Clinical trials: Muscular Weakness
Duchenne Muscular Dystrophy, Lower Urinary Tract Symptoms
Examination of Lower Urinary System Symptoms With Duchenne Muscular Dystrophy
The aim of this study is to examine the prevalence of lower urinary tract symptoms (LUTS) in children with Duchenne Muscular Dystrophy (DMD) and the relationship between functional level, posture, muscle strength, pelvic floor…
- Conditions
- Duchenne Muscular Dystrophy, Lower Urinary Tract Symptoms, Muscle Weakness, Posture Disorders in Children
- Trial name
- NCT05464446
- Testing
- Baseline Bubble Inclinometer, Baseline Digital İnclinometer and Hoggan microFET2 devices
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Lokman Hekim University
Muscle Weakness
Electromyography in Patients on Chronic Pyridostigmine Therapy
We intend to measure evoked EMG at two sites in subjects who are chronically taking pyridostigmine.
- Trial name
- NCT02364180
- Testing
- Electromyography (EMG)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Toledo Health Science Campus
Andersen-Tawil Syndrome, Andersen Syndrome
Characteristics of Andersen-Tawil Syndrome
Andersen-Tawil Syndrome (ATS) is a rare, genetic disorder that causes episodes of muscle weakness, potentially life-threatening changes in heart rhythm, and developmental abnormalities.
- Trial name
- NCT00521794
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 28 people
- Sponsor
- University of Rochester
Meniscectomy
Muscle Weakness and Post-traumatic Knee OA
This is a single-center, randomized, single-blind (evaluator) study. Enrolled patients had a traumatic meniscal tear and underwent meniscectomy.
- Trial name
- NCT01879852
- Testing
- Quadriceps intensive strengthening, Standard rehabilitation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Muscle Weakness, Sports Performance
Light Therapy and Electrical Stimulation on Functional Performance in Volleyball Athletes
Background: Volleyball players constantly perform vertical jumps, the higher the height of the jump is better sports performance of these players. Several methods have been tested to improve jumping performance in these players.
- Trial name
- NCT02443701
- Testing
- Exercise, LASER, NMES
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centro de Traumatologia do Esporte
Weak; Pelvic Floor, Weak; Muscle
Effect of the Pelvic Floor Training in Postmenopausal Women With or Without Hormonal Therapy
The purpose of this study is to evaluate the effect of pelvic floor muscle training (PFMT) on muscle function of postmenopausal women using or not using hormonal therapy replacement (HTR).
- Conditions
- Weak; Pelvic Floor, Weak; Muscle, Urinary Incontinence
- Trial name
- NCT02549729
- Testing
- pelvic floor muscle training
- Where
- Brazil
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cerebral Palsy, Muscle Hypertonia
Hypertonia in Patients With Cerebral Palsy
This study will classify types of hypertonia in patients with cerebral palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension.
- Trial name
- NCT00123708
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pediatric Burns, Burn Injury
Plyometrics for Strength and Function After Pediatric Burns
Pediatric burn survivors may experience persistent deficits in lower-limb strength, explosive power, and functional performance after hospital discharge.
- Conditions
- Pediatric Burns, Burn Injury, Post-Burn Rehabilitation, Rehabilitation
- Trial name
- NCT07590557
- Testing
- Plyometric Training, Standard Exercise Program
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- Qassim University
Anterior Cruciate Ligament Injuries, Muscle Weakness
Changes in the Force-velocity Relationship of Knee Muscles After ACL Reconstruction
Anterior cruciate ligament (ACL) tear is a frequent and devastating injury in sport, especially in pivoting-contact disciplines.
- Trial name
- FoVeA (NCT05712109)
- Testing
- Follow-up after Anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
Cerebral Palsy, Weakness
Use of Surface Electromyography Biofeedback to Improve Reaching in Children With Cerebral Palsy
A newly-developed device for biofeedback of surface EMG will be used to either increase or decrease activity in the muscles of children with poor reaching due to cerebral palsy.
- Conditions
- Cerebral Palsy, Weakness, Hypertonia
- Trial name
- NCT00473161
- Testing
- surface EMG biofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Leg Pain, Peripheral Nerve Discontinuities
Effect of Nerve Stimulation on Sciatic Nerve Injury Pediatric Patients
Brief Summary The goal of this study is to learn if Faradic Nerve Stimulation (FNS) can help children recover from a condition called Post-Injection Sciatic Nerve Injury (PISNI).
- Conditions
- Leg Pain, Peripheral Nerve Discontinuities, Muscle Weakness, Sciatic Nerve Compression
- Trial name
- PISNI (NCT06781060)
- Testing
- Faradic Nerve Stimulation Therapy+Standard Physiotherapy, Physiotherapy Standard Treatment with TENS machine therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Azeem Hospital, Multan
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Sugammadex Reversal Time, Muscle Weakness
The Effect of Methylprednisolone on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group
The aim of this study is to thoroughly investigate the interaction between methylprednisolone and sugammadex in the pediatric patient population.
- Trial name
- NCT06623370
- Testing
- methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Increased Lordosis/Scoliosis, Hyporeflexia
Biomarker for Duchenne Muscular Dystrophy
International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.
- Conditions
- Increased Lordosis/Scoliosis, Hyporeflexia, Duchenne Muscular Dystrophy, Red-Green Color Blindness
- Trial name
- BioDuchenne (NCT02994030)
- Where
- 12 sites in Albania, Egypt and 6 more
- Volunteers
- 103 people
- Sponsor
- CENTOGENE GmbH Rostock
COPD
Does Muscle Wasting Always Mean Muscle Weakness? A Prevalence Study in COPD
Peripheral muscle mass and strength are relevant indicators of COPD survival. Current guidelines recommend to assess muscle strength only in muscle wasted patients.
- Trial name
- M2W (NCT02080936)
- Where
- France
- Volunteers
- 138 people
- Sponsor
- 5 Santé
Muscle Weakness, Late Effect of Burn
Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients
This study will measure efficacy of early in-patient exercise as an adjunct to current Standard of Care (SOC) for 96 patients in a multi-centre trial.
- Conditions
- Muscle Weakness, Late Effect of Burn, Muscle; Fatigue, Heart, Burn Rehabilitation
- Trial name
- MP-10 (NCT02739464)
- Testing
- Exercise + SOC PT/OT, SOC PT/OT
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Muscle Weakness, Problems Moving Their Arms and Legs
Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults
People with cerebral palsy (CP), muscular dystrophy (MD), spina bifida, or spinal cord injury often have muscle weakness, and problems moving their arms and legs.
- Trial name
- NCT06998134
- Testing
- Extension assist knee ankle foot orthosis (EA-KAFO)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Duchenne Muscular Dystrophy With Mutations Amenable to PBGENE-DMD
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
The purpose of this Phase 1/2a trial is to evaluate the safety, tolerability, and preliminary efficacy of PBGENE-DMD in patients with DMD harboring mutations amenable to excision of exons 45-55.
- Trial name
- NCT07429240
- Testing
- PBGENE-DMD (IV)
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Precision BioSciences, Inc.
ICU Acquired Weakness, Weaning Failure
Predictors of Prognosis in Patients With Critical Illness.
Recently, intensive care unit acquired weakness (ICUAW) has become a hotspot issue in the patients with critical illness. The symptoms of ICUAW, including sensory impairment and muscle atrophy, may lead to poor quality of life…
- Conditions
- ICU Acquired Weakness, Weaning Failure, Quality of Life
- Trial name
- NCT04914065
- Testing
- Regular care in the surgery intensive care unit
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taoyuan General Hospital
Covid19, COVID-19 Respiratory Infection
Post COVID-19 Pulmonary Rehabilitation Program
Coronavirus-2019 disease (COVID-19) is a highly infectious respiratory disease that causes respiratory, physical and psychological dysfunction in patients.
- Conditions
- Covid19, COVID-19 Respiratory Infection, Lung Diseases, Respiratory Insufficiency
- Trial name
- COVID19REHAB (NCT04982042)
- Testing
- Pulmonary Rehabilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Centro Universitário de Anapolis