Clinical trials: Model Informed Precision Dosing
Amoxicillin-clavulanate, Piperacillin-tazobactam
Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children
The overall objective of this study is to investigate the impact of early model-informed precision dosing (MIPD) on target attainment of three beta-lactam antibiotics (amoxicillin-clavulanic acid, piperacillin-tazobactam and…
- Conditions
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- MOMENTUM (NCT06929702)
- Testing
- Beta-lactam antibiotic, Beta-lactam model-informed precision dosing
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Pharmacokinetics, Area Under Curve
Model Informed preciSion doSIng tO iNdividualise and Optimize Pharmacotherapeutic Treatment
This is a prospective observational study of MIPD in clinical practice for paediatric kidney transplant patients using tacrolimus and mycophenolic acid in Radboudumc.
- Conditions
- Pharmacokinetics, Area Under Curve, Tacrolimus, Immunosuppressive Agents
- Trial name
- MISSION (NCT06095895)
- Testing
- venipuncture
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Vancomycin
Precision Dosing of Vancomycin in Critically Ill Children
The overall objective of this project is to investigate the large-scale utility of MIPD of vancomycin at point-of-care in ICU children.
- Trial name
- BENEFICIAL (NCT04666948)
- Testing
- vancomycin model-informed precision dosing, Vancomycin
- Where
- 7 sites in Belgium
- Volunteers
- 314 people
- Sponsor
- University Hospital, Ghent
Patent Ductus Arteriosus, Preterm
Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT
Newborns born early are at risk for a serious health problem called patent ductus arteriosus (PDA). PDA is a passageway between heart and lung that can cause life-threatening complications such as bleeding in the brain or even…
- Trial name
- MIPD-PDA (NCT07143201)
- Testing
- Standard Dose - Ibuprofen oral suspension, Precision Dose - Ibuprofen oral suspension
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Hamilton Health Sciences Corporation
Bone Marrow Transplantation, AML
Model-Informed Precision Dosing on Cyclosporine Therapy in Hematopoietic Stem Cell Transplant Recipients
The purpose of this study is to develop a new tool that helps doctors choose the right cyclosporine dose for patients undergoing bone marrow transplantation.
- Trial name
- NCT07695571
- Volunteers
- 300 people
- Sponsor
- Yasmin medhat munir Mohamed
Pediatric Kidney Transplantation
Model-Informed Precision Dosing of Tacrolimus in Pediatric Kidney Transplantation
The purpose of this study is to develop a novel and applicable dosing algorithm that helps support the clinical decision to achieve tacrolimus levels within the optimal immunosuppression range despite sparse sampling in routine…
- Trial name
- NCT07549230
- Volunteers
- 130 people
- Sponsor
- Helwan University
Model Informed Precision Dosing
Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children
Achieving optimal antibiotic exposure in critically ill pediatric patients is difficult due to (their) dynamic physiology and variability.
- Trial name
- NCT07315438
- Testing
- MIPD Tool
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University