Clinical trials: Mitral Valve Repair
Mitral Valve Insufficiency
The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children
The main problem in mitral valve repair surgery in children is the high number of postoperative residual lesions (49% of the total cases).
- Trial name
- NCT04518709
- Testing
- Posterior Mitral Annulus Elevation Technique, Conventional Mitral Valve Repair
- Volunteers
- 58 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅱ (NCT07007143)
- Testing
- Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel
- Where
- China
- Volunteers
- 1,032 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Mitral Valve Repair
Safety and Efficacy Study of a New Device for Making Neochordae in Mitral Valve Repair
Mitral prolapse is a common cardiac disease whose patients are at higher risk for serious complications. Mitral valve (MV) repair offers several important advantages compared with valve replacement and it achieves excellent…
- Trial name
- NCT01811537
- Testing
- Artificial Chordae
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Mitral Regurgitation (MR), Pediatric Cardiac Surgery
A Prospective Multicenter Cohort Study on Surgical Treatment Strategies for Pediatric Mitral Regurgitation
This prospective, multicenter cohort study aims to evaluate the outcomes of surgical repair for pediatric mitral regurgitation (MR) in China.
- Trial name
- NCT07284212
- Testing
- conventional mitral valve repair, standardized mitral valve repair
- Where
- China
- Volunteers
- 427 people
- Sponsor
- China National Center for Cardiovascular Diseases
Mitral Regurgitation
Edge-To-Edge Technique Used as a Bailout in Case of Sub-Optimal Mitral Repair: Very Long-Term Results
The absence of residual mitral regurgitation (MR) after mitral valve repair is of paramount importance for the long term durability of the valve repair.
- Trial name
- NCT05733988
- Testing
- Bailout edge to edge
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Michele De Bonis
Mitral Stenosis
Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
- Trial name
- NCT06067815
- Volunteers
- 30 people
- Sponsor
- Assiut University
Mitral Regurgitation Functional
Percutaneous Mitral Valve Repair in Cardiogenic Shock: Mitra-Shock Study
Cardiogenic shock (CS) is a medical emergency and a frequent cause of death. CS can be complicated and/or precipitated by mitral regurgitation (MR).
- Trial name
- MSS (NCT04399499)
- Testing
- MitraClip implantation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Mitral Valve Reconstruction
Clinical Comparative Analysis of Bretschneider and St. Thomas Cardioplegia Solution in Case of Mitral Valve Repair Via Anterolateral Right Thoracotomy
Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy is done in cardioplegia with a cardioplegic solution, either HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St.
- Trial name
- NCT03818113
- Testing
- cardioplegia with HTK-Bretschneider cardioplegic solution, cardioplegia with St. Thomas cardioplegic solution
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Disease, Mitral Valve Insufficiency
Should we Repair Ischemic Mitral Regurgitation?
The purpose of this study is to assess whether adding mitral valve repair to coronary artery bypass grafting improves outcome in patients with ischemic mitral regurgitation.
- Trial name
- NCT00443365
- Testing
- Mitral valve repair
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
Mitral Regurgitation
Comparison of Transcatheter Edge-to-edge Repair Using Echo Only with Echo Combined with X Ray for Mitral Regurgitation (ECHO-CLIP)
Mitral regurgitation (MR) is a common valvular heart disease in the elderly population, frequently associated with poor prognosis if not treated.
- Trial name
- NCT06684171
- Testing
- Echocardiographic guidance, Fluoroscopic guidance
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Pan Xiangbin
Mitral Regurgitation
Change in LVEF Following Transcatheter Mitral Edge-To-Edge Repair
Little is known regarding the impact of transcatheter mitral valve edge-to-edge repair (TEER) on the acute changes in left ventricular ejection fraction (LVEF) and the effect of an acute reduction in LVEF, the so-called…
- Trial name
- MITRA-EF (NCT05311163)
- Testing
- MitraClip
- Where
- Israel
- Volunteers
- 4,000 people
- Sponsor
- Rabin Medical Center
Mitral Regurgitation
The Papillary Muscle Approximation Provide Stability of Mitral Valve Repair for Ischemic Mitral Regurgitation
Recent publications show that an adjunctive subvalvular repair during mitral annuloplasty for secondary mitral regurgitation effective in preventing recurrent regurgitation.
- Trial name
- PMA (NCT03038204)
- Testing
- The papillary muscle approximation
- Volunteers
- 100 people
- Sponsor
- The Federal Centre of Cardiovascular Surgery, Russia
Mitral Valve Prolapse
The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
Multicentre, double-armed, randomized controlled trial designed to compare mitral valve leaflet resection versus leaflet preservation with regards to the development of functional mitral stenosis following surgical repair of…
- Trial name
- CAMRA (NCT02552771)
- Testing
- Mitral repair with leaflet preservation, Mitral repair with leaflet resection
- Where
- 6 sites in Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Cardiac Valve Disease
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
MANTRA is a prospective, multiple-arm, multi-center, global, post-market clinical follow-up study. The main objective is to monitor ongoing safety and performance of the CORCYM devices and accessories used for aortic, mitral and…
- Trial name
- MANTRA (NCT05002543)
- Where
- 52 sites in United States, Austria and 11 more
- Volunteers
- 2,150 people
- Sponsor
- Corcym S.r.l
Mitral Regurgitation
A Pan-Canadian, Retrospective Evaluation of MitraClip Safety and Efficacy
The PREMISE Registry is a retrospective, observational study that will evaluate the efficacy and safety of the MitraClip in real-world Canadian practice.
- Trial name
- PREMISE (NCT03592043)
- Testing
- MitraClip
- Where
- Canada
- Volunteers
- 1,191 people
- Sponsor
- Population Health Research Institute
Mitral Regurgitation
Outcome Registry and Assessment of New Edge-to-Edge Repair
The goal of this observational study is to learn about the long-term effects of Edge-tot-edge repair of all the patients of AmsterdamUMC, to treat their Mitral regurgitation (MR).
- Trial name
- ORANGE-TEER (NCT07108907)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Abby Geerlings
Mitral Valve Insufficiency, Heart Valve Diseases
NeoChord TACT Post-Market Surveillance Registry
To monitor the long-term performance of the CE Marked NeoChord Artificial Chordae Delivery System
- Conditions
- Mitral Valve Insufficiency, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT01784055
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 126 people
- Sponsor
- NeoChord
Mitral Valve Posterior Leaflet Prolapse
Triangular Exclusion Technique in Isolated Posterior Mitral Valve Leaflet Prolapse for Mitral Valve Repair
The goal of this clinical trial is to learn if surgical method done to repair one of the heart valve called mitral valve disease during open heart surgery The main questions aims to answer is: Does this method is safe and…
- Trial name
- NCT06778369
- Testing
- traingular exclusion technique in mitral valve repair
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Zagazig University
Congenital Mitral Insufficiency
Study of Innovative Drug Strategies in Improving Left Ventricular Function After Mitral Repair
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients after mitral repair.
- Trial name
- NCT06039592
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 164 people
- Sponsor
- China National Center for Cardiovascular Diseases
Mitral Regurgitation (MR)
Mitral Valve Repair With the Chord-X System: A Long Term Evaluation
The goal of this clinical trial is to strengthen the evidence available for the Chord-X System by collecting follow-up data from patients who underwent Chord-X implant and to evaluate the long-term safety and performance data…
- Trial name
- METRIX (NCT07413926)
- Testing
- Chord-X system implant
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 110 people
- Sponsor
- Artivion Inc.