Clinical trials: Muscle Disorders
Duchenne Muscular Dystrophy
An Observational Study Comparing Delandistrogene Moxeparvovec (ELEVIDYS) With Standard of Care in Participants With Duchenne Muscular Dystrophy
This is a multicenter, prospective, observational Phase 4 study including a post marketing safety requirement, designed to collect both medical history data and prospective data on Duchenne muscular dystrophy (DMD) treatment…
- Trial name
- ENDURE (NCT06270719)
- Testing
- Delandistrogene Moxeparvovec, Standard of Care
- Where
- 29 sites in United States
- Volunteers
- 500 people
- Sponsor
- Sarepta Therapeutics, Inc.
Preeclampsia
The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia
The goal of this clinical trial is to learn about in health conditions. The main questions it aims to answer are: The pathological significance of GPER in uterine artery dilation in preeclampsia The Mechanism of GPER Hippo…
- Trial name
- NCT06205771
- Testing
- H2S content
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hao Feng
Infant, Extremely Low Birth Weight, Lung Diseases, Obstructive
Growth, Health and Development in Children Born Extremely Preterm
Background: In a national Norwegian cohort of children born before 28 weeks gestation or with a birth weight less than 1000 g born in 1999 and 2000, 372 survived.
- Conditions
- Infant, Extremely Low Birth Weight, Lung Diseases, Obstructive, Disorder of Bone Density and Structure, Unspecified, Cognition Disorders
- Trial name
- PEP11 (NCT01150071)
- Where
- 2 sites in Norway
- Volunteers
- 232 people
- Sponsor
- University of Bergen
Osteoporosis, Muscular Dystrophy
Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy
By supplying an adequate amount of calcium and vitamin D with the addition of weekly bisphosphonate, the investigators will be able to increase bone mass and decrease the incidence of fragility fractures in these children with…
- Conditions
- Osteoporosis, Muscular Dystrophy, Cystic Fibrosis
- Trial name
- NCT01882400
- Testing
- Bisphosphonate treatment
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Gilles Boire
Cystic Fibrosis (CF), Primary Ciliary Dyskinesia (PCD)
Exercise Capacity, Muscle Oxygenation, Respiratory Muscle Strength, and Physical Activity Level in Pediatric CF and PCD
Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are genetic diseases characterized by chronic respiratory tract infections.
- Trial name
- NCT07157644
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Gazi University
Myofascial Trigger Points, Musculoskeletal Pain
Ischemic Compression and Home Exercise in Non-Specific Neck Pain
The purpose of this study is to investigate the effects of ischemic compression combined with home exercise on pain, cervical range of motion, neck disability level, and quality of life in individuals with non-specific neck pain.
- Conditions
- Myofascial Trigger Points, Musculoskeletal Pain, Non-specific Neck Pain, Neck Pain
- Trial name
- NSNP (NCT07685418)
- Testing
- Ischemic Compression, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul Rumeli University
Muscular Atrophy, Spinal
International SMA Patient Registry
This is a registry of individuals affected by Spinal Muscular Atrophy (SMA) and/or family members of individuals affected by SMA.
- Trial name
- NCT00466349
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Indiana University
Deglutition Disorder
Effect of Pre-emptive Transcutaneous Neuro-muscular Electrical Stimulation for Dysphagia in Long Term Intubated Patients
It was well known that long term intubation caused a various kind of abnormal presentations of dysphagia such as the increased aspiration risk, the decreased gag reflex, mucosal pathology, the airway stenosis and so on.
- Trial name
- NCT01202968
- Testing
- Transcutaneous neuro-muscular electrical stimulation
- Where
- South Korea
- Sponsor
- Ulsan University Hospital
Muscular Dystrophies
LARA: Use of JACO2 Controlled by Joystick or by Voice Control System, in Muscular Dystrophy
As part of the EMPATIA @ Lecco project, task 2.9 and task 4.5 respectively provide for the refinement and testing of robotic solutions on the market oriented towards patient empowerment.
- Trial name
- NCT04313049
- Testing
- JACO2, VOCAL CONTROL
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Juvenile Idiopathic Arthritis
Inspiratory Muscle Training in Juvenile Idiopathic Arthritis
The aim of this study is to investigate the effectiveness of inspiratory muscle training (IMT) in increasing respiratory muscle strength in patients with juvenile idiopathic arthritis.
- Trial name
- NCT05482633
- Testing
- Inspiratory muscle training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Izmir Katip Celebi University
Scoliosis; Adolescence, Myofascial Pain Syndrome
Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis
this is an observational and cross-sectional prevalence study. 10-18 years aged participants with adolescent idiopathic scoliosis were recruited in the study. Myofascial pain syndrome will be questioned to the participants.
- Conditions
- Scoliosis; Adolescence, Myofascial Pain Syndrome, Trigger Point Pain, Myofascial, Physical Medicine and Rehabilitation
- Trial name
- NCT05185050
- Testing
- physical examination and measurement of spinal alignment
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness
Efficacy of Inspiratory Muscle Training on Elite Swimmers
This study is a randomized controlled trial on the efficacy of inspiratory muscle training on swimming performance, airway dysfunction and perceived breathlessness in elite swimmers.
- Conditions
- Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness, Dyspnea
- Trial name
- PEAK (NCT03062735)
- Testing
- Inspiratory Muscle Training
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Muscle Weakness, Critical Illness
Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
- Trial name
- NCT00893633
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Clinical Institute of the Brain, Russia
Primary Ciliary Dyskinesia
Muscle Function, Exercise Capacity and Physical Activity Level in Primary Ciliary Dyskinesia and Kartagener Syndrome
Studies evaluating respiratory and peripheral muscle functions in PCD patients and comparing them with healthy children are limited in the literature.
- Trial name
- NCT05816876
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Gazi University
Duchene Muscular Dystrophy
A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy
This is a prospective observational study conducted to evaluate safety, tolerability, and functional outcomes of patients with DMD newly initiating oral givinostat or having started therapy within 6 months as part of routine…
- Trial name
- PROVIDUS (NCT07127978)
- Where
- 9 sites in United States
- Volunteers
- 300 people
- Sponsor
- ITF Therapeutics LLC
Cerebral Palsy
Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles
The aim of the study is to confirm the functional improvement obtained through treatment of spasticity on 2 agonist and antagonist muscles.
- Trial name
- NCT00133861
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Prader-Willi Syndrome, Obesity
Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Willi Syndrome
Context: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.
- Trial name
- NCT01479322
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Carpal Tunnel Syndrome
Efficacy of Dry Needling With the Fascial Winding Technique in the Carpal Tunnel Syndrome
So far there are studies that report the benefits of physiotherapy treatment in carpal tunnel syndrome, but none on the treatment of dry needling.
- Trial name
- NCT03907956
- Testing
- Dry Needling with Fascial Winding Technique
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Universitat Internacional de Catalunya
Temporomandibular Joint Disorders, Temporomandibular Joint Disc Displacement, Without Reduction
Physical Therapy for Temporomandibular Joint (TMJ) Closed Lock
The aim of the present study was to investigate the effect of Physical Therapy (PT) on pain and mandibular function in patients with anterior disc displacement without reduction (ADD-R) or "closed lock" of the TMJ and this in a…
- Trial name
- NCT01475630
- Testing
- physical therapy, control
- Where
- Belgium
- Volunteers
- 49 people
- Sponsor
- KU Leuven
Fibromyalgia, Sexual Dysfunction
Fibromyalgia and Sexual Functıonal Dısorder and Sexual Therapy
investigators aim to re-evaluate the findings of Fibromyalgia in patients whose FSFI scores return to normal levels after sexual therapy, by identifying patients with sexual dysfunction according to the FSFI scale applied in…
- Trial name
- NCT05272345
- Testing
- sexual therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
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