Clinical trials: Musculoskeletal Model
Musculoskeletal Deformity, Musculoskeletal Diseases
Customized Bone Allografts by 3D-printing
Virtual surgical planning (VSP), the simulation of bone corrections in virtual reality ("Computer Aided Surgical Simulation": CASS) and 3D printing of customized implants and devices are achieving an increasingly central role in…
- Conditions
- Musculoskeletal Deformity, Musculoskeletal Diseases, Musculoskeletal Disorder
- Trial name
- 3D-MALF 2 (NCT05700526)
- Testing
- Planning of multiplanar and/or multifocal osteotomies in children by using VSP, PSIs and customized structural bone allograft, Routine preparation of bone graft according to standard protocols, Preparation of bone graft with virtual bone-matching and GSIs
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoporosis, Osteopenia
Models of Primary Osteoporosis Screening in Male Veterans
Models of Osteoporosis Screening in Male Veterans aims to test 1 distinct care model of primary osteoporosis screening in men within the VA healthcare setting.
- Conditions
- Osteoporosis, Osteopenia, Osteoporotic Fracture
- Trial name
- MOPS (NCT04079868)
- Testing
- Bone Health Service Model
- Where
- 3 sites in United States
- Volunteers
- 3,512 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Osteoarthritis
Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis
The goal of this prospective study is to identify variables that can predict whether an interdisciplinary biopsychosocial intervention for patients with osteoarthritis will be successful.
- Conditions
- Chronic Pain, Osteoarthritis, Disability Physical
- Trial name
- CIR-predict (NCT05661760)
- Testing
- interdisciplinary multimodal pain treatment
- Where
- Netherlands
- Volunteers
- 2,309 people
- Sponsor
- Maastricht University
Pierre Robin Sequence (PRS), Difficult Laryngoscopy
3D-CT-Based Prediction of Difficult Laryngoscopy in Infants With Pierre Robin Sequence
This study aims to develop and validate a quantitative prediction model using three-dimensional computed tomography (3D-CT) imaging for identifying infants with Pierre Robin sequence (PRS) at risk of difficult laryngoscopy.
- Conditions
- Pierre Robin Sequence (PRS), Difficult Laryngoscopy, Airway Management
- Trial name
- PRS-3DCT (NCT07257276)
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Nanjing Children's Hospital
Muscle Injury, Pulsed Electromagnetic Therapy
Investıgatıon of The Effıciency of Pulsed Electromagnetıc Field Therapy and Stretching Exercises
In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time.
- Conditions
- Muscle Injury, Pulsed Electromagnetic Therapy, Muscle Stretching Exercise
- Trial name
- NCT05988476
- Testing
- Exercise, Pulsed Electromagnetic Field Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Suleyman Demirel University
Bone Resorption, Diabetes
Application of Information-Motivation-Behavioral Model-based Continuity of Care on the Peri-implantitis Recovery in Diabetic Implant Overdenture Patients
The investigators recruited 32 diabetic IOD patients with a total of 110 problematic implants who had completed the treatment for peri-implantitis between January 2021 and March 2023 as research subjects.
- Trial name
- NCT06103799
- Testing
- IMB model-based continuity of care
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy (DMD)
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
The purpose of this research is (1) to identify disease specific walking-related digital biomarkers of disease severity, and (2) monitor longitudinal changes in natural environments, for extended periods of time, in DMD and SMA.
- Trial name
- NCT06839469
- Where
- 3 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hemophilia A, Hemophilia
Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT®
The purpose of this study is to describe the pharmacokinetic profile of patients with hemophilia A in prophylaxis in Spain using myPKFit®
- Conditions
- Hemophilia A, Hemophilia, Factor VIII Deficiency
- Trial name
- NCT03006965
- Testing
- octocog alfa, rurioctocog alfa pegol
- Where
- 14 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Spanish Society of Thrombosis and Haemostasis
Developmental Dysplasia of the Hip, Acetabular Bone Loss
3D-Printed Pelvic Models for Planning Complex Total Hip Arthroplasty
Total hip arthroplasty (THA) in patients with complex acetabular anatomy can be challenging because of abnormal bone structure, deformity, or bone loss.
- Conditions
- Developmental Dysplasia of the Hip, Acetabular Bone Loss, Acetabular Fracture
- Trial name
- NCT07904637
- Testing
- Conventional Imaging-Based Preoperative Planning, CT-Based 3D-Printed Pelvic Model-Assisted Planning
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Ain Shams University
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy
Wearable Technology to Assess Gait Function in SMA and DMD
The purpose of this project is to devise instrumented insoles capable of accurately measuring gait at each footfall, over multiple hours in any environment.
- Trial name
- NCT04193085
- Testing
- Observational
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acute Kidney Injury, Crush Injury
The Effects of Dexmedetomidine and Remifentanil on Kidney Injury After Muscle Compression Injury in Rats
The goal of this interventional preclinical study is to evaluate the potential protective effects of two intravenous anesthetic agents-dexmedetomidine and remifentanil-on kidney function in the context of muscle crush injury…
- Conditions
- Acute Kidney Injury, Crush Injury, Rhabdomyolysis
- Trial name
- NCT07094165
- Testing
- Dexmedetomidine, Remifentanil, Laparotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara City Hospital Bilkent
Clubfoot
Gait Analysis in Children With Clubfoot Treated With Tibialis Anterior Tendon Transfer
Patients with clubfoot treated with the Ponseti method and undergoing Tibialis Anterior tendon transfer from a prospective database are evaluated using gait analysis including the Oxford foot model and compared to a group of…
- Trial name
- NCT03953430
- Testing
- Gait analysis
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Orthopedic Hospital Vienna Speising
Scoliosis
Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected.
- Trial name
- NCT02434003
- Where
- 9 sites in United States, Canada and 4 more
- Volunteers
- 1,200 people
- Sponsor
- St. Justine's Hospital
Childhood Rheumatic Diseases, Juvenile Idiopathic Arthritis (JIA)
Cognitive Exercise Therapy Approach (BETY) in JIA
Cognitive Exercise Therapy Approach (*Bilişsel Egzersiz Terapi Yaklaşımı*-BETY), an innovative method developed for adults with rheumatism, aims to promote behavioral change and prevent social isolation by focusing on exercises…
- Conditions
- Childhood Rheumatic Diseases, Juvenile Idiopathic Arthritis (JIA), Exercise
- Trial name
- NCT06591949
- Testing
- BETY, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Hacettepe University
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources
Costello Syndrome
Pathophysiology Analysis of "Costello Syndrome" on Cellular Models
The objective is to collect skin biopsies rom patients with Costello syndrome to analyze the molecular mechanisms responsible for this syndrome caused by a mutation in the HRAS gene and the effects of this mutation on energy…
- Trial name
- COSTELLO (NCT02812511)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Growth Hormone Deficiency, Idiopathic Short Stature
Constructing an Insulin-Like Growth Factor-based Prediction Model
Serum insulin-like growth factor-I (IGF-I) measurements have been shown to correlate well with growth hormone action and effect, and recent data show that serum IGF-I may be related to safety and efficacy of growth hormone (GH)…
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Small for Gestational Age
- Trial name
- NCT00263445
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Clubfoot
Gait Analysis in Ponseti Clubfoot
Patients with clubfoot treated with the Ponseti method from a prospective database are evaluated using gait analysis including a foot model and a disease specific instrument score and compared to a group of healthy children.
- Trial name
- NCT02022267
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Orthopedic Hospital Vienna Speising
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato