Clinical trials: Musculoskeletal Function
Cerebral Palsy (CP), Hand Grip Strength
Effects Of Spiral Strapping Systems On Upper Limb Function In Unilateral Spastic Cerebral Palsy
The purpose of this clinical study is to learn whether two different spiral strapping systems can improve arm and hand use in children with unilateral spastic cerebral palsy.
- Conditions
- Cerebral Palsy (CP), Hand Grip Strength, Upper Extremity Function, Spasticity
- Trial name
- NCT07418710
- Testing
- TheraTogs® Spiral Strapping System, TogRite™ Spiral Strapping System, Upper Limb Rehabilitation and Home Exercise Program
- Volunteers
- 27 people
- Sponsor
- Abant Izzet Baysal University
Duchenne Muscular Dystrophy
Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD
This study is a longitudinal, randomized control trial evaluating the use of two commercially available dynamic arm support devices (1) Armon Ayura-Kinova and 2) JAECO WREX) to promote participation in activities of daily living…
- Trial name
- NCT03531788
- Testing
- Armon Ayura (Kinova), JAECO Wrex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roxanna Marie Bendixen
Temporomandibular Joint Disorder
Effect of Functional Treatment on Mandibular Asymmetric Growth
Temporomandibular joint (TMJ) arthritis is known to alter the mandibular development in children diagnosed with juvenile idiopathic arthritis.
- Trial name
- NCT01113177
- Testing
- Distraction splint therapy
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Cleft Palate
Middle Ear Pressure Disregulation in Cleft Palate Patients
The investigators know that middle-ear disease is very common in infants with cleft palate and causes hearing loss that can last into childhood.
- Trial name
- NCT00423072
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Pittsburgh
Degenerative Disc Disease, Degenerative Spondylolisthesis
The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy
The five-repetition sit-to-stand test (5R-STS) has been used in many medical disciplines, but has never been correlated with or validated in regard to degenerative spinal diseases.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Herniated Disc, Stenosis, Spinal
- Trial name
- 5R-STS (NCT03303300)
- Where
- Netherlands
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Marc Schröder
Cleft Lip and Cleft Palate, Cleft Lip Palate
Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.
The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills.
- Conditions
- Cleft Lip and Cleft Palate, Cleft Lip Palate, Cleft Lip and/or Palate, Cleft Palate
- Trial name
- NCT07219901
- Testing
- Early intervention for language, articulation and palatal function skills
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Old Dominion University
Spastic Cerebral Palsy (sCP)
Biomechanical and Functional Effects of Adding Sensory-Threshold Electrical Stimulation to Neurodevelopmental Therapy in Children With Spastic Cerebral Palsy: A Single-Arm Repeated-Measures Study
This study investigates whether adding sensory-level electrical stimulation to an ongoing neurodevelopmental treatment program is associated with changes in ankle mobility, spasticity-related measures, muscle mechanical…
- Trial name
- NCT07491341
- Testing
- Sensory Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Harran University
Obesity
Whole Body Vibration Effects on Energy Expenditure in Obese Adolescents
The main aim of the present study is to evaluate in a group of adolescents with obesity, hospitalized for a period of integrated metabolic rehabilitation (calorie restriction, aerobic physical activity, psychological counseling…
- Trial name
- VIBRAREEOB (NCT06800872)
- Testing
- Multidisciplinary metabolic rehabilitation, Multidisciplinary metabolic rehabilitation + training with WBVE
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Istituto Auxologico Italiano
Growth Hormone Deficiency
Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD)
The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of…
- Trial name
- GHD (NCT02507245)
- Testing
- Growth Hormone-Releasing Hormone
- Volunteers
- 48 people
- Sponsor
- Stefania La Grutta, MD
Bone Neoplasm, Rehabilitation
Functional Recovery of Patients Undergoing Resection and Reconstruction of the Lower Limbs for Bone Tumor.
