Clinical trials: Movement Disorders
Tourette Syndrome
Alternatives for Reducing Tics in Tourette Syndrome (TS): A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents
This is a study to evaluate the efficacy and safety of deutetrabenazine (TEV-50717) tablets for the reduction of motor and phonic tics associated with TS in children and adolescents 6 through 16 years of age.
- Trial name
- ARTISTS1 (NCT03452943)
- Testing
- TEV-50717
- Where
- 42 sites in United States, Canada and 4 more
- Volunteers
- 119 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Parkinson's Disease
Catechol Thioethers in Parkinson's Disease
The goal of the clinical trial aim in this project is to test whether catechol thioethers can be used as biomarkers of dopaminergic neurodegeneration.
- Trial name
- NCT00042692
- Volunteers
- 20 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Cerebral Palsy
A Longitudinal Study of Movement and Participation in Patients With Cerebral Palsy
The primary goal of this study is to establish and evaluate an image-based biomarker for the impaired motor control and sensory information processing present in Cerebral palsy (CP) patients
- Trial name
- NCT01903603
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
Effects of Cycling Dual-task in Parkinson's Disease.
Taking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the evolution of the pathology, the objective of this study is to evaluate the effect of a…
- Trial name
- NCT05565300
- Testing
- Cycling exercise, Cognitive tasks
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Vigo
Parkinson Disease, Essential Tremor
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03664609
- Testing
- Deep Brain Stimulation
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease
Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the…
- Trial name
- NCT07567599
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Parkinson's Disease
Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease
The study is designed to assess the long term tolerability of ProSavin and whether it is safe and efficacious in patients administered ProSavin from the PS1/001/07 study .
- Trial name
- NCT01856439
- Testing
- ProSavin
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Axovant Sciences Ltd.
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Rett Syndrome, MECP2 Duplication Disorder
Genetic and Physical Characteristics of Rett Syndrome
Rett Syndrome (RTT) is a genetic brain disorder that occurs almost exclusively in females and is usually caused by a change (mutation) in the gene MECP2.
- Conditions
- Rett Syndrome, MECP2 Duplication Disorder, Rett-related Disorder
- Trial name
- NCT00299312
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Hemiparesis
Comparing Virtual Reality Therapy With Modified-CIMT Versus Modified-CIMT Alone in Hemiparetic Children
This study intends to compare the efficacy of of virtual reality therapy(VRT) with modified constraint induced movement therapy(mCIMT) versus modified constraint induced movement therapy alone for children with hemiparetic…
- Trial name
- NCT03237520
- Testing
- Virtual Reality Therapy, mCIMT
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Parkinson Disease, Deep Brain Stimulation
Study on Brain Network Mechanism of Deep Brain Stimulation for Parkinson's Disease
As a surgical intervention, DBS can effectively relieve PD tremor, rigidity, bradykinesia and other symptoms. How to better screen patients suitable for DBS treatment and conduct reasonable preoperative and postoperative…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Non-motor Symptoms
- Trial name
- NCT05959161
- Testing
- DBS
- Volunteers
- 100 people
- Sponsor
- Tianjin Huanhu Hospital
Chronic Hip Joint Pain, Prearthritic Hip Disease
Movement Pattern Training in People With Intra-articular, Prearthritic Hip Disorders
Intra-articular, prearthritic hip disorders (PAHD) result in substantial dysfunction in young adults and are proposed precursors to hip osteoarthritis (OA).
- Trial name
- NCT02913222
- Testing
- Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Washington University School of Medicine
Angelman Syndrome, Chromosome 15q Duplication (dup15q) Syndrome
Angelman Syndrome (AS) Biomarker Study
The primary objective of this study is to measure ubiquitin-protein ligase E3A (UBE3A) protein levels in cerebrospinal fluid (CSF) and to evaluate its utility as a biomarker in support of the development of therapies for AS.
- Trial name
- NCT04103333
- Testing
- Lumbar Puncture, Blood Collection
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Biogen
Cerebral Palsy
Constraint-induced Movement Therapy and Self-regulation for Children With Cerebral Palsy
This study examines the effect of combining modified constraint-induced movement therapy (mCIMT) and self-regulation (SR) in promoting upper limb function of children with hemiplegic cerebral palsy (CP) studying in a school-based…
- Trial name
- NCT02957708
- Testing
- mCIMT + SR, Control
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- University of Western Sydney
Wilson Disease
The Clinical Study of Botulinum Toxin Type A Injection in the Treatment of Wilson Disease
In order to expand the treatment of Wilson disease and improve the quality of life of patients with Wilson's disease, the clinical effect of botulinum toxin type A injection on Wilson's disease was discussed.
- Trial name
- WD (NCT06762509)
- Testing
- Botulinum toxin type A
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Tic Disorders
Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children
This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations.
- Trial name
- NCT07351955
- Testing
- Transcranial Magnetic Stimulation, general behavioral therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Children's Medical Center
Gaucher Disease
OGT 918-006: A Phase I/II Randomized, Controlled Study of OGT 918 in Patients With Neuronopathic Gaucher Disease
Gaucher disease is an inherited functional deficiency of glucocerebrosidase. This enzyme breaks down a fatty substance (lipid) called glucocerebroside, which is present in all cells of the body.
- Trial name
- NCT00041535
- Testing
- OGT 918
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Premature Birth
Association Between Mother-Infant Attunement During Interaction and the Quality of General Movements
The proposed research has the potential of contributing to the limited empirical literature on the relationship between maternal sensitivity and motor development of preterm infants.
- Trial name
- NCT01764958
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Healthy, Strabismus
Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
Little is known about the development of the ocular, or eye, motor system (the parts of the brain that control how the eyes move) in children.
- Trial name
- NCT00001143
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Parkinson Disease, Perioperative Care
Perioperative Treatment of Parkinsonian Patients With Parenteral Amantadine
The purpose of this study is to determine whether administrating of Amantadine (a dopamine agonist) to patients suffering from Parkinson disease during the perioperative period is safe, and to asses potential benefits of this…
- Trial name
- NCT00600093
- Testing
- Amantadine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
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