Clinical trials: Multi-omics
Healthy
Multi-omics Database Construction of Healthy Korean Volunteers
The goal of this prospective, observational study is to collect health-related data including microbiome, blood samples, and dietary habits from the oral and gastrointestinal tracts in healthy subjects.
- Trial name
- NCT06183697
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Aging
Large-scale Multi-omics Analysis of Cerebrospinal Fluid
The aim of this study is to explore the role of cerebrospinal fluid (CSF) biomarkers in aging and neurodegenerative diseases.
- Trial name
- NCT06636201
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis
Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With ARDS
This study is a prospective observational investigation designed to systematically characterize key microbial signatures, metabolite profiles, and gene-expression features in serum and sputum from patients with acute respiratory…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis, Multiomics Analysis, Metabolomics
- Trial name
- NCT07380997
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Head and Neck Cancer
Noninvasive Intratumor Heterogeneity Evaluation in HNSCC
This study focuses on tumor heterogeneity, a core challenge in the field of oncology, and innovatively utilizes patient imaging data to deeply mine and analyze intratumoral heterogeneity.
- Trial name
- NCT07027280
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Hereditary Ataxia
Hereditary Ataxia Research on Multi-Omics and Neuroclinical Insights in the Yangtze Delta
The goal of this observational study is to explore the clinical and genetic characteristics, multi-omics profiles, disease mechanisms, biomarkers, and potential therapeutic targets of hereditary ataxia (HA) in patients diagnosed…
- Trial name
- HARMONY (NCT07092358)
- Testing
- None of intervention
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autism, Gastro Intestinal Diseases
Identifying Biomarkers of Gastro Intestinal Comorbidities in Autism Spectrum Disorder
This study investigates the microbiome-gut-brain axis in pediatric autism spectrum disorder (ASD). By longitudinally tracking participants, the study evaluates whether multi-omic profiles (gut microbiota and metabolome) correlate…
- Trial name
- NCT07744217
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Center for Discovery
Rare Intellectual Disabilities
Multi-Omics and IPSCs to Improve Diagnosis of Rare Intellectual Disabilities
Background Genetic factors play a major role in intellectual disability (ID) but the underlying cause is not determined in many cases.
- Trial name
- MIDRID (NCT03635294)
- Testing
- Blood sample
- Where
- 6 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Angers
Ureteral Stricture, Ureteral Obstruction
An Integrated Multi-omics Study on the Molecular Mechanisms of Ureteral Stricture
The goal of this observational study is to investigate the systemic pathogenesis and identify potential diagnostic biomarkers in patients with ureteral stricture and healthy volunteers.
- Conditions
- Ureteral Stricture, Ureteral Obstruction, Microbiome, Metabolomics
- Trial name
- US-MOP (NCT07409870)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Human Microbiome, Pediatrics
Human Microbiome Research and Development for Overcoming Pediatric Diseases
Prediction and treatment of pediatric diseases and long-term outcomes through microbiome and multi-omics analysis by life cycle: We aim to demonstrate that a wide range of diseases are associated with gut microbiome dysbiosis and…
- Conditions
- Human Microbiome, Pediatrics, Disease, Growth & Development
- Trial name
- NCT06812091
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Severe Eosinophilic ACOS (Asthma-COPD Overlap)
Blood Exosomal Multi-omics and Lung Radiomics for Predicting Efficacy and Prognosis of Severe Eosinophilic ACOS With Biologics
Firstly, to screen blood exosomal multi-omics (transcriptomics, proteomics, metabolomics) and lung radiomics (HRCT, Xe129MRI) biomarkers that can predict efficacy and prognosis in severe eosinophilic ACOS (asthma-COPD overlap)…
- Trial name
- ACOS (NCT07602881)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
ATRT
Finding New Targets by Proteomic Approaches (InnovRT1)
The investigators aim to explore the inter tumor heterogeneity by a proteomic approach of a wide series of rhabdoid tumors, from both intra and extra cranial origins.
- Trial name
- InnovRT1 (NCT04868799)
- Testing
- Mass spectrometry
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myeloma Multiple, Chronic Leukemia
Feasibility of a Multi-omics Platform for Hematological Malignancies
This is a biological study based on a collaborative effort involving several Italian haematology centres (including the coordinating centre).
- Conditions
- Myeloma Multiple, Chronic Leukemia, Acute Leukemia, Myeloproliferative Disorders
- Trial name
- FOCUS (NCT07445438)
- Testing
- Multi-omics analyses, Functional tests
- Where
- Italy
- Volunteers
- 1,040 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Mental Disorders, Healthy Control
Psychiatric Multi-omics and Neuroimaging Project
This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three.
- Trial name
- PMNP (NCT06580860)
- Testing
- Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
- Where
- China
- Volunteers
- 1,899 people, healthy volunteers welcome
- Sponsor
- mingjun Zhong
Intellectual Disability, Neurodevelopmental Disorder (Diagnosis)
Integration of New Generation Multi-omics Analyses for the Diagnosis of Genetic Neurodevelomental Disorders
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), represent the most common indication for genetic testing.
- Conditions
- Intellectual Disability, Neurodevelopmental Disorder (Diagnosis), srGS, lrGS
- Trial name
- NEXTOMIX (NCT07755098)
- Testing
- Re-analysis of available srGS data, Re-analysis of available srGS data, followed by complementary analyses (lrGS sequencing, mRNA, and GMOs), srGS sequencing
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Genetic Disease
iKnow: A Prospective Study to Evaluate the Use of Multi-omics in Multi-System, Early Onset Disorders
Prospective observational study to further understand the value that a multi-omic approach has in individuals with a multi system, early onset disorder that does not have a molecular diagnosis by whole genome sequencing.
- Trial name
- iKnow (NCT05049967)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Illumina, Inc.
Bladder Cancer, Staging
Bladder Cancer Staging and Prediction of New Adjuvant Chemotherapy Efficacy Based on Deep Learning and Transfer Learning in Ultrasound-Magnetic Resonance-Pathology Multimodal Multiscale
Bladder cancer is the most common malignant tumor of the urinary system. The presence or absence of muscle invasion in early bladder cancer is an independent prognostic factor.
- Conditions
- Bladder Cancer, Staging, Deep Learning, Neoadjuvant Chemotherapy
- Trial name
- MICS-BC (NCT07051083)
- Testing
- Risk Stratification
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Mitochondrial Diseases
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases
MITOMICS aims to determine which RNA-Seq results (from muscle or fibroblasts) are the most informative for the interpretation of VUS identified by WES for patients suspected of mitochondrial myopathy.
- Trial name
- MITOMICS (NCT04920812)
- Testing
- diagnosis of mitochondrial myopathy
- Where
- 9 sites in France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inflammatory Bowel Diseases, Ulcerative Colitis
Gut Microbiome in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition for gastrointestinal tract. There have been numerous studies to reveal dysbiosis of fecal/mucosal microbiome composition in IBD patients but actual trend of…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT03589183
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Kyunghee University Medical Center