Clinical trials: Muscle Diseases
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Pediatric Cancer, Nutrition Related Cancer
Pediatric Oncology Nutrition Intervention Trial
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a combination of disease burden, side effects of chemotherapy, and the intensity of cancer treatment.
- Conditions
- Pediatric Cancer, Nutrition Related Cancer, Nutrition Aspect of Cancer, Muscle Loss
- Trial name
- POINT (NCT06175273)
- Testing
- Oral Nutrition Supplement, Tube Feed, Cyproheptadine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corey Hawes
Muscular Dystrophy
Heart Imaging in Children With Muscular Dystrophy
Background: Muscular dystrophy can affect the muscles used for heart function and breathing. Treatment usually involves drugs that help improve heart function.
- Trial name
- NCT01633242
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fibrodysplasia Ossificans Progressiva (FOP)
A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Primary Objective(s): To describe the demographic characteristics of people living with FOP and a matched cohort of non-FOP people living in the United States (U.S.) To describe the prevalence of clinical characteristics of…
- Trial name
- NCT06064656
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Regeneron Pharmaceuticals
Intraabdominal Hypertension, Breast Neoplasms
DIEP Flap Surgery and Intraabdominal Pressure
Aim: The primary aim of this study is to test if closure of the abdominal donor site increases the Intraabdominal Pressure (IAP) in women undergoing secondary Deep Inferior epigastric perforator (DIEP) flap breast reconstruction.
- Trial name
- NCT05764577
- Testing
- DIEP flap surgery
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Aalborg University Hospital
Subacromial Impingement Syndrome
Comparison of Platelet-Rich Plasma and Additional Exercise and Exercise Only in Subacromial Impingement Syndrome
Aim: The aim of this study is to compare the effects of platelet-rich plasma application with additional exercise and only exercise application on pain, muscle strength, functionality and quality of life in subacromial…
- Trial name
- NCT05248061
- Testing
- Group A, Group B
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- University of Beykent
Spastic Cerebral Palsy
Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
This study will investigate the effect of a 6-week stretching intervention, consisting of a combination of a 2-week casting period and a home-based stretching program of the plantar flexors and hamstrings, on muscle and tendon…
- Trial name
- NCT04904094
- Testing
- Casting of the lower limb and homebased stretching exercise program.
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
This study will examine the effectiveness of injected hylan (Synvisc) for treating pain associated with osteoarthritis of the temporomandibular joint (jaw joint) and improving function of the joint.
- Trial name
- NCT00078351
- Testing
- High molecular weight hylan (Synvisc) injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Rhabdomyolysis
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats
This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1…
- Trial name
- NCT06491394
- Testing
- Lactoferrin, iron, MDA, TAC, and GSH
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Aswan University Hospital
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Lower Urinary Tract Symptoms
Connective Tissue Manipulation on Pelvic Floor Muscle Functions in Children
Lower urinary tract dysfunction (LUTD) is a disease group with subgroups that make up 40% of the patients were admitted to the pediatric urology clinic.
- Trial name
- NCT05824429
- Testing
- Urotherapy, Diaphragmatic Breathing Exercises, PFM Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yeditepe University
Spinal Muscular Atrophy
An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
This objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics of a single dose of nusinersen (ISIS 396443) administered intrathecally to participants with Spinal Muscular Atrophy (SMA).
- Trial name
- SMNRx (NCT01494701)
- Testing
- nusinersen
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- Biogen
Fatigue Syndrome, Chronic, Epstein-Barr Virus Infection
Mental Training for CFS Following EBV Infection in Adolescents
The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection.
- Trial name
- NCT02499302
- Testing
- Mental training
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Nemaline Myopathy
Treatment of TNNT1-Myopathy With L-Tyrosine.
The purpose of the study is to investigate if treatment with L-Tyrosine improves selected outcome measures of TNNT1 myopathy.
- Trial name
- NCT02035501
- Testing
- L-Tyrosine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Muscular Dystrophy, Duchenne
Characterization of DupEx2 Duchenne Muscular Dystrophy
To characterize the clinical phenotype and possible predictive/prognostic factors of patients with Duchenne muscular dystrophy (DMD) due to duplication of exon 2 (Dup2).
- Trial name
- DMDDup2 (NCT06337669)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS San Raffaele
Autism
The Effect of Pilates on Muscle Strength, Balance Performance, Gross Motor Skills, Social Skills in Children With ASD
The purpose of this randomized controlled study was to determine the effects of Pilates Training by comparing the effects of Aerobic Training on muscle strength, balance performance, gross motor skills and social skills in…
- Trial name
- NCT05458466
- Testing
- Pilates training
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Aydin Adnan Menderes University
Becker Muscular Dystrophy
Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping
This is a multi-center natural history study that will be conducted at participating centers in the Cooperative International Neuromuscular Research Group (CINRG).
- Trial name
- NCT01539772
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 85 people
- Sponsor
- Cooperative International Neuromuscular Research Group
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