Clinical trials: Microvascular Circulation
Breast Reconstruction, Skin Perfusion
Microcirculation of the Abdominal Skin After Deep Inferior Epigastric Artery Perforator Flap Procedure
The purpose of this study was to perform a quantitative perfusion study of the undermined abdominal skin in deep inferior epigastric artery perforator flap breast reconstruction patients in order to obtain more knowledge on…
- Trial name
- NCT02481284
- Testing
- Laser Doppler perfusion imaging
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Child, Only, Obesity
Microvascular Reactivity in Prepubertal Children
This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.
- Conditions
- Child, Only, Obesity, Endothelial Dysfunction
- Trial name
- MicroChild (NCT03171441)
- Testing
- nailfold videocapillaroscopy, inflammatory biomarkers
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Circulatory; Change, Microcirculation
Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis
The incidence of anastomotic leaks after gastroesophageal anastomosis after thoracolaparoscopic cancer esophagus surgery is high at the Oslo University Hospital.
- Trial name
- NCT03724162
- Where
- 2 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Sickle Cell Disease
Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease
This study will determine if administration of sodium nitrite is safe and can improve small vessel blood flow and tissue oxygenation when given as an additional treatment in patients with acute vaso-occlusive crisis (pain crisis)…
- Trial name
- NCT01033227
- Testing
- sodium nitrite injection, usp
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Los Angeles
Diabetes Mellitus
Assessing Diabetic Foot Ulcer Microcirculation With High-frequency Contrast Enhanced Ultrasound
The objective of this observational study is to investigate and validate the utility of high-frame-rate ultrasound imaging technology for dynamic observation of the blood perfusion process at the site of ulcer wounds in…
- Trial name
- NCT06309082
- Testing
- Amputation, Debridement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Congenital Heart Disease
Evaluation of the Microcirculation During the Corrective Surgery of Congenital Heart Defects in Children
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
- Trial name
- NCT03144258
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Sepsis
Glycocalyx and Microcirculation in Sepsis
The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis.
- Trial name
- NCT03960307
- Testing
- Microcirculation and Glycocalyx assessment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Diabetes Mellitus, Healthy
Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects
Nitric oxide (NO) is a soluble gas, continuously synthesized by the endothelium, that contributes importantly to vasodilator tone of the coronary and systemic circulations by activating guanylyl cyclase in vascular smooth muscle…
- Conditions
- Diabetes Mellitus, Healthy, Hypercholesterolemia, Hypertension
- Trial name
- NCT00001963
- Testing
- hemoglobin-transported nitric oxide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus
New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young subjects.
- Conditions
- Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus, Anomalous Coronary Artery Course, Anomalous Coronary Artery with Aortic Origin and Course Between the Great Arteries
- Trial name
- NECESSARY (NCT05159791)
- Testing
- Invasive coronary blood flow assessment and simulations and fluid dynamic patient specific simulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Policlinico S. Donato
Liver Cirrhosis, Early Allograft Dysfunction
Intraoperative Assessment of Microcirculatory Function Using Vascular Occlusion Test During Liver Transplantation
Early allograft dysfunction (EAD) remains one of the most important complications following orthotopic liver transplantation (OLT).
- Trial name
- NCT07658794
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Ippokrateio General Hospital of Thessaloniki
Severe Sepsis or Septic Shock in Pediatric Intensive Care Unit
Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock
Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign ".
- Trial name
- PRECISE (NCT04027699)
- Testing
- Mini-bolus
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myopia
Effects of 650nm Low Energy Light on Human Retina and Choroid Microcirculation
This project is a single-center, prospective, self-controlled clinical study. It intends to select patients with simple medium and low degree myopia as subjects, and apply 650nm low-energy red light irradiation to the retina to…
- Trial name
- NCT04604405
- Testing
- photobiomodulation
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Central South University
Pulmonary Arterial Hypertension
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a rare, severe disease, characterized by a progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure and premature death.
- Trial name
- NCT01520493
- Testing
- Submaximal exercises
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Child Development
Immediate Effect of Kangaroo Position in Electromyographic Activity and Microcirculation of Newborn Preterm
Introdution: The Kangaroo Mother Care is a perinatal care model for preterm and low weight newborn. The Kangaroo Position is the main feature of this method.
- Trial name
- NCT02849665
- Testing
- Kangaroo Position
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Cardiovascular Diseases, Heart Diseases
Racial Differences in the Coronary Microcirculation
To study mechanisms of excess coronary ischemia secondary to alterations in autoregulation and arteriolar vasoreactivity in Black Americans with hypertension, varying degree of left ventricular hypertrophy, and angiographically…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005373
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling…
- Trial name
- DREAM² (NCT02909283)
- Testing
- Physical exams and blood analyzes
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Imagine Institute
Cleft Palate, Cleft Lip and Palate
Assessment of the Influence of Cleft Repair on Microcirculation of the Palate
Investigators aim to evaluate the influence of cleft surgery on the tissue microcirculation of the palate with a non-invasive measurement.
- Trial name
- NCT03877666
- Where
- Switzerland
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health