Clinical trials: Negative Surgical Margins
Growth Modification
Three-Dimensional Assessment of Dentoskeletal Changes Associated With a Modified Twin Block Appliance
The aim of the current study is to evaluate the skeletal, dental, soft tissue, TMJ, and upper airway size changes associated with a new design of twin block compared to the conventional twin block appliance.
- Trial name
- NCT06589206
- Testing
- modified design of twin block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malocclusion, Pain
Anxiety, Pain, and Quality of Life in Orthodontic Treatment
This study was evaluated anxiety, pain, and oral health-related quality of life in individuals treated with conventional fixed appliances (Group A) and clear aligners (Group B) for moderate malocclusion during the initial phase…
- Conditions
- Malocclusion, Pain, Anxiety, Quality of Life
- Trial name
- NCT06133296
- Testing
- Conventional fixed treatment, Clear aligner treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Inflammation, Oxidative Stress
Oxidative-reductive Processes and the Degree of Inflammation in Saliva With Conventional Brackets and Clear Aligners
The purpose of this prospective observational study is to evaluate the differences in oxidative-reductive processes and the degree of inflammation in saliva during treatment with conventional brackets and clear aligners.
- Conditions
- Inflammation, Oxidative Stress, TNF-α
- Trial name
- NCT06507592
- Testing
- Saliva samples collection
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Orthodontic Tooth Movement
GCF Volume Changes in Aligners and Fixed Appliances
Orthodontic tooth movement induces biological responses in periodontal tissues that can be reflected by changes in gingival crevicular fluid (GCF).
- Trial name
- GCF-OTM (NCT07480538)
- Testing
- Clear Aligner Therapy, Fixed Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Malocclusion, Narrow Maxilla
Clear Orthodontic Expander Versus Hyrax
This study will be conducted to evaluate the effectiveness of a clear expander fabricated from 2-mm biocompatible polyethylene terephthalate glycol (PETG) thermoforming material integrated with an expansion screw in achieving…
- Trial name
- COE-Hyarx (NCT07362160)
- Testing
- New clear expander, Hyrax expander
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Effect of Platelet Rich FibrinDuring Clear Aligner Therapy
Influence of Injectable Platelet Rich Fibrin on Different Orthodontic Tooth Movements During Clear Aligner Therapy
The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.
- Trial name
- NCT06380946
- Testing
- iPRF
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Malocclusion
Tunnel Attachments With Clear Aligners vs Clear Aligners
Incorporating wire threaded custom tunnel attachments with clear aligner therapy is a novel approach developed to address the shortcomings of the currently available orthodontic systems.
- Trial name
- NCT04130477
- Testing
- Tunnel attachments and light Nickel Titanium wire, Clear Aligner therapy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Harvard School of Dental Medicine
Gastric Residual Volume
Feasibility of 1 Hour Clear Fluid Fasting Prior to Paediatric GA
The study is aim to investigate the appropriate fasting time for clear fluid in paediatric patients who plan for elective minor surgery.
- Trial name
- NCT03952260
- Testing
- Fasting time for clear fluid prior to anaesthesia
- Where
- Malaysia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ma Tai Jiun
Clinical CT Abdomen/Pelvic With Oral Contrast and Sedation
CT Residual Gastric Fluid Volume
Hypothesis: The investigators hypothesize that more than 50% of the patients receiving enteric contrast material (ECM) < 2 hours of anesthesia/sedation would have residual gastric fluid volume (GFV) > 0.4 ml/kg.
- Trial name
- NCT02239068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fasting
Effect of Premedicant Oral Paracetamol on Gastric Volume and pH
Patients are asked to fast before general anaesthesia to reduce the risk that any gastric contents could be regurgitated and aspirated into the lungs once anaesthetised.
- Trial name
- NCT04625608
- Testing
- Paracetamol, Standard care
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Root Resorption
Root Resorption Accompanied Clear Aligners and Fixed Orthodontic Appliance
The aim of the study is to compare apical root resorption accompanied orthodontic treatment using clear aligners vs fixed appliances.
- Trial name
- NCT05232318
- Testing
- Leveling and alignment
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Pediculoses, Head Lice
Neem Lotion With Combing for Lice
This was a Phase IIa randomised, assessor blinded, parallel group study in which half the participants were treated with Nice 'n Clear neem-based conditioning lotion plus combing with a head louse detection and removal comb and…
- Trial name
- NCT02974088
- Testing
- Neem-based lotion plus louse comb, Neem-based lotion plus grooming comb
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Medical Entomology Centre
Fasting, Gastric Emptying
Comparison of Residual Gastric Volume Between Children Who Drink Different Clear Oral Fluid Volume
According to the American Society of Anesthesiologists (ASA) fasting guideline for patients undergoing elective surgery, the 2-hour fasting period is suggested for clear oral fluid (including water, pulp-free juice and tea or…
- Trial name
- NCT03741777
- Testing
- Clear oral fluid
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Malocclusion
The Use of Clear Aligners With Movement Enhancement Techniques
The purpose of this study is to use clear aligners to measure tooth movement and length of treatment.
- Trial name
- NCT02087163
- Testing
- Movement Enhancement Technique, Clear Aligner
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Align Technology, Inc.
Orthodontic Aligners
The Efficiency of Clear Aligners in Maxillary Molar Distalization: A Randomized Clinical Trial.
The aim of this study is to evaluate the accuracy of clear aligners on the amount of the maxillary molar distalization.
- Trial name
- Aligner (NCT06330571)
- Testing
- Molar distalization by aligners with attachment
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Malocclusion, Angle Class I
Predictability of Part-time Wearing of Removable Clear Aligner Therapy Versus Full Time
14 Patients with mild to moderate crowding and spacing will be selected according to inclusion criteria. Treatment planning will be done on Maestro® software. An impression will be taken and scanned by an extra-oral scanner.
- Trial name
- NCT06253286
- Testing
- clear aligner treatment for orthodontics patients
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Malocclusion of Anterior Teeth, Malocclusion in Children
Patient-Reported Outcomes for Different Orthodontic Thermoplastics Used in Clear Aligners
Clear aligner therapy is an esthetic orthodontic treatment modality that uses removable thermoplastic trays to correct dental alignment.
- Conditions
- Malocclusion of Anterior Teeth, Malocclusion in Children, Malocclusion Class II
- Trial name
- NCT07790315
- Testing
- Device / orthodontic clear aligner material
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Orthodontic Pathological Resorption of External Root, Complication of Personal Oral Hygiene
Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment
Orthodontic treatment has been traditionally carried out with fixed appliances involving the use of stainless steel brackets and archwires.
- Trial name
- RCT (NCT02745626)
- Testing
- Appliance
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- UConn Health
Clear Cell Renal Cell Carcinoma
Novel Biomarkers of Hypoxia and Metabolism in Clear Cell Renal Cell Carcinoma
Renal cell carcinoma (RCC) is one of the common malignant tumors in human beings and originates from the renal tubular epithelium. Clear cell renal cell carcinoma (ccRCC) is the main pathological type of RCC.
- Trial name
- NCT05214885
- Testing
- No intervention was required for patients or control group in this study
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Malocclusion
Class II Correction Study Using the Invisalign System
To demonstrate that growing teenagers which present up to full cusp Class II malocclusions can be treated using the Invisalign System.
- Trial name
- NCT02376829
- Testing
- Invisalign System
- Where
- 10 sites in United States, Canada
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Align Technology, Inc.