Clinical trials: Movement Disorders
Post-Traumatic Stress Disorder, Depression
Efficacy of EMDR Versus CBT for Post-Traumatic Stress Disorder in Pakistan
This randomized controlled trial compares Eye Movement Desensitization and Reprocessing (EMDR) therapy with Cognitive Behavioral Therapy (CBT) for the treatment of post-traumatic stress disorder (PTSD) in Pakistan.
- Conditions
- Post-Traumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT06435052
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR) Therapy, Cognitive Behavioral Therapy (CBT)
- Where
- 3 sites in Pakistan
- Volunteers
- 80 people
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Parkinson's Disease
Genetic Polymorphism and Parkinson's Disease in Taiwanese
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.
- Trial name
- NCT01996878
- Where
- Taiwan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Malocclusion, Angle Class II
Effects of Power Arm Application in Maxillary Canine Distalization
The aim of this study is to investigate the effects of a canine distalization force applied between power arms placed on the maxillary canine and first molar, in comparison with the classical method without power arms.
- Conditions
- Malocclusion, Angle Class II, Tooth Movement Techniques, Orthodontic Anchorage Procedures
- Trial name
- NCT07866976
- Testing
- Canine and molar power arms, Conventional canine retraction
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Atlas University
Cardiac Disease, Respiratory Disease
Clinical Use Cases Assessment of the Gabi System in Young Children With Underlying Medical Conditions (BRIDGE Study)
Subjects will use the Gabi system on a daily basis for 3 months, each time the subject is resting or asleep. The Gabi system will recording the SpO2, pulse rate, respiratory rate and movements of the subject.
- Conditions
- Cardiac Disease, Respiratory Disease, Congenital Cardiac Defect, Cardiovascular Diseases
- Trial name
- BRIDGE (NCT05319236)
- Testing
- Gabi System
- Where
- 4 sites in United States, Belgium
- Volunteers
- 101 people
- Sponsor
- Gabi SmartCare
Parkinson's Disease
Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects, Elderly Subjects, and Patients With Parkinson's Disease
The purpose of this study is to investigate how changes in the brain associated with Parkinson's disease influence the control of motor and thinking speed.
- Trial name
- NCT00026598
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Pantothenate Kinase-Associated Neurodegeneration
Efficacy and Safety Study of Deferiprone in Patients With Pantothenate Kinase-associated Neurodegeneration (PKAN)
A multi-center, placebo controlled, double-blind trial comparing the efficacy and safety of 18 months of treatment with deferiprone versus placebo in patients with PKAN.
- Trial name
- NCT01741532
- Testing
- Deferiprone oral solution
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 89 people
- Sponsor
- ApoPharma
Tourette Syndrome
Safety and Efficacy of NBI-98854 in Pediatric Subjects With Tourette Syndrome
This is a Phase 2, double-blind, placebo-controlled, randomized withdrawal study to evaluate the safety and maintenance of efficacy of an optimized once-daily (qd) dose of NBI-98854 in pediatric subjects with TS.
- Trial name
- NCT03530293
- Testing
- Valbenazine
- Where
- 49 sites in United States, Puerto Rico
- Volunteers
- 81 people
- Sponsor
- Neurocrine Biosciences
Parkinson Disease
Can Dance Therapy Improve Motor Learning in Parkinson's Disease (PD)?
In order to find the most effective rehabilitative therapies for Parkinsonian patients, the present study is aimed to evaluate whether, in a multidisciplinary intensive rehabilitation treatment, the dance therapy, applied to the…
- Trial name
- NCT03549793
- Testing
- Dance Therapy, exercises without dance
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Wilson Disease
A Clinical Study to Evaluate the Safety and Efficacy of LY-M003 Injection in Patients With Wilson Disease
Wilson's disease (WD), also known as Wilson's disease, is a rare autosomal recessive metabolic disorder caused by a mutation of the copper transport ATPase β (ATP7B) gene located on the long arm of chromosome 13 (13q14.3).
- Trial name
- WD (NCT06650319)
- Testing
- LY-M003
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chaohui Yu
Parkinson Disease, Essential Tremor
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03664609
- Testing
- Deep Brain Stimulation
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease, Dexterity
Effectiveness of MIRT on Hand and Finger Dexterity in PD Patients
Aims of the study are (1) to evaluate the effectiveness of a specific OT treatment aimed to enhance finger and hand dexterity and (2) its impact on daily living autonomy of PD patients.
- Conditions
- Parkinson Disease, Dexterity, Rehabilitation
- Trial name
- H_F_ D_PD_MIRT (NCT03763955)
- Testing
- MIRT
- Volunteers
- 482 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Movement Disorders
Botulinum Toxin for the Treatment of Involuntary Movement Disorders
BTX has been used since the 1980s in support of the research mission of NINDS. Initial studies were focused on expanding the applicability of BTX treatment to movement disorders and exploring new indications.
- Trial name
- NCT00001208
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Angelman Syndrome
Angelman Syndrome Natural History Study
The goal of this study is to conduct a prospective, longitudinal natural history study of children and adults with Angelman Syndrome using investigator-observed and parent-reported outcome measures to obtain data that will be…
- Trial name
- NCT04507997
- Where
- 11 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Essential Tremor
Montreal Cognitive Assessment Index Following MRI Guided Focused Ultrasound Thalamotomy
We assessed Montreal Cognitive Assessment scores before and after MRI guided focused ultrasound thalamotomy for tremor in order to identify if there are changes in cognitive function following treatment.
- Trial name
- NCT06941285
- Testing
- Data collection
- Volunteers
- 142 people
- Sponsor
- Rambam Health Care Campus
Low Blood Pressure, Parkinsons Disease
The Effects of Nicotine Chewing Gum in Parkinson's Disease
The objective of this experiment is: To determine if nicotine chewing gum will improve acute episodes of orthostatic hypotension in PD subjects.
- Trial name
- PD (NCT02452125)
- Testing
- Nicotine gum
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Infant Development, Infant,Premature
Movement-based Infant Intervention
The objective is to pilot test the effectiveness of an evidence-based intervention to promote positive neurodevelopmental outcomes in infants at risk for developmental delay.
- Conditions
- Infant Development, Infant,Premature, Infant, Very Low Birth Weight, Infant, Small for Gestational Age
- Trial name
- NCT03082313
- Testing
- Movement Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
Angelman Syndrome
Study on the Brain Network of Angelman Syndrome
The aims of study on Angelman syndrome: 1. Establish the Angelman syndrome database 2. Explore the brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data
- Trial name
- NCT03358823
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fudan University
Parkinson's Disease
A Long-Term Extension Trial From of SPM 962 in Advanced Parkinson's Disease Patients
To investigate the safety of once-daily repeated transdermal administration of SPM 962 within a dose range of 4.5 to 36.0 mg/day (54-week treatment period) in Parkinson's disease (PD) patients treated concomitantly with L-dopa in…
- Trial name
- NCT01631825
- Testing
- SPM 962
- Where
- 8 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dental Malocclusion
Laser in Orthodontic Leveling and Alignment
to evaluate the outcome of LLLT regarding leveling and alignment of the mandibular anterior segment.
- Trial name
- NCT04376164
- Testing
- low level laser therapy
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Tharwat osman Mohi Eldeen Elshehawy
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