The aim of the present study is to describe the course of functional recovery of patients with musculoskeletal tumours and undergone resection and reconstruction operations of lower limbs in the first six months post-surgery…
- Trial name
- FISIO-ONCO (NCT06376539)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Orthodontic Appliance Design, Retrognathism
Effect of the Innovated Seifi's Functional Appliance on Skeletal and Dentoalveolar Changes of Class II/ 1, Deep Bite
For improving the appearance of protruded upper front teeth when lower front teeth may touch palatal mucosa or have proximity to that; the innovated Seifi's Functional Appliance may be used.
- Conditions
- Orthodontic Appliance Design, Retrognathism, Malocclusion, Angle Class II, Deepbite
- Trial name
- Seifi-Fx (NCT00688233)
- Testing
- Seifi's Functional
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Motor Function, Gait
Spinal Cord Stimulation Therapy for Hereditary Spastic Paraplegias Patients
It's a single-center, prospective, open label clinical study with a 12 months follow-up period, to investigate the therapeutic effect and safety of spinal cord stimulation (SCS) on motor function and gait in patients with pure…
- Trial name
- NCT05196178
- Testing
- Spinal cord stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Xuanwu Hospital, Beijing
Dwarfism, Turner's Syndrome
The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical changes normally associated…
- Trial name
- NCT00001343
- Testing
- Humatrope, Oxandrolone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Muscular Dystrophy, Duchenne, Upper Extremity
The Effects of Trunk Exercises on Upper Extremity and Respiratory Functions in DMD
The aim of this study was to investigate the effects of trunk training on trunk control, upper extremity, and pulmonary function in children with Duchenne muscular dystrophy (DMD).
- Conditions
- Muscular Dystrophy, Duchenne, Upper Extremity, Respiratory Functions
- Trial name
- NCT04669847
- Testing
- Trunk-oriented exercise program, Conventional exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gokce Yagmur Gunes Gencer
Hypochondroplasia
An Interventional Study of Infigratinib in Children With Hypochondroplasia
ACCEL2/3 is a Phase 2/3 study. The purpose of the Phase 2 portion of the study (ACCEL2/3) is to evaluate the efficacy and safety of infigratinib in children with hypochondroplasia (HCH) receiving infigratinib at one of two doses…
- Trial name
- HCH (NCT06873035)
- Testing
- infigratinib 0.128 mg/kg/day, infigratinib 0.25 mg/kg/day
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Intellectual Disability, Rubinstein-Taybi Syndrome
Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients.
- Conditions
- Intellectual Disability, Rubinstein-Taybi Syndrome, Cystic Fibrosis, Congenital Heart Defect
- Trial name
- RID (NCT05696912)
- Testing
- Ex-vivo approach concerning 25 patients, In-vitro approach concerning 25 patients
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment
Vibration Effects on Gait and Balance in CP
This randomized controlled study aims to investigate the acute effects of local vibration applied to the spastic medial gastrocnemius muscle on balance and spatiotemporal gait parameters in children with hemiparetic cerebral…
- Trial name
- NCT07045519
- Testing
- Local Vibration Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kırıkkale University
Adolescent Idiopathic Scoliosis
Coping After Pediatric Scoliosis Surgery
This is a prospective, randomized controlled trial evaluating the efficacy of expanded patient education and coping skills on pain management following multilevel pediatric spinal surgery.
- Trial name
- CAPS (NCT04063670)
- Testing
- Video Intervention, Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Flexible Flatfoot
Clinical Trial of the Effect of Functional Orthoses in Children With Flat Feet
The purpose of this study is to investigate the efficay of functional plantar orthoses on flatfoot in children.
- Trial name
- NCT02633566
- Testing
- Plantar orthoses
- Volunteers
- 61 people
- Sponsor
- Fresno, Raquel Lopez, M.D.
Patellofemoral Pain Syndrome
Pilates-based Core Strengthening on Patellofemoral Pain Syndrome
Patellofemoral pain syndrome (PFPS) is one of the most common musculoskeletal pain conditions that tend to become a chronic problem.
- Trial name
- Pilates (NCT05120583)
- Testing
- Pilates exercises, Traditional physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- Qassim University