Clinical trials: Naltrexone
Anorexia Nervosa/Bulimia, Anorexia in Adolescence
Oral Naltrexone In Pediatric Eating Disorders
The objective of this study is to evaluate the effectiveness of oral naltrexone tablets in pediatric and adolescent eating disorders, in particular anorexia nervosa and bulimia nervosa, as compared to placebo.
- Conditions
- Anorexia Nervosa/Bulimia, Anorexia in Adolescence, Anorexia Nervosa, Atypical, Anorexia Nervosa, Binge Eating/Purging Type
- Trial name
- ONPED (NCT05073679)
- Testing
- Naltrexone Hydrochloride, Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rosemary Claire Roden
Moderate-severe Pain
Safety and Pharmacokinetic Study of ALO-02 in Children Ages 7-17 With Pain
Safety and pharmacokinetics of an abuse-deterrent, extended-release formulation of oxycodone hydrochloride with a sequestered naltrexone core in children 7-17 with moderate-severe pain.
- Trial name
- NCT02680847
- Testing
- ALO-02
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Pfizer
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Opioid-use Disorder
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDs-buprenorphine and injectable naltrexone-can be prescribed in primary care (PC).
- Trial name
- PROUD (NCT03407638)
- Testing
- PROUD Intervention
- Where
- 6 sites in United States
- Volunteers
- 377,373 people
- Sponsor
- Kaiser Permanente
Drug Dependence
Extended Release Naltrexone for Opioid-Dependent Youth
The purpose of this study is to compare 6-month treatment outcomes for 15-21 year old opioid-dependent youth receiving extended release naltrexone (XR-NTX) v. Treatment as Usual (TAU).
- Trial name
- NCT01843023
- Testing
- Extended Release Naltrexone, Psychosocial Treatment, Buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Friends Research Institute, Inc.
Eating Disorders, Binge Eating
Naltrexone Neuroimaging
The purpose of this open-label, pilot study is to evaluate fMRI as a biomarker of opioid antagonism in adolescents with ED. Modulation of brain activation will be examined in regions of interest by fMRI using a food-specific and…
- Conditions
- Eating Disorders, Binge Eating, Purging (Eating Disorders)
- Trial name
- EDIT-N2 (NCT04935931)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Mercy Hospital Kansas City
Crohn's Disease
The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's Disease
It is hypothesized that oral naltrexone will improve inflammation of the bowel by increasing endogenous enkephalin levels in subjects with active Crohn's disease.
- Trial name
- LDN-Ped (NCT00715117)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center