Clinical trials: Middle Ear Disease
Cholesteatoma, Middle Ear, Cholesteatoma, Residual
Comparison of Outcomes of Microscopic Mastoidectomy With and Without Check Endoscopy
Cholesteatoma is a serious otological condition and a major challenge for otolaryngologists worldwide. If left undetected and untreated, it can erode the surrounding bone, ear ossicles, facial nerve canal, bony labyrinth or…
- Trial name
- NCT07896200
- Testing
- Microscopic Mastoidectomy, Check Endoscopy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Emergence Agitation, Emergence Delirium, Anesthesia
Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.
This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general…
- Conditions
- Emergence Agitation, Emergence Delirium, Anesthesia, Emergence From Anesthesia, Emergence Delirium
- Trial name
- NCT07435675
- Testing
- ultrasound-guided greater auricular nerve block (GANB)
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Cleft Palate, Tube Disorders Eustachian
Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate
Elevation of the soft palate (the soft part of the roof of the mouth) during swallowing helps the Eustachian tube to open and keep the ear healthy.
- Conditions
- Cleft Palate, Tube Disorders Eustachian, Velopharyngeal Incompetence Due to Cleft Palate, Velopharyngeal Insufficiency
- Trial name
- NCT03868891
- Testing
- EMST150
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Noel Jabbour
Otitis Media, Middle Ear Effusion
Clinical Study of Solo Tympanostomy Tube Device (TTD)
This is a multi-centre, single arm study to evaluate the placement of tympanostomy tubes with the AventaMed Solo Tympanostomy Tube Device (TTD)
- Trial name
- NCT02957578
- Testing
- Solo TTD
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- PneuMum (NCT00714064)
- Testing
- 23vPPV, dTpa (Pneumovax, Boostrix)
- Where
- Australia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Otitis Media With Effusion
OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
The purpose of this study is to confirm the effectiveness, safety and tolerability of OTO-201 in the treatment of pediatric subjects with bilateral middle ear effusion who require tympanostomy tube placement.
- Trial name
- NCT01949142
- Testing
- OTO-201
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Otonomy, Inc.
Cleft Palate
Middle Ear Pressure Disregulation in Cleft Palate Patients
The investigators know that middle-ear disease is very common in infants with cleft palate and causes hearing loss that can last into childhood.
- Trial name
- NCT00423072
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Pittsburgh
Ear Barotrauma, Middle Ear Disease
Effect of Rate (Slope) of Compression on the Incidence of Symptomatic ETD and MEB: a Phase III Prospective Study.
Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are common reported complications during hyperbaric oxygen treatment.
- Conditions
- Ear Barotrauma, Middle Ear Disease, Ear Diseases, Pressure Injury
- Trial name
- NCT04804098
- Testing
- Compression Profile/Schedule: 15 minute Non-Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw), Compression Profile/Schedule: 15 minute Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)
- Where
- United States
- Volunteers
- 1,553 people
- Sponsor
- Northwell Health
Otic Barotrauma, Pressure Injury
Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System
This validation study investigates the diagnostic precision and accuracy when grading otic barotrauma using two alternative gradings systems including the TEED and the OGS grading systems.
- Conditions
- Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis
- Trial name
- OGS (NCT04726306)
- Testing
- Otic Barotrauma Grading System
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Type 2 Inflammatory Disorders
Compassionate Use or Expanded Access of Dupilumab
Provide Compassionate Use or Expanded Access of Dupilumab
- Trial name
- NCT04776694
- Testing
- Dupilumab
- Sponsor
- Regeneron Pharmaceuticals
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Secretory Otitis Media, Acute Otitis Media
The Effect of Early Non-Surgical Treatment of Children With Middle Ear Effusion on the Hearing
Secretory otitis media (SOM) or middle ear effusion is a common finding after acute otitis media (AOM). It is usually associated with 5-15 deci Bells hearing loss.
- Trial name
- NCT02549612
- Testing
- Moniri Otovent
- Volunteers
- 80 people
- Sponsor
- Vastra Gotaland Region
Middle Ear Cholesteatoma
Associations of Pre- and Intraoperative Endoscopic Findings of Middle Ear Status in Cholesteatoma
The aim of this study is to assess the accuracy of preoperative HRCT of the temporal bone combined with the preoperative audiologic assessment compared with the intraoperative endoscopic middle ear finding.
- Trial name
- NCT04672187
- Where
- Thailand
- Volunteers
- 41 people
- Sponsor
- Prince of Songkla University
Otitis Media, Otitis Media With Effusion
Coherent Optical Detection of Middle Ear Disease
The purpose of this project is to see if optical coherence tomography (OCT), a new technology acting as an ultrasound for the ear, facilitates accurately diagnosing acute otitis media (AOM) and otitis media with effusion (OME) in…
- Conditions
- Otitis Media, Otitis Media With Effusion, Otitis Media Acute
- Trial name
- OCTII (NCT05353569)
- Testing
- OCT Device(s)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- Medical College of Wisconsin
Otitis Media, Otitis Media Chronic
SWIR Otoscopy Study
The aim of this study is to provide preliminary data to support future studies to demonstrate that the short wave infrared (SWIR) otoscope is a better diagnostic tool than a white light otoscope for diagnosing middle ear…
- Conditions
- Otitis Media, Otitis Media Chronic, Otitis Media Effusion
- Trial name
- NCT06944795
- Testing
- SWIR device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Deaf, Hard of Hearing
Effectiveness of Integrative Therapy on Psychological Hardiness Among Hard-of-Hearing Female Students
The goal of this clinical trial (quasi-experimental study) is to learn whether an integrative therapeutic program can enhance psychological hardiness among hard-of-hearing (HOH) female students in Saudi Arabia (Al-Ahsa…
- Conditions
- Deaf, Hard of Hearing, Hearing Disability
- Trial name
- Integrative (NCT07514468)
- Testing
- Integrative Therapeutic Program
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal University
Eustachian Tube Dysfunction
Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction
The aim of this study is to determine which of the many Eustachian tube function tests (or combination of tests) is most helpful in finding out what is causing ear problems in children and adult patients with middle-ear diseases…
- Trial name
- NCT01974726
- Testing
- ET Stress test, Sonotubometry, Forced Response Test (FRT)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh