Clinical trials: Musculoskeletal Function
Flatfoot, Flexible
The Effect of Insoles on Functional Performance in Pediatric Flexible Flatfoot
Flexible flatfoot is a condition that increase the load of the foot structure.With prolonged standing or walking, some children with flatfoot experience rapid discomfort or fatigue in the foot In this study, the investigators…
- Trial name
- NCT05533762
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Spinal Muscular Atrophy
Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Risdiplam
This was a Phase IIIb open-label, single arm, multi-center study to evaluate the safety, tolerability and efficacy of OAV101B in participants with SMA aged 2 to <18 years after the discontinuation of treatment with nusinersen or…
- Trial name
- STRENGTH (NCT05386680)
- Testing
- OAV101
- Where
- 13 sites in United States, Australia and 7 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Post-COVID-19
The Effects of Video-based Yoga Interventions for Patients With Post-corona Virus Disease
Aimed to understand if yoga exercises are superior to posture exercises as an alternative exercise therapy for relieving musculoskeletal pain, improving functional status, and improving quality of life during the post- corona…
- Trial name
- Yoga (NCT05374668)
- Testing
- Video-based Yoga Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Istinye University
Arthrogryposis Multiplex Congenita, Piezo2 Mutation Gain of Function
Piezo2-related Arthrogryposis & physiopathOLOgy 3
Study type: Observational, non-interventional, single-center, descriptive study. Goal of the study: The goal of this observational study is to characterize the intensity, variability, and qualitative features of pain in patients…
- Trial name
- PAOLO3 (NCT07360574)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Neuromuscular Control, Balance
Acute Impact of Static, Dynamic, and Proprioceptive Exercises on Proprioception, Strength, Balance, and Explosive Power
The purpose of this randomized controlled trial is to compare the acute effects of static stretching, dynamic stretching, and proprioceptive exercises on proprioception, muscle strength, balance, and explosive power in young…
- Conditions
- Neuromuscular Control, Balance, Musculoskeletal Function
- Trial name
- SSDSPE-RCT (NCT07320027)
- Testing
- Static Stretching Exercise Group, Dynamic Stretching Exercise Group, Proprioceptive Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Fibromyalgia
Progressive Resistance Training for Fibromyalgia
Patients in the experimental group underwent a progressive resistance training program, performed twice a week for 12 weeks. The charge intensity was progressively increased from 40% to 80% of 1 repetition maximum.
- Trial name
- NCT03588208
- Testing
- Progressive resistance training program, Educational Program
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Obesity, Childhood
The Effects of Strength and Balance Training on Physical Function in Overweight Children
This intervention study aims to examine the efficacy of a school-based exercise programme to improve strength and balance in overweight and obese 7-11-year-olds in the United Kingdom.
- Trial name
- NCT05665621
- Testing
- Eight-week in-school strength and balance training program
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Cerebral Palsy, Bone Density, Low
Relation Between Bone Mineral Density, Gross Motor Function and Quality of Life In Children With Cerebral Palsy
studying the relationship between Bone Mineral Density, Gross Motor Function and, Quality of Life with CP can provide valuable insights into the musculoskeletal consequences of motor impairments and guide interventions to improve…
- Conditions
- Cerebral Palsy, Bone Density, Low, Gross Motor Development Delay
- Trial name
- NCT06180395
- Testing
- Group 1, Group 2
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Duchenne Muscular Dystrophy (DMD)
A Phase III Double-blind Study With Idebenone in Patients With Duchenne Muscular Dystrophy (DMD) Taking Glucocorticoid Steroids
The purpose of the study is to assess the efficacy of idebenone in delaying the loss of respiratory function in patients with DMD receiving concomitant glucocorticoid steroids
- Trial name
- SIDEROS (NCT02814019)
- Testing
- Idebenone 150 mg film-coated tablets
- Where
- 63 sites in United States, Austria and 13 more
- Volunteers
- 255 people
- Sponsor
- Santhera Pharmaceuticals
Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity
Functional and Structural Outcomes Following Childhood Bone or Soft Tissue Sarcomas of the Lower Extremity
Soft tissue and bone sarcomas of the lower extremity pose significant challenges for affected individuals, often associated with considerable burden.
