Clinical trials: Musculoskeletal Growth and Development
Zika Virus Infection
Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection
Introduction: It is estimated that more than one million Brazilians were infected by zika virus in the last two years. Brazilian researchers first noted the virus's potential association with microcephaly.
- Trial name
- NCT03679728
- Testing
- First trimester, Second trimester
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Osgood-Schlatter Disease
Rate of Torque Development in Adolescents With Osgood-Schlatter
Osgood-Schlatter is a growth-related condition involving multiple different types of tissue in the tendon-bone interface at the tibial tubercle.
- Trial name
- NCT05789095
- Testing
- Rate of torque development testing of knee flexors and knee extensors using a fixated handheld dynamometer (MicroFet 2, Hoggan, Scientific L.L.C., Salt Lake City, USA), sampling rate of 100hz)
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Achondroplasia
A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia
This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of infigratinib in children and adolescents with achondroplasia (ACH) who have completed at least 26 weeks of…
- Trial name
- PROPEL3 (NCT06164951)
- Testing
- Infigratinib 0.25 mg/kg/day
- Where
- 27 sites in United States, Argentina and 8 more
- Volunteers
- 114 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Child Development, Sensory Disorder
Sensory Processing Skills in Toddler With Joint Hypermobility
shows that children and adults with joint hypermobility may be identified with common clinical problems that are unrelated, such as chronic fatigue, anxiety, and a range of gastrointestinal functional disorders [4-6].
- Conditions
- Child Development, Sensory Disorder, Hypermobility, Joint
- Trial name
- NCT06041191
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Gazi University
Hypogonadism, Precocious Puberty
Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II.
- Trial name
- NCT00004335
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Growth Hormone Deficiency, Dwarfism
rhGH Therapy on Hepatic Drug Metabolism
The purpose of the study is to understand the effect of rhGH therapy on hepatic drug metabolism in children with idiopathic growth hormone deficiency.
- Trial name
- NCT00458991
- Testing
- Dextromethorphan and Caffeine
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Louisville
Pediatric Overweight
Overweight Children - Musculoskeletal Consequences
The purpose was to investigate the consequences of pediatric overweight on the musculoskeletal system, postural control and proprioception, and to analyze prospectively the influence of ball games and nutrition counseling.
- Trial name
- NCT01825174
- Testing
- Ball games program, Nutrition counseling
- Where
- Germany
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Idiopathic Growth Hormone Deficiency, Turner Syndrome
First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study
PREDICT Validation is a validation pharmacogenetic trial. The purpose of this study is to confirm that some genes can be used to predict how well a subject diagnosed with idiopathic growth hormone deficiency (IGHD) or turner…
- Trial name
- NCT01419249
- Testing
- Blood sampling
- Where
- 31 sites in Argentina, Canada and 7 more
- Volunteers
- 458 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Rheumatoid Arthritis, Arthralgia
Survivin as Predictive Biomarker for RA
Purpose: to examine the possibility of using the onco-protein survivin as a predictive biomarker for identifying individuals at risk of developing rheumatoid arthritis within a cohort of patients seeking treatment for joint…
- Conditions
- Rheumatoid Arthritis, Arthralgia, Joint Pain
- Trial name
- SurviPred (NCT03444623)
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Vastra Gotaland Region
Hypochondroplasia
Prospective Clinical Assessment Study in Children With Hypochondroplasia
This is a long-term, multicenter, non-interventional study of children ages 2.5 to <17 years with hypochondroplasia (HCH).
- Trial name
- HCH (NCT06410976)
- Where
- 25 sites in United States, Australia and 8 more
- Volunteers
- 150 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Cockayne Syndrome, Type I and II
Growth Curves in Cockayne Syndrome Type 1 and Type 2
Despite the natural progression of Cockayne's syndrome, affected patients also present with variable neurological and gastrointestinal damage (gastroesophageal reflux, recurrent vomiting, swallowing disorders, etc.) with varying…
- Trial name
- Curves-CS (NCT05090917)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Strasbourg, France
Flatfoot, Flexible, Sports Physical Therapy
Neurophysiology-based Intervention of Foot Dysfunction in Sportive Children
The goal of the clinical trial study is to test the effect of the individual complex physiotherapy intervention program in the children actively playing soccer with flatfoot or valgus foot. The aims are: 1.
- Conditions
- Flatfoot, Flexible, Sports Physical Therapy, Child Development
- Trial name
- NCT05902091
- Testing
- Neurophysiology-based intervention
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Fitness
Fitness Level in Short Stature Children and After Growth Hormone Treatment
fitness and Physical activity will be evaluate in short stature children, using the Euro Fitness testing and the Wingate anaerobic test.
- Trial name
- NCT02977091
- Testing
- change in fitness level
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Pain, Osteoarthritis
Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis
The goal of this prospective study is to identify variables that can predict whether an interdisciplinary biopsychosocial intervention for patients with osteoarthritis will be successful.
- Conditions
- Chronic Pain, Osteoarthritis, Disability Physical
- Trial name
- CIR-predict (NCT05661760)
- Testing
- interdisciplinary multimodal pain treatment
- Where
- Netherlands
- Volunteers
- 2,309 people
- Sponsor
- Maastricht University
Duchenne Muscular Dystrophy, Gait Disorders in Children
Quality and Independence of Gait Classification Scale for DMD (QIGS-DMD)
The aim of this study was to develop a reliable and valid gait classification scale for Duchenne Muscular Dystrophy (QIGS-DMD). The items of the QIGS-DMD were designed based on the literature review considering existing…
- Trial name
- NCT05564962
- Testing
- Quality and Independence of Gait Classification Scale for Duchenne Muscular Dystrophy (QIGS-DMD)
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Hacettepe University
Microcephaly
Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
Screening for microcephaly is important at birth and during early childhood. The Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) aims to establish a multicentric surveillance system for microcephaly in newborns…
- Trial name
- NCT03651687
- Where
- China
- Volunteers
- 47,369 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Megalocephaly
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk
This study will show the value of early genetic diagnosis in the case of MEG in a child and may lead to recommendations aimed at preventing tumor risk based on a simple and easily accessible clinical criterion (the measurement of…
- Trial name
- EMeRiT (NCT07142772)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Growth Hormone Deficiency
Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method
The purpose of this study is to obtain psychological response and user preference information on the use of the T jet® device versus the traditional subcutaneous injection administration of Tev Tropin®.
- Trial name
- T-jet® (NCT00990340)
- Testing
- T-jet® containing TevTropin®, TevTropin® needle-syringe injection method
- Volunteers
- 52 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.