Clinical trials: Movement Disorders
Class II Division 1 Malocclusion, Maxillary Prognathism
Laser-assisted Flapless Corticotomy in Accelerating Canine Retraction
Erbium lasers have been suggested to accomplish corticotomy without flap reflection due to their attractive advantages. The current trial aimed to evaluate the efficacy of laser-assisted flapless corticotomy in accelerating…
- Conditions
- Class II Division 1 Malocclusion, Maxillary Prognathism, Protrusion, Incisor
- Trial name
- NCT04316403
- Testing
- Er:YAG laser
- Where
- Syria
- Volunteers
- 18 people
- Sponsor
- Damascus University
Pulmonary Functions, Down Syndrome
Motorized Movement Therapy & Pulmonary Functions in Down Syndrome
To investigate the effects of the addition of motorized movement therapy versus conventional chest physiotherapy alone on pulmonary functions, exercise capacity, and endurance in children with Down Syndrome
- Trial name
- NCT04787861
- Testing
- motorized movement therapy
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Taibah University
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Multiple System Atrophy
Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France
This multicenter open-label extension study conducted in France is designed to provide ATH434 orally BID to eligible patients who completed the Phase 2 study ATH434-201, and who may benefit from this treatment according to the…
- Trial name
- NCT07729852
- Testing
- ATH434
- Where
- 4 sites in France
- Volunteers
- 7 people
- Sponsor
- Alterity Therapeutics
Cerebral Palsy, Spastic, Rehabilitation
A Pilot Study of Constraint Induced Movement Therapy in Preschool Cerebral Palsy After Botulism Toxin Injection
To establish a pilot randomized, crossover study on applying 2 constraint-induced movement therapy (CIMT) interventions in children with hemiplegic cerebral palsy after botulinum toxin injection during preschool education.
- Trial name
- NCT04179682
- Testing
- 40-hour constraint-induced movement therapy
- Volunteers
- 6 people
- Sponsor
- Changhua Christian Hospital
Microcephaly, Hyperkinesis With Developmental Delay
Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay
This trial will consist of a clinical series of up to 50 children with Global Developmental Delay and concomitant microcephaly or hyperkinetic movements.
- Conditions
- Microcephaly, Hyperkinesis With Developmental Delay, Global Developmental Delay
- Trial name
- NCT04816175
- Testing
- Acquire Therapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Polytechnic Institute and State University
Huntington's Disease
Coenzyme Q10 in Huntington's Disease (HD)
The goals of this trial are to determine if coenzyme Q10 is effective in slowing the worsening symptoms of Huntington's disease and to learn about the safety and acceptability of long-term coenzyme Q10 use by determining its…
- Trial name
- 2CARE (NCT00608881)
- Testing
- coenzyme Q10
- Where
- 49 sites in United States, Australia and 1 more
- Volunteers
- 609 people
- Sponsor
- Massachusetts General Hospital
Huntington Disease
Symptomatic Therapy for Patients With Huntington's Disease
Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.
- Trial name
- NCT04071639
- Testing
- Haloperidol 2Mg Tab, Risperidone 1Mg Tab, Zoloft 50Mg Tablet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson's Disease
Automated Telehealth Diagnostics for Remote Parkinson Monitoring
The objective is to clinically assess the Kinesia HomeView system for automated and remote monitoring of Parkinson's disease (PD) motor symptoms.
- Trial name
- PDRemote (NCT02152319)
- Testing
- KHV reporting, Standard care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Cerebral Palsy
Motion Analysis of Sit-to-Stand Movements in Children With Spastic Diplegia
The purpose of this study is to compare movement variations before and after the loaded training, with kinematics, kinetics, and electromyography, in children with spastic diplegia and to further discuss mechanisms of the loaded…
- Trial name
- NCT00314301
- Testing
- loaded sit-to-stand training
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Far Eastern Memorial Hospital
Parkinson Disease
Cue2Walk, Cost-effectiveness of Automated Freezing Detection and Provision of External Cues in Comparison to Usual Care in People With Parkinson's Disease
The majority of people with Parkinson's disease incur Freezing of Gait (FoG), which is not addressed adequately by medication. Cueing is a proven strategy to overcome FoG.
- Trial name
- NCT06416345
- Testing
- Cue2Walk, Usual Care
- Where
- 2 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Amsterdam UMC, location VUmc
Parkinson Disease
Treatment of Parkinson's Disease With a Transdermal Skin Patch
Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia.
- Trial name
- NCT00001931
- Testing
- N-0923
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections During Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control
This study examines the relationship between a cerebral hemisphere and control of muscles on the same side of the body (ipsilateral control).
- Trial name
- NCT00036595
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Class II Malocclusion
Which is Better Piezosurgery or LLLT in Accelerating Orthodontic Tooth Movement
Sixty patients requiring extraction-based treatment of the maxillary first premolars, followed by retraction of the maxillary canines, will be randomly assigned to three groups: piezocision, low-level laser therapy, and control.
- Trial name
- NCT05227859
- Testing
- Piezocision, Low-level laser, Conventional treatment
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Hemiplegia, Brain Tumor
Constraint-Induced Movement Therapy in a Pediatric Oncology Population
Hemiplegia (weakness or poor muscle function on one side of the body) is a neurological impairment which can occur in children as a result of a brain tumor or related treatment.
- Trial name
- SJCIT (NCT01447810)
- Testing
- Focused rigidity bi-valve long arm cast
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Jude Children's Research Hospital
Idiopathic Parkinson's Disease
Vascular Abnormalities in Idiopathic Parkinson's Disease
The purpose of this study is to use non-invasive Magnetic Resonance Imaging (MRI) scans to investigate venous insufficiency, brain iron levels and white matter hyperintensities (WMHs) to determine if there is direct correlation…
- Trial name
- IPD (NCT02045420)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Attention Deficit Disorder With Hyperactivity (ADHD), Attention Deficit Disorder (ADD)
A Quick and Reliable Eye Movement Test to Help Diagnose ADHD in Children.
Attention Deficit Hyperactivity Disorder (ADHD) affects more than 5 % of children and adolescents, with a globally increasing prevalence.
- Trial name
- ADHDin15? (NCT07136259)
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Onovis Augenpraxis
Angelman Syndrome
An Open-Label Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of OV101 in Individuals With Angelman Syndrome
This open-label study (OV101-18-002) will evaluate the long-term (52 weeks) safety of OV101 in subjects with AS and provide additional OV101 treatment to those subjects who completed Study OV101-15-001 (NCT02996305).
- Trial name
- ELARA (NCT03882918)
- Testing
- OV101
- Where
- 11 sites in United States, Israel
- Volunteers
- 141 people
- Sponsor
- Healx AI
Childhood Cancer, Cognitive Impairment
Cognitive and Motor Training in Pediatric Posterior Fossa Tumor Survivors
The purpose of this study is to create a rehabilitation program for children who survived posterior fossa tumors using the latest technology.
- Conditions
- Childhood Cancer, Cognitive Impairment, Motor Skills Disorders, Posterior Fossa Tumor
- Trial name
- NCT03951246
- Testing
- Cognitive and Motor Training
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Dystonia
Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical Network Dynamics in Dystonic Patients With Deep Brain Stimulation
The goal of this prospective open label study is to elucidate the pathophysiology of dystonia and to understand how deep brain stimulation (DBS) influences brain networks.
- Trial name
- DYScover (NCT06716983)
- Testing
- fMRI, EEG-MEG, registration of local field potentials
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
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