Clinical trials: Neonatal Mortality
Neonatal Sepsis, Neonatal Mortality Rate
Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth
Purpose of this study is determine if skin application of chlorhexidine at birth would reduce infection in infants weighing <1500 g at birth.
- Trial name
- CAPS (NCT01723501)
- Testing
- 0.25% chlorhexidine, sterile water
- Where
- 3 sites in India
- Sponsor
- All India Institute of Medical Sciences
Congenital Heart Surgery, Congenital Heart Defects
Death Following Congenital Heart Surgery
The purpose of this study is to elucidate the patterns of death following congenital heart surgery.
- Trial name
- NCT00215072
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Heart Defects, Congenital
Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients
Many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the…
- Trial name
- NCT02618707
- Testing
- Lactate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Maternal Mortality
Community Based Strategies to Reduce Maternal Mortality in Northern Nigeria
The objective of this cluster randomized controlled trial is to assess the impact of several community-based interventions that address the key factors underlying the high maternal mortality, as well as neonatal mortality and…
- Trial name
- NCT01487707
- Testing
- Voluntary Health Worker (VHW) Program, Safe Birth Kit, Community Folk Media Campaigns
- Where
- Nigeria
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Gastroschisis
Multi-Centre Gastroschisis Interventional Study Across Sub-Saharan Africa
This study is a multi-centre interventional study at seven tertiary paediatric surgery centres in Ghana, Zambia, Malawi and Tanzania aimed at reducing mortality from gastroschisis.
- Trial name
- NCT03724214
- Testing
- Pre-hospital interventional care bundle, In-hospital interventional care bundle
- Where
- 9 sites in Canada, Ghana and 4 more
- Volunteers
- 235 people
- Sponsor
- King's College London
Infectious Disease
Community Based Interventions to Reduce Neonatal Mortality in Bangladesh
This project delivers, promotes and facilitates services related to pregnancy, delivery and newborn care.
- Trial name
- NCT00198705
- Testing
- Improved management of severe neonatal infections
- Where
- Bangladesh
- Volunteers
- 10,670 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Sickle Cell Disease
Sickle Cell Clinical Research and Intervention Program
Despite the important work of previous sickle cell disease (SCD) cohort studies, there remain many understudied areas that require investigation.
- Trial name
- NCT02098863
- Where
- 6 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- St. Jude Children's Research Hospital
Asphyxia Neonatorum
Neonatal Resuscitation With Supraglottic Airway Trial
Mortality rates from birth asphyxia in low-income countries remain very high. Face mask ventilation (FMV) is the most common method of resuscitating neonates in such settings.
- Trial name
- NeoSupra (NCT03133572)
- Testing
- Supraglottic airway, Face-mask
- Where
- Uganda
- Volunteers
- 1,163 people
- Sponsor
- Centre For International Health
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiac Disease, Cardiac Surgery
Platelet Transfusion During Neonatal Open Heart Surgery
Hypothesis: Dilutional thrombocytopenia after cardiopulmonary bypass (CPB) is universal and administration of donor apheresis platelets just prior to termination of bypass will assist in early correction of coagulopathy, early…
- Conditions
- Cardiac Disease, Cardiac Surgery, Cardiopulmonary Bypass, Platelet Transfusion
- Trial name
- CPB (NCT03045068)
- Testing
- Platelet Transfusion, FFP and Cryoprecipitate, PRBC and cell saver Transfusion
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The University of Texas Health Science Center, Houston
Infant Mortality, Preterm Birth
Antenatal Micronutrient Supplementation and Infant Survival
The purpose of this community-based randomized trial is to examine whether a daily antenatal and postnatal multiple micronutrient supplement given to women will enhance newborn and infant survival and health and other birth…
- Conditions
- Infant Mortality, Preterm Birth, Low Birth Weight, Neonatal Mortality
- Trial name
- JiVitA-3 (NCT00860470)
- Testing
- Iron (27 mg) - folic acid (600 ug), Multiple micronutrient
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 44,567 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pregnancy Complications, Preterm Labor
Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda
The purpose of this study is to determine whether a combination of evidence-based strategies can improve intrapartum and newborn care in facilities to reduce mortality among preterm infants.
- Conditions
- Pregnancy Complications, Preterm Labor, PreTerm Birth, Stillbirth
- Trial name
- PTBi-KE-UG (NCT03112018)
- Testing
- data strengthening, modified Safe childbirth checklist - control, modified Safe childbirth checklist - enhanced
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 102,988 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sickle Cell Disease, Pain Crisis Recurrent
Effectiveness of Laying-on-of-hands for Sickle Cell Disease
The objective of this study is to evaluate the effectiveness of 1-year administration of laying-on-of-hands on the morbidity and mortality of patients with sickle cell disease in Africa.
- Conditions
- Sickle Cell Disease, Pain Crisis Recurrent, Anemia, Infection
- Trial name
- NCT01518218
- Testing
- laying-on-of-hands
- Where
- Democratic Republic of the Congo
- Volunteers
- 40 people
- Sponsor
- MOA Health Science Foundation
covid19 Infection, Pregnancy Complications
Covid-19 in Pregnancy: a French Population-based Cohort of Women and Newborns
The purpose of this study is to characterize the incidence and clinical features of the maternal COVID 19 infection, as well as the associated morbidity of the mother and the child, in the French context
- Conditions
- covid19 Infection, Pregnancy Complications, Neonatal Complications
- Trial name
- Coropreg (NCT04463758)
- Testing
- An auto-questionnaire comprising three psychometric scales
- Where
- France
- Volunteers
- 6,015 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatal Mortality
Newborn Kit to Save Lives in Pakistan
There are over 3 million annual neonatal deaths. Approximately 2/3 of neonatal deaths are due to infection, low birth weight (LBW), and prematurity.
- Trial name
- NCT02130856
- Testing
- Neonatal kit
- Where
- Pakistan
- Volunteers
- 8,518 people
- Sponsor
- The Hospital for Sick Children
Childhood Mortality
Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso
Although under-5 mortality rates are declining globally, neonatal mortality remains persistently high in many regions of sub-Saharan Africa.
- Trial name
- NAITRE (NCT03682653)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 21,832 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Transposition of the Great Arteries, Systemic Right Ventricle
Systemic Right Ventricle Long-term Outcome
Patients with the transposition of great arteries (TGA) who undergo atrial switch operation and congenitally corrected TGA (ccTGA) patients have the right ventricle as their systemic ventricle.
- Trial name
- SINCERE (NCT06258083)
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 542 people
- Sponsor
- University Medical Center Groningen
Early Neonatal Mortality
A Randomized Trial of Providing BCG Vaccination Immediately
Recent studies show that BCG vaccination reduces neonatal mortality by more than 40%. This effect cannot be explained by prevention of tuberculosis, which is very rare among infants.
- Trial name
- NCT01989026
- Testing
- BCG
- Where
- Guinea-Bissau
- Volunteers
- 3,361 people
- Sponsor
- Bandim Health Project