frequently recur following conventional prophylaxis. Antimicrobial photodynamic therapy (aPDT) using methylene blue activated by red light has demonstrated antimicrobial…
- Trial name
- NCT07736339
- Testing
- Antimicrobial Photodynamic Therapy, Conventional Prophylaxis
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Methemoglobinemia, Acquired, Methemoglobinemia
Acquired Methemoglobinemia Observational Registry
This prospective, observational registry aims to collect real-world data regarding the safety and efficacy of ProvayBlue® (methylene blue 0.5%) used according to normal standard of care for the treatment of acquired…
- Trial name
- metHb (NCT03542760)
- Testing
- Methylene Blue
- Where
- 32 sites in United States
- Volunteers
- 24 people
- Sponsor
- Hospital Quality Foundation
COVID-19, Corona Virus Infection
Nasal Photodisinfection COVID-19 Proof of Concept Study
The study proposes to test photodisinfection (PDF) on SARS-CoV-2 in the nose. The study will use Health Canada approved Steriwave™ Nasal Decolonization (ND) in he nostril of patients infected with SARS-CoV-2.
- Conditions
- COVID-19, Corona Virus Infection, SARS-CoV 2
- Trial name
- NCT04615936
- Testing
- Methylene-Blue Photodisinfection
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sunnybrook Health Sciences Centre
Oral Mucositis
Oral Mucositis and Laser Therapy Associated With Photodynamic Therapy
The aim of the study was to evaluate the therapeutic action through the diameter of the lesion, of low level laser (LLL) associated to photodynamic therapy (PDT) in oral mucositis (OM) lesions, in young patients.
- Trial name
- OMLTPT (NCT02555501)
- Testing
- PDT + Low level laser, Low level laser
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Ceuma
Sentinel Lymph Node, Breast Cancer
Application of Surgical Navigation System in Sentinel Lymph Node of Breast Cancer Research
The purpose of this study is to compare the sentinel lymph node (SLN) detection rate of early breast cancer patients between using Indocyanine green (ICG) and Methylene blue with a novel surgical navigation system.
- Trial name
- NCT02084784
- Testing
- Indocyanine green, methylene blue
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese Academy of Sciences
Malaria
Efficacy of Methylene Blue for Malaria Treatment in Adults of Burkina Faso: Proof of Principle Study in Semi-Immune Adults of Burkina Faso in the Frame of the A8 Project of the SFB 544
Design: Single-centre, controlled study in adults with uncomplicated falciparum malaria in the Nouna Health District, north-western Burkina Faso Phase: Phase II Objectives: The primary objective of this trial is to study the…
- Trial name
- NCT00917202
- Testing
- Methylenblue
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
Foreign Bodies, Ultrasound
Foreign Body Removal With the Assistance of Ultrasound Guidance and Methylene Blue Staining in Children
Soft-tissue foreign bodies (FB) are very commonly observed in pediatric emergency departments. Some are metallic and can be diagnosed easily via X-ray radiography, whereas others are radiolucent and are hence less easily…
- Trial name
- NCT05085509
- Testing
- US guidance and MB staining
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yuxi Su
Septic Shock, Refractory Shock
What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin
The ICU mortality rate of patients with septic shock was still high upto 54.1%.In first 6 hours of resuscitation, the goals of resuscitation in sepsis shock after adequate fluid resuscitation is MAP ≥65 mmHg.
- Trial name
- NCT03038503
- Testing
- Methylene Blue, Terlipressin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Malaria, Falciparum
Methylene Blue Against Falciparum Malaria in Burkina Faso
Safety of artesunate-amodiaquine combined with methylene blue or primaquine for falciparum malaria treatment in African children: A randomised controlled trial Elimination has become the goal of malaria programmes in an…
- Trial name
- BlueACTn (NCT02851108)
- Testing
- Methylene Blue, Primaquine
- Where
- Burkina Faso
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Verruca Vulgaris
Photodynamic Therapy in Treatment of Verrucae
To assess the efficacy (clinically and dermoscopically) and safety of photodynamic therapy using intralesional injection of 4% methylene blue solution as a photosensitizer with IPL versus IPL only in treatment of warts.
- Trial name
- NCT04620785
- Testing
- methylene blue / IPL, IPL, saline
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Malaria
Safety and Efficacy of Methylene Blue Combined With Artesunate or Amodiaquine for Malaria Treatment in Children of Burkina Faso: a Pilot Study
The primary objective of this trial is to study the safety of the combination methylene blue (MB)-artesunate (AS) and MB-amodiaquine (AQ) in treating malaria among children compared to the safety of an AS-AQ regimen.
- Trial name
- NCT00354380
- Testing
- Methylene blue, Artesunate, Amodiaquine
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
Hemorrhoids, Anal Fissure and Fistula
Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia
Study Description: The goal of this clinical trial is to compare the duration of postoperative pain relief achieved with two different approaches to pudendal nerve block in patients undergoing elective perianal surgery.
- Conditions
- Hemorrhoids, Anal Fissure and Fistula, Perianal Abscess, Perianal Fistula
- Trial name
- NCT05990569
- Testing
- Ultrasound guided Pudendal nerve block
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nepal Mediciti Hospital
Bone Diseases
Use of a Radiopaque Localizer Grid and Methylene Blue Staining as an Aid to Reduce Radiation Exposure
Localization of small femur lesions for resection can be challenging and may be associated with the need for significant fluoroscopic imaging and tissue dissection.
- Trial name
- NCT02969005
- Testing
- surgical treatment
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Malaria
Phase 2 Efficacy Study of Primaquine and Methylene Blue
The purpose of this study is to determine the most efficacious transmission blocking drug regimen for seasonal malaria chemoprophylaxis in Mali.
- Trial name
- NCT02831023
- Testing
- Sulphadoxine-pyrimethamine, 0.25 mg/kg primaquine, Dihydroartemisinin-piperaquine
- Where
- Mali
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Uncomplicated Falciparum Malaria
Efficacy and Safety of Artesunate-amodiaquine-methylene for Malaria Treatment in Children
Title: Efficacy and safety of artesunate-amodiaquine combined with methylene blue for falciparum malaria treatment in African children: randomised controlled trial.
- Trial name
- NCT01407887
- Testing
- artesunate (AS) - amodiaquine (AQ) - methylene blue (MB)
- Where
- Burkina Faso
- Volunteers
- 180 people
- Sponsor
- Heidelberg University