Clinical trials: NETs
Malaria
Community-Effectiveness of the Distribution of Insecticide-Treated Bed Nets Through Social Marketing Antenatal Care Services in Malaria Control in Rural Burkina Faso
The study aims at assessing which of two distribution channels for insecticide treated bendnets (ITNs), social marketing vs. social marketing coupled with free distribution through ante-natal care, is most effective in reaching…
- Trial name
- NCT00355225
- Testing
- ITN distribution channel
- Sponsor
- Heidelberg University
Malaria, Malaria Vaccine, Insecticide-treated Bednets
RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi
The overall goal of this study is to assess the impact of RTS,S (malaria) vaccination and PBO nets on malaria infection and transmission, independently and how they interact when they are introduced together.
- Trial name
- RTSS/PBO (NCT04327440)
- Testing
- RTS,S/AS01 malaria vaccine, PBO bed nets
- Where
- Malawi
- Volunteers
- 1,691 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Venous Thromboses, Thromboembolic Disease
Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)
Thrombo-embolic venous diseases are represented by deep venous thrombosis and/or pulmonary embolism. In some patients with repeated thrombosis or occurrence of thrombosis in unusual sites, the etiological workup remains negative…
- Conditions
- Venous Thromboses, Thromboembolic Disease, Neutrophil Extracellular Trap Formation, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- CLODETTE (NCT05711173)
- Testing
- Additional blood sampling
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Malaria
LLIN Evaluation in Uganda Project (LLINEUP3)
In Uganda, the National Malaria Control Division (NMCD) and implementing partners are planning to deliver long-lasting insecticidal nets (LLINs) nationwide, through a mass distribution campaign in 2023.
- Trial name
- NCT05950191
- Testing
- long lasting insecticidal nets with chlorfenapyr-pyrethroid (PermaNet Dual), long lasting insecticidal nets with PBO-pyrethroid (PermaNet), Social Behavior Change Communication
- Where
- Uganda
- Volunteers
- 215,903 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pyogenic Infections
NETs Formation in Patients With Recurrent Pyogenic Infections (NETS)
We aim to study if pathological NETs formation could be the underlying pathology among patients with recurrent infections and a normal screening of the immune system.
- Trial name
- NETs (NCT01112592)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Visceral Leishmaniasis, Kala Azar
Efficacy, Acceptability and Cost-effectiveness of Long Lasting Insecticide Nets (LLIN) in the Prevention of Kala Azar
A cluster-randomized vector control trial in Bihar, India, and neighboring Nepal, will test the efficacy of long-lasting impregnated bednets (LLINs, Permanets) for reducing visceral leishmaniasis incidence.
- Trial name
- KALANET (NCT00318721)
- Testing
- Long Lasting Impregnated Nets (LLIN)
- Where
- 2 sites in India, Nepal
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Malnutrition
MAM'Out Project - Evaluation of Multiannual and Seasonal Cash Transfers to Prevent Acute Malnutrition
The MAM'Out research project aims at evaluating a seasonal and multi-annual cash transfer program in the framework of a safety net to prevent acute malnutrition by children under 24 months, in terms of effectiveness and…
- Trial name
- MAM'Out (NCT01866124)
- Testing
- Cash transfer
- Where
- Burkina Faso
- Volunteers
- 1,278 people
- Sponsor
- Action Contre la Faim
Somatostatin Receptor Positive, NETs
Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors
The purpose of the study is to determine the appropriate pediatric dosage and evaluate the pharmacokinetics (PK) and safety of Lutetium Lu 177 Edotreotide Targeted Radiopharmaceutical Therapy (RPT) as a monotherapy or following…
- Conditions
- Somatostatin Receptor Positive, NETs, Lymphoma, Solid Tumor
- Trial name
- KinLET (NCT06441331)
- Testing
- Lutetium Lu 177-Edotreotide, Amino Acid Solution
- Where
- 9 sites in United States, France and 1 more
- Volunteers
- 20 people
- Sponsor
- ITM Solucin GmbH
Malaria,Falciparum
Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.
This is a household randomized trial of a new tool for house modification, Insecticide-Treated Eave nets (ITENs) in combination with insecticide-treated window screens (ITWS), coated with a dual active ingredient (dual AI)…
- Trial name
- ITENs (NCT05125133)
- Testing
- ITENs + ITWS
- Where
- Tanzania
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Ifakara Health Institute
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda
The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance in mosquito populations to commonly used insecticides.
- Trial name
- NCT04230161
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Indoor residual spraying
- Where
- Rwanda
- Volunteers
- 3,502 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations.
- Trial name
- NCT04157894
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Piperonyl butoxide long-lasting insecticidal net
- Where
- Burkina Faso
- Volunteers
- 5,606 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
LLIN Evaluation in Uganda Project
In Uganda, the National Malaria Control Division (NMCD) and implementing partners plan to deliver long-lasting insecticidal nets (LLINs) nationwide in 2020-21, through a mass distribution campaign supported by generous…
- Trial name
- LLINEUP2 (NCT04566510)
- Testing
- long lasting insecticidal nets with alpha-cypermethrin + pyriproxyfen (PPF LLIN, Royal Guard)), long lasting insecticidal nets with deltamethrin + piperonyl butoxide (PBO LLIN, PermaNet 3.0)), Social behaviour change communication
- Where
- Uganda
- Volunteers
- 32,895 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Dengue
Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia. Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people…
- Conditions
- Malaria, Dengue, Japanese Encephalitis
- Trial name
- NCT00938379
- Testing
- 20% deet insect repellent
- Where
- Laos
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention
The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria…
- Trial name
- NCT01697852
- Testing
- Indoor residual spraying with bendiocarb, LLIN by universal coverage campaign
- Where
- Tanzania
- Volunteers
- 22,300 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Osteoporosis
A Study on Vertebral Bone Strength by Micro-CT-Like Image
In this study, we use conditional generation adversarial network to enhance the resolution of MSCT images and obtain micro-CT-like images.
- Trial name
- NCT04954417
- Testing
- Radiological scanning, Deep learning, Bio-mechanical testing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Childhood Cancer
Neutrophil Extracellular Traps Formation Post-hematopoietic Stem Cell Transplantation
Identifying the post-transplantation phase wherein neutrophils recover their ability to release NETs could shed new light on the mechanism responsible for the increased susceptibility to infection among these patients and aid in…
- Trial name
- NETs post HSCT (NCT01491230)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pediatric Solid Malignancies, Pediatric Hematological Malignancies
Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy and Their Role in Antitumor Activity
Examine neutrophil extracellular traps (NETs) formation, in relation to other neutrophil functions like chemotaxis, superoxide production, hydrogen peroxide production, and the presence of myeloperoxidase, in pediatric patients…
- Trial name
- NCT01533779
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Malaria, Falciparum
Preventing Malaria During Pregnancy in Epidemic-prone Areas.
The purpose of this study is to compare the efficacy and cost-effectiveness of three alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone area of low transmission in the East African…
- Trial name
- NCT00142207
- Testing
- Intermittent preventive treatment:sulphadoxine-pyrimethamine, Insecticide-treated mosquito bed net
- Where
- Uganda
- Volunteers
- 4,775 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Community Point Distribution of Insecticide Treated Bed Nets
All households in three zones in Zambia's Eastern Province were invited to attend a community point distribution of insecticide treated bed nets (ITNs).
- Trial name
- NCT02517879
- Testing
- Community point distribution, Community health worker hang-up visit
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- IDinsight
Malaria, Anaemia
Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition
Although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death.
- Trial name
- NCT01454752
- Testing
- Intermittent parasite clearance
- Where
- Senegal
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine