Clinical trials: Multiple
Autoimmunity, Inflammation
Secukinumab Open Label Roll-over Extension Protocol
The purpose of this study is to assess long term safety in participants who have completed a Novartis trial with secukinumab, have been judged by the investigator to benefit from continued treatment with secukinumab, and are…
- Trial name
- NCT04638647
- Testing
- Secukinumab s.c. injection
- Where
- 171 sites in United States, Brazil and 18 more
- Volunteers
- 1,000 people
- Sponsor
- Novartis Pharmaceuticals
Down Syndrome
Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome
The main aims of the present project include 1) to study the longitudinal effects of whole-body vibratory exercise on bone metabolism in adolescents with and without DS and 2) to evaluate whether a low frequency vibratory…
- Trial name
- NCT02380638
- Testing
- Whole-body vibration training (Power Plate®) on bone mass and bone metabolism in adolescents with and without Down syndrome.
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Acute Myeloid Leukemia
A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)
To find a recommended dose of ASTX727 (cedazuridine/decitabine) in combination with venetoclax for pediatric patients with relapsed AML.
- Trial name
- NCT06191978
- Testing
- ASTX727, Venetoclax
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Molluscum Contagiosum
A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum
This trial will examine the safety, tolerability and efficacy of one strength of East Indian sandalwood oil (EISO) in a cream base compared to a placebo for treatment of molluscum contagiosum in pediatric subjects.
- Trial name
- NCT02024581
- Testing
- 10% East Indian sandalwood oil cream
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- ViroXis Corporation
Dravet Syndrome
Safety and Tolerability of Clobazam as Adjunctive Therapy in Paediatric Patients Aged ≥1 to ≤16 Years With Dravet Syndrome
To investigate the long-term safety and tolerability of clobazam when administered for 1 year as adjunctive therapy in paediatric patients aged ≥1 to ≤16 years with Dravet Syndrome.
- Trial name
- NCT02187809
- Testing
- Clobazam
- Where
- 9 sites in United States, Mexico
- Volunteers
- 3 people
- Sponsor
- H. Lundbeck A/S
Premature Birth, Late-onset Invasive Infection
Speed of Increasing Milk Feeds Trial
Survival of preterm infants has increased greatly over the years, so a major aim now is to improve the long term outlook for these babies and to avoid serious complications.
- Conditions
- Premature Birth, Late-onset Invasive Infection, Necrotizing Enterocolitis
- Trial name
- SIFT (NCT01727609)
- Testing
- Milk feed (breast milk or formula milk)
- Where
- 57 sites in Ireland, United Kingdom
- Volunteers
- 2,804 people
- Sponsor
- University of Oxford
Neoplasms, Arteriovenous Malformation of Central Nervous System
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
The RSSearch® Registry is an international multi-year database designed to track SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) utilization, treatment practices and outcomes to help determine, over time…
- Conditions
- Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
- Trial name
- NCT01885299
- Testing
- SRS/SBRT
- Where
- 13 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- The Radiosurgery Society
Renal Function Disorder
Development and Validation of Creatinine-Based Estimates of the Glomerular Filtration Rate Equation
This study aim to recruit all Electronic Medical Record of patients who underwent for 51chromium ethylenediamine tetra acetic acid (51Cr-EDTA) imaging at the Nuclear Medicine Centre, University Malaya Medical Centre from…
- Trial name
- NCT05112393
- Testing
- Development of new estimating Glomerular Filtration Rate (eGFR) equation, Validation of new estimating Glomerular Filtration Rate (eGFR) equation
- Where
- Malaysia
- Volunteers
- 200 people
- Sponsor
- University of Malaya
Learning Disabilities, Cerebral Palsy
Efficacy of AAC for Functional Communication
There is a considerable number children who are unable to speak, and our currently not being provided with any AAC options in their therapeutic facilities.
- Conditions
- Learning Disabilities, Cerebral Palsy, Down Syndrome
- Trial name
- NCT04583332
- Testing
- Rhymes, Individual Items in Rhymes, Objects
- Where
- Pakistan
- Volunteers
- 12 people
- Sponsor
- Riphah International University
Baby Formula, Growth Equivalence, Neurocognitive Development, Healthy Infants
Growth and Health Outcomes of a New Infant- and follow-on Formula for Healthy Term Infants.
To demonstrate growth equivalence of a Baby formula Test Product when compared to the Control product after 16 weeks. And to demonstrate better neurocognitive development at 52 weeks post-baseline in subjects receiving the Test…
- Trial name
- GAIA (NCT06475521)
- Testing
- Infant Formula
- Where
- 2 sites in Bulgaria, Poland
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Primary Ciliary Dyskinesia, Kartagener Syndrome
Diagnosis of Primary Ciliary Dyskinesia
Primary ciliary dyskinesia is an inherited respiratory disease caused by various functional and ultrastructural abnormalities of respiratory cilia.
- Trial name
- DCP (NCT00783887)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD (Chronic Obstructive Pulmonary Disease), COPD
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study aims to see if a co-designed balance training programme called Sport4Steadiness (S4S), is acceptable to people with COPD and if the study procedures, including recruitment and the collection of outcomes, is feasible.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Balance Exercise, Falls, Intervention
- Trial name
- B-PuRe (NCT07750821)
- Testing
- Sport4Steadiness
- Where
- 3 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Samantha Harrison
Obstructive Sleep Apnea of Child
Surgical Treatment of Children With OSA and Small Tonsils or Down Syndrome
The purpose of this study is to prospectively compare the effectiveness of a novel personalized approach to the surgical treatment of obstructive sleep apnea (OSA) in children, drug induced sleep endoscopy (DISE) directed surgery…
- Trial name
- NCT05154214
- Testing
- Adenotonsillectomy, Drug-induced sleep endoscopy directed surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Hypothalamic Obesity, Prader-Willi Syndrome
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment
- Conditions
- Hypothalamic Obesity, Prader-Willi Syndrome, PWS
- Trial name
- NCT06239116
- Testing
- Part C: RM-718, Part D: RM-718
- Where
- 7 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004232
- Testing
- filgrastim, cyclosporine, methylprednisolone
- Where
- United States
- Sponsor
- Northwestern University
22q11 Deletion Syndrome
NB-001 in Children and Adolescents With 22q11 Deletion Syndrome
This is a Phase 2, randomized, placebo-controlled crossover trial to assess the safety and efficacy of NB-001 in children and adolescents with 22q11DS that manifest commonly associated neuropsychiatric symptoms.
- Trial name
- NCT05290493
- Testing
- NB-001
- Where
- 4 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Nobias Therapeutics, Inc.
Attention Deficit Hyperactivity Disorder
Multi Neuro-functional Biomarkers for Monitoring the Effects of Treatments in ADHD Children
MIMOSA study aims to characterize from behavioral, neurophysiological and neurocognitive perspectives children and adolescents with attention deficit hyperactivity disorder (ADHD), in order to identify a possible biomarker of…
- Trial name
- MIMOSA (NCT04272021)
- Testing
- Methylphenidate
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Down Syndrome
Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome
Background: Down syndrome (DS) has unique physical, motor and cognitive characteristics. Despite cognitive and motor difficulties, there is a possibility of intervention based on the knowledge of motor learning.
- Trial name
- NCT02719600
- Testing
- Virtual reality
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Domestic Violence, PTSD
'Effectively Intervening in Traumatized Parents and Young Children After Structural Domestic Violence: A Multiple Baseline Analysis'
The goal of this study is to evaluate the effectiveness of an individualized treatment trajectory in which the order of trauma therapy for the parent (Eye movement desensitization and reprocessing (EMDR) therapy), trauma therapy…
- Trial name
- NCT06065865
- Testing
- Guidance document
- Where
- Netherlands
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Necrotizing Enterocolitis, Intra-abdominal Infection
Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections
Meropenem is an antibiotic that is commonly used to treat serious infections. Although it is used in premature and young infants, the correct dose is not known.
- Trial name
- NCT00621192
- Testing
- meropenem
- Where
- 26 sites in United States
- Volunteers
- 200 people
- Sponsor
- The Emmes Company, LLC
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