- Conditions
- Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity, Childhood and Adolescent Cancer
- Trial name
- FOCUS (NCT06737172)
- Where
- 2 sites in Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Haemophilia
Multidisciplinary Evaluation of Patients With Hemophilia
Multidisciplinary assessment of the physical, functional and psychosocial alterations in patients with hemophilia around the country.
- Trial name
- HOLISTIC (NCT02198430)
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Universidad de Murcia
Distal Femoral Musculoskeletal Tumors
Functional Outcomes and Quality of Life in Musculoskeletal Tumor Patients With Distal Femoral Megaprostheses
This study aims to evaluate the functional outcomes of patients with distal femur tumor prostheses in comparison to a matched control group.
- Trial name
- FOQ-DFP (NCT06282198)
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Brain Tumor, Brain Cancer
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
This is a prospective, observational clinical trial investigating the morphological and volumetric changes in the brain following cranial Radiation Therapy in pediatric patients with brain or skull base tumors.
- Conditions
- Brain Tumor, Brain Cancer, Skull Base Tumor
- Trial name
- NCT03972514
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baptist Health South Florida
Cerebral Palsy.
Exploring Hypertonia in Children With Cerebral Palsy
Abnormal limb and trunk movements are seen in many children with cerebral palsy. Recognizing the difference between types of these movements is not well understood.
- Trial name
- HypE-CP (NCT01744158)
- Testing
- No intervention applicable
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Women's and Children's Hospital, Australia
Mucopolysaccharidosis IV Type A, Morquio A Syndrome
Non-invasive Functional Assessment and Pathogenesis of Morquio A
Morquio A disease is a devastating systemic skeletal disease in which detailed progression and pathogenesis remain unknown. The proposed project aims to establish a non-invasive objective assessment that can be applicable to all…
- Conditions
- Mucopolysaccharidosis IV Type A, Morquio A Syndrome, MPS IVA
- Trial name
- NIFAMA (NCT05284006)
- Testing
- Imaging, gait analysis, growth, joint test, hearing test, questionnaire, etc.
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Nemours Children's Clinic
Duchenne Muscular Dystrophy (DMD)
Research on the Relationship Between Scoliosis, Pain, Quality of Life, and Trunk Muscle Compensation Patterns Among Patients with Duchenne Muscular Dystrophy.
Objective: The objective of this observational study is to evaluate and quantify trunk muscle compensatory movement patterns in patients with Duchenne Muscular Dystrophy (DMD) using computer vision technology.
- Trial name
- NCT06755138
- Testing
- Observational Assessment
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Metabolic Myopathies, Exercise Test
Metabolic Exercise Testing
Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected.
- Conditions
- Metabolic Myopathies, Exercise Test, Myalgia
- Trial name
- RANNOU (NCT02362685)
- Testing
- functional test, matching genotype with phenotype
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Hemophilia
Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia
Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia. Describe the periarticular muscular deficit of the lower limbs, depending on the degree of injury: acute and chronic, or…
- Trial name
- HE-BALANCE (NCT02165592)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Cerebral Palsy, Anxiety
Does Anxiety Affect Balance, Spasticity and Function in Children With Cerebral Palsy
children and adolescents with CP are at increased risk of developing mental health difficulties, particularly anxiety disorders, compared with their typically developing peers.
- Conditions
- Cerebral Palsy, Anxiety, Spasticity
- Trial name
- NCT07346430
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cleft Lip and Palate, Maxillary Hypoplasia
Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Cleft lip and palate patients normally present with a sunken face due to collapse in the middle part of the face and inability of the upper and lower teeth to meet during chewing.
- Trial name
- NCT00930124
- Testing
- Orthognathic surgery, Distraction osteogenesis
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong