Clinical trials: Nephrolithiasis
Kidney Calculi (or Renal Calculi / Nephrolithiasis), Supine