Clinical trials: Muscle Spasticity, open to volunteers
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Cerebral Palsy, Cerebral Palsy, Spastic
Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy
Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations.
- Trial name
- HABIT-ILE (NCT07253857)
- Testing
- GROUP -A , Hand and Arm Bimanual Intensive Therapy Including Lower Extremity, GROUP-B , Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Dystonic Cerebral Palsy
Intrathecal Baclofen and Pediatric Dystonia
The goal of this study is to better understand outcomes in children with dystonic cerebral palsy (CP) receiving intrathecal baclofen (ITB), ventral dorsal rhizotomy (VDR), or deep brain stimulation (DBS) as part of standard…
- Trial name
- PREDICT-ITB (NCT06606574)
- Testing
- ITB Titration Protocol, Ventral Dorsal Rhizotomy, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor College of Medicine
Hemiparesis, Paraparesis
Immediate Effects On Gait and Spasticity After The Use Of Passive Kinesiotherapy Equipment In The Lower Limbs Of Neurological Patients
Undergo assessment of muscle tone (Ashworth Scale), gait (BAIOBIT) and risk of falling (Timed Up and Go) before using the device; Use the device on the spastic lower limb(s) for 30 minutes; Go through the same assessment carried…
- Conditions
- Hemiparesis, Paraparesis, Tetraparesis, Cerebral Palsy
- Trial name
- NCT06696040
- Testing
- Passive mobilization using a device
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Fernanda Trubian
Cerebral Palsy (CP), Unilateral Cerebral Palsy
tDCS and Bi-manual Training in Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function.
- Conditions
- Cerebral Palsy (CP), Unilateral Cerebral Palsy, Spastic Cerebral Palsy (sCP)
- Trial name
- NCT07573865
- Testing
- Anodal tDCS
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
Spastic Cerebral Palsy (sCP)
Talocrural Mobilization With Movement in Spastic Cerebral Palsy
The aim of this randomized controlled trial is to find the effect of Mulligan's Mobilization with Movement of Talocrural joint in Cerebral Palsy Patients having spasticity on improving Ankle Range of Motion, improving balance and…
- Trial name
- NCT06598657
- Testing
- Mobilization with Movement MWM, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Cerebral Palsy Spastic Diplegia
Effect of Blood Flow Restriction With Aerobic Training on Chest Muscles in Diaplegic Cerebral Palsy
To evaluate the effect of blood flow restriction combined with aerobic training on chest muscle strength in individual with diaplegic cerebral palsy
- Trial name
- NCT07072533
- Testing
- blood flow restriction training
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cerebral Palsy, Spastic
Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy
This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy
- Trial name
- NCT06494618
- Testing
- Radial Extracorporeal Shockwave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medeniyet University
Spastic Cerebral Palsy, Acquired Brain Injury
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP).
- Trial name
- 3D-MMAP (NCT05197764)
- Where
- Belgium
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy
Pully System Exercise Role in Management of Spasticity
The goal of this clinical trial is to investigate the effect of pully system exercise in in management of spasticity in cerebral palsy children Does pully system exercise has role in management of spasticity in cerebral palsy…
- Trial name
- NCT06927869
- Testing
- designed physical therapy , pully system exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Spasticity, Muscle
Effect of Treatment Dairy for Spasticity
1. Assessing whether the treatment diary can help optimize the overall treatment of patients. 2. To assess whether the patient finds the treatment diary useful and worth spending time on.
- Trial name
- NCT03384927
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Flat Foot; Spastic
To Evaluate the Efficiency and Results of Adding BFR to the Physical Therapy Program fo Managing Adolescents Presented With Spasmotic Flatfoot Deformities Compared to the Standard Physical Therapy Program Without BFR
The goal of this randomized clinical trial is to evaluate the efficiency and results of adding blood flow restriction (BFR) training to the physical therapy program for managing adolescents presented with spasmotic flatfoot…
- Trial name
- BFR SFFD (NCT07343752)
- Testing
- blood flow restriction
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia
Natural History Study of Patients with HPDL Mutations
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
- Conditions
- Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia, Spastic Paraplegia, White Matter Disease
- Trial name
- NCT05848271
- Testing
- Patient Registry, Dry blood spots sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Encephalopathy, Psychosis
Neuroimmunology Registry and Biobank
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases.
- Conditions
- Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy
- Trial name
- NCT06958341
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
CP (Cerebral Palsy)
rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT
This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy.
- Trial name
- NCT06128746
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Paraparesis, Gait Disorders, Neurologic
Effect of Electromagnetic Field Therapy on Balance and Gait in Paraparetic Patients
This study will investigate whether adding electromagnetic field therapy (EMT) to a standard physical therapy program is more effective than physical therapy alone for improving balance and walking ability in paraparetic…
- Conditions
- Paraparesis, Gait Disorders, Neurologic, Postural Balance Disorders
- Trial name
- EMT-BG (NCT07196956)
- Testing
- Low-Frequency Electromagnetic Field Therapy (0.5 Hz)
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- MTI University
Cerebral Palsy Infantile, Upper Limb Spasticity
Peripheral Neurotomies of the Upper Limb in Children With Cerebral Palsy.
Cerebral palsy (CP) is the leading cause of neurological disability in children, with a prevalence of 2-2.5 per 1,000 live births in Europe.
- Trial name
- PN-ULCP (NCT07915466)
- Testing
- Peripheral neurotomy of the upper limb (musculocutaneous and/or median and/or ulnar).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Idiopathic Toe Walking, Cerebral Palsy
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk.
- Conditions
- Idiopathic Toe Walking, Cerebral Palsy, Hereditary Spastic Paraparesis, Traumatic Brain Injury
- Trial name
- Plantaris Sx (NCT07090057)
- Testing
- Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Cerebral Palsy (CP), Spasticity
Predictors of Motor İmagery Performance in Cerebral Palsy
There are very few studies in the literature examining the effect of age on motor imagery ability in children with cerebral palsy. To our knowledge, no studies have investigated the impact of other related factors.
- Conditions
- Cerebral Palsy (CP), Spasticity, Motor Learning
- Trial name
- NCT07002567
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University