Clinical trials: Multiorgan Failure, open to volunteers
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Critical Illness, Multiple Organ Dysfunction Syndrome
pSOFA Score in Predicting Mortality in Pediatric Intensive Care
This prospective observational cohort study aims to evaluate the predictive performance of the Pediatric Sequential Organ Failure Assessment (pSOFA) score for mortality and selected clinical outcomes among critically ill children…
- Trial name
- NCT07858487
- Volunteers
- 121 people
- Sponsor
- Assiut University
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced…
- Trial name
- TRIPS (NCT05267821)
- Testing
- Anakinra
- Where
- 32 sites in United States
- Volunteers
- 500 people
- Sponsor
- Nationwide Children's Hospital
ICU Mortality (Survival Rate)
FOUR-Based Modification of ICU Severity Scores
The goal of this observational study is to evaluate whether the Full Outline of UnResponsiveness (FOUR) score can replace the Glasgow Coma Scale (GCS) as the neurologic component of established intensive care unit (ICU) severity…
- Trial name
- FOUR-ICU (NCT07832773)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
The Study Seeks to Determine Potential Correlations Between Ventilation and Hematological Alterations, Contributing to a Better Understanding of Its Physiological Effects and Optimizing Patient Management in Critical Care Settings.
The study seeks to determine potential correlations between ventilation and hematological alterations, contributing to a better understanding of its physiological effects and optimizing patient management in critical care…
- Trial name
- NCT07030114
- Testing
- complete blood tests, mechanical ventilation (MV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Critical Illness, Acute Kidney Injury
Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT04033224
- Testing
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
- Where
- 15 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Careggi Hospital