Clinical trials: Multiple
Loeys-Dietz Syndrome
Immunopathology of Loeys-Dietz Syndrome
Loeys-Dietz syndrome (LDS) is a rare vascular genetic disorder (estimated prevalence 1/25,000-1/100,000) due primarily to mutations in the Transforming growth factor beta (TGF-β) cytokine receptor 1 and 2 genes.
- Trial name
- I-LoDiS (NCT05472519)
- Testing
- blood samples
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Mydriasis
Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation
This study evaluated pupil dilation after administration of fixed combination tropicamide-phenylephrine (TR/PH) vs. placebo. Participants attended 3 visits.
- Trial name
- MIST-2 (NCT03751098)
- Testing
- Tropicamide/Phenylephrine ophthalmic solution (TR/PE)
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Patient Safety
Medical Safety Huddles - a Multi-site QI Project
This quality improvement project will implement and evaluate the impact of physician-specific huddles, termed "medical safety huddles" on patient safety within four programs/sites at Sinai Health Systems, St.
- Trial name
- NCT05365516
- Testing
- Implementing medical safety huddles
- Where
- 4 sites in Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Chlamydia
Multi-level Interventions for STD Prevention Among Adolescents
Sexually active adolescents between the ages of 10 and 19 are at extremely high risk for sexually transmitted diseases (STD), including HIV, and teen pregnancy.The overall goal of this research program is to develop, implement…
- Trial name
- NCT00146406
- Testing
- Project Connect
- Where
- United States
- Volunteers
- 36,502 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Leukemia, Lymphoma
Blood Samples to Identify Biomarkers of Busulfan
Specific Aim 1: To determine whether endogenous metabolomics-based biomarkers obtained before IV BU administration can predict IV BU clearance. Specific Aim 2: To characterize IV BU metabolism by metabolomics.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma, Immunodeficiency
- Trial name
- NCT02291965
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Fred Hutchinson Cancer Center
Haemophilia A, Haemophilia B
Post-marketing Surveillance (Special Use-results Surveillance) on Treatment With Alhemo
The purpose of the study is to investigate the safety and effectiveness of Alhemo in participants under real-world clinical practice in Japan. Total duration of this study is about 6 years.
- Trial name
- NCT06831734
- Testing
- Concizumab
- Where
- 23 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
Myopia
Effectiveness of Myopia Control Interventions : A Comparison of Myopia Control in European Children, Adolescents and Young Adults With Defocus Incorporated Multiple Segments (DIMS) and Highly Aspherical Lenslets (HAL) Spectacles, Atropine, Lenses and Combined Treatments
The prevalence of myopia and its complications has risen considerably in recent decades, particularly among children and teenagers.
- Trial name
- NCT07120165
- Testing
- Demographic data collection, Ophthalmological history, Ophthalmological data at each examination
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sarcoma
High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma
RATIONALE: Drugs used in chemotherapy, such as vincristine, irinotecan, ifosfamide, etoposide, doxorubicin, cyclophosphamide, and dactinomycin, work in different ways to stop the growth of tumor cells, either by killing the cells…
- Trial name
- NCT00354744
- Testing
- dactinomycin, cyclophosphamide, doxorubicin hydrochloride
- Where
- 166 sites in United States, Australia and 3 more
- Volunteers
- 109 people
- Sponsor
- Children's Oncology Group
Prader Willi Syndrome
Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants
The Prader-Willi syndrome (PWS) includes severe neonatal hypotonia with impaired suckling leading to failure to thrive in the most severe cases, subsequently followed by an early onset of morbid obesity with hyperphagia and…
- Trial name
- OTBB2 (NCT02205034)
- Testing
- oxytocin
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Beta-thalassemia Major, Hemosiderosis
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)
To allow patients treated with deferasirox in the core study to continue iron chelation therapy for 2 years or until the drug became locally commercially available.
- Conditions
- Beta-thalassemia Major, Hemosiderosis, Iron Overload, Rare Anemia
- Trial name
- ESCALATOR (NCT00171301)
- Testing
- Deferasirox
- Where
- 5 sites in Egypt, Lebanon and 3 more
- Volunteers
- 233 people
- Sponsor
- Novartis Pharmaceuticals
Epithelial Ovarian Cancer, Acute Kidney Injury Due to Circulatory Failure
Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy
Ovarian cancer is the most lethal malignancy of the female genital tract. Cytoreductive surgery combined with chemotherapy is the primary treatment for ovarian cancer, and radical tumor resection is an important means to improve…
- Trial name
- NCT05877911
- Testing
- Sodium Sulfate, Hydration, Cisplatin
- Volunteers
- 110 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Clinical Response, Histopathological Response
Clinical Evaluation of Neoadjuvant Chemotherapy for Primary Malignant Sarcomas That Originate in Bone
For bone lesions treated with chemotherapy or targeted therapy, particularly for sarcomas that originate in bones, Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 is spurious because bone lesions are typically located…
- Conditions
- Clinical Response, Histopathological Response, Prognosis
- Trial name
- CESOFB-00 (NCT03742063)
- Testing
- first-line chemotherapy
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Peking University People's Hospital
Systemic Juvenile Idiopathic Arthritis
Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA)
This study is a pilot, ascending dose, multi-center, randomized, double blind, placebo controlled, pediatric study conducted in three phases.
- Trial name
- NCT01803321
- Testing
- rilonacept (IL-1 Trap)
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Regeneron Pharmaceuticals
Pregnant Women, Pregnant Women and Their Offspring
Effectiveness of MMS Compared With IFS Among Pregnant Women in Bangladesh: an Experimental Study
Background Maternal undernutrition and micronutrient deficiencies remain highly prevalent in Bangladesh and contribute to maternal anaemia, low birth weight, preterm birth, and adverse neonatal outcomes.
- Trial name
- NCT07540130
- Testing
- Multiple micronutrient supplementation
- Where
- Bangladesh
- Volunteers
- 667 people
- Sponsor
- National Institute of Neurosciences and Hospital, Dhaka
Cardiovascular Diseases, Heart Diseases
Genome Scan for Obesity in a Multi-Ethnic Sample
To scan the genome for obesity in a multi-ethnic sample.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00037271
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Duchenne Muscular Dystrophy
Phase I/II Study of PRO044 in Duchenne Muscular Dystrophy (DMD)
The purpose of this study is to see whether PRO044 is safe and effective to use as medication for DMD patients with a mutation around location 44 in the DNA for the dystrophin protein.
- Trial name
- NCT01037309
- Testing
- PRO044 SC, PRO044 IV
- Where
- 4 sites in Belgium, Italy and 2 more
- Volunteers
- 18 people
- Sponsor
- BioMarin Pharmaceutical
Gastric Ulcer (GU), Duodenal Ulcer (DU)
A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases
The objective of this study is to assess the safety, pharmacokinetics, pharmacodynamics and efficacy of repeated once daily oral administration of D961H 10 mg and D961H 20 mg in Japanese paediatric patients aged 1 to 14 years old…
- Conditions
- Gastric Ulcer (GU), Duodenal Ulcer (DU), Anastomotic Ulcer (AU), Non-erosive Reflux Esophagitis Disease (NERD)
- Trial name
- NCT02153398
- Testing
- D961H sachet 10 mg, D961H capsule 10mg, D961H capsule 20 mg
- Where
- 15 sites in Japan
- Volunteers
- 55 people
- Sponsor
- AstraZeneca
Pachyonychia Congenita
Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita
Pachyonychia congenita (PC) is a rare, autosomal dominant keratin disorder affecting the nails, skin, oral mucosae, larynx, hair and teeth.
- Trial name
- NCT00716014
- Testing
- TD101
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pachyonychia Congenita Project
Atopic Dermatitis
Study of Generic Pimecrolimus Cream, 1% in the Treatment of Mild to Moderate Atopic Dermatitis
This is a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multiple-Site Study to Evaluate the Therapeutic Equivalence of a Generic Pimecrolimus Cream, 1% (Glenmark Pharmaceuticals Ltd) to the Marketed Product…
- Trial name
- NCT02896101
- Testing
- Pimecrolimus Cream, 1%, Elidel® (pimecrolimus) Cream
- Where
- 27 sites in United States
- Volunteers
- 755 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Eye Involvement of Systemic Diseaes, Adverse Drug Effect on Eye
the SDMEAI Study: a Multi-center Epidemiological Study
A variety of diseases in the Department of Rheumatology, Immunology, Nephrology, and Gastroenterology can cause eye lesions, and medications can also bring various adverse reactions, which can seriously reduce the quality of…
- Conditions
- Eye Involvement of Systemic Diseaes, Adverse Drug Effect on Eye, Artificial Intelligence
- Trial name
- NCT04849819
- Testing
- Corticosteroids, immunosuppressors, biological agents
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
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