Clinical trials: Musculoskeletal Disease
Juvenile Rheumatoid Arthritis
Infliximab to Treat Children With Juvenile Rheumatoid Arthritis
This study will determine whether a stepwise increase of the drug infliximab (Remicade® (Registered Trademark)) controls juvenile rheumatoid arthritis more effectively than a fixed dose.
- Trial name
- NCT00029042
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Scar, Contracture
Perforator Artery Changes During Suprafascial Pre-expansion of the Perforator Flaps
Tissue expansion methods have been recommended as a means of improving the clinical results with perforator flaps but in plastic surgery literature there are few clinical trials supporting this opinion.
- Conditions
- Scar, Contracture, Flap Disorder
- Trial name
- NCT01777386
- Testing
- preexpanded perforator flap surgery
- Volunteers
- 14 people
- Sponsor
- Istanbul University
MELAS Syndrome
Nitric Oxide Production in MELAS Syndrome
Introduction Baylor College of Medicine and Texas Children's Hospital are recruiting individuals with MELAS syndrome for a clinical study.
- Trial name
- NCT01339494
- Testing
- Arginine and citrulline supplementations
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Knee Osteoarthritis
Effectiveness of Using a Chatbot to Promote Adherence to Home Physiotherapy
A Chatbot oriented to virtually assist patients in a physiotherapy treatment has been designed and developed to interact with patients with musculoskeletal disorders in need for domiciliary rehabilitation.
- Trial name
- NCT05363137
- Testing
- Chatbot Assistant, Standard care
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- University of Valencia
Knee Osteoarthritis
Is Isokinetic Testing an Indicator of Total Knee Arthroplasty
In this study, investigators analyzed whether the isokinetic knee muscle strength of patients undergoing unilateral total knee arthroplasty (TKA) is a predictor for surgery.
- Trial name
- NCT05668546
- Testing
- isokinetic testing CSMI HUMAC NORM instrument
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Bahçeşehir University
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Juvenile Idiopathic Arthritis
Effect of Whole Body Vibration Therapy in Children With Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is one of the most common chronic illnesses in children, with recent data suggesting that 1 to 4 in 1000 Canadian children and youth cope with the condition.
- Trial name
- WBV-JIA (NCT00836394)
- Testing
- Galileo (whole body vibration (WBV) therapy)
- Where
- Canada
- Sponsor
- Children's Hospital of Eastern Ontario
Shoulder Impingement Syndrome, Adhesive Capsulitis
Sayed Issa's Hybrid Shoulder Arthroscopic-Open Surgical Management (HSSM)
Sayed Issa's Hybrid Shoulder Arthroscopic-Open Surgical Management (HSSM) is a limited lateral approach to the shoulder arthroscopically guided.
- Conditions
- Shoulder Impingement Syndrome, Adhesive Capsulitis, Rotator Cuff Tear, Hill-Sachs Lesion
- Trial name
- HLSSM (NCT05897866)
- Testing
- Sayed Issa's Hybrid Shoulder Arthroscopic-Open Surgical Management
- Where
- Syria
- Volunteers
- 44 people
- Sponsor
- Issa, Abdulhamid Sayed, M.D.
Primary Sjögren's Syndrome
Study of Pharmacodynamic Effects of VAY736 in Patients With Primary Sjögren's Syndrome
This study consists of three consecutive parts. Part 1 in primary Sjögren's syndrome (pSS) patients (n=2-6) and Part 2 in healthy voluteers (n=3) are feasibility studies to assess if the selected [Zr-89]-rituximab PET/CT method…
- Trial name
- NCT02495129
- Testing
- VAY736 lower dose, VAY736 higher dose
- Sponsor
- Novartis Pharmaceuticals
Scoliosis
Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine
Reduction of the spinal cord injuries during scoliosis surgery is a major goal of the anesthesia and surgical team. Despite improvement in scoliosis surgery over the years, the development of neurological deficits remains the…
- Trial name
- NCT00671931
- Testing
- low dexmedetomidine, low propofol, high dexmedetomidine, low propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Developmental Dysplasia of the Hip
Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH
This study evaluates the feasibility and utility of contrast-enhanced ultrasound to provide real-time assessment of blood flow to the femoral head in infants undergoing surgical reduction for developmental dysplasia of the hip.
- Trial name
- NCT03107520
- Testing
- Intraoperative contrast-enhanced ultrasound (CEUS), Lumason
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Philadelphia
Osteoarthritis
Lateral Wedge Insole With Subtalar Strapping for Knee Osteoarthritis
This is a clinical study to evaluate the efficacy of a lateral wedge insole with subtalar strapping in knee osteoarthritis treatment.
- Trial name
- NCT01739296
- Testing
- Lateral wedge insole with subtalar strapping
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Osteoporosis, Treatment Failure
Incidence of the Treatment faIlure in Osteoporosis
Osteoporotic fractures are associated with significant morbidity, increased mortality and reduction in the quality of life, available treatments reduces the fracture risk between 30 and 70%, however some patients experience a new…
- Trial name
- TAILOR (NCT05499403)
- Where
- Switzerland
- Volunteers
- 415 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Duchenne Muscular Dystrophy, Duchenne Disease
Vasodilator and Exercise Study for DMD (VASO-REx)
Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved…
- Conditions
- Duchenne Muscular Dystrophy, Duchenne Disease, Muscular Dystrophy, Muscular Dystrophy in Children
- Trial name
- NCT06290713
- Testing
- Tadalafil, Exercise Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Cardiac Magnetic Resonance in Children With Muscular Dystrophy
This protocol will exploit novel state of the art cardiovascular magnetic resonance techniques to examine important changes in the heart in children with muscular dystrophy.
- Conditions
- Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Limb Girdle Muscular Dystrophy
- Trial name
- NCT01081080
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Cooperative International Neuromuscular Research Group
Acute Lymphoblastic Leukemia, Nephrotic Syndrome
Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study
To determine the magnitude and rate of bone mass deficits following initiation of glucocorticoid therapy for the treatment of pediatric leukemia, rheumatic conditions and nephrotic syndrome, we propose a 6 year, prospective study…
- Conditions
- Acute Lymphoblastic Leukemia, Nephrotic Syndrome, Rheumatism
- Trial name
- STOPP-CIS (NCT01663129)
- Where
- 12 sites in Canada
- Volunteers
- 406 people
- Sponsor
- Children's Hospital of Eastern Ontario
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Class II Malocclusion, Mandibular Deficiency
Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II
Objective: to evaluate the dentoskeletal effects of CAD/CAM 3D-Printed fixed twin block versus MARA appliances in the management of skeletal class II due to Mandibular Deficiency in Preadolescence Class II malocclusion is…
- Trial name
- NCT07340242
- Testing
- MARA appliance, fixed twin block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Mitochondrial Myopathies, Mitochondrial Diseases
Applying pGz in Mitochondrial Disease
This is a multi-aim study, studying the effects of conventional exercise (measured through Cardiopulomary Exercises Testing or an in-bed pedal exercise) and passive exercise through periodic acceleration (pGz).
- Trial name
- NCT05569122
- Testing
- Cardiopulmonary Exercise Testing, pGz Bed, Gentle Jogger
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Achondroplasia
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
The intent and design of this Phase 3 study is to assess BMN 111 as a therapeutic option for the treatment of children with Achondroplasia
- Trial name
- NCT03424018
- Testing
- BMN 111
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 119 people
- Sponsor
- BioMarin Pharmaceutical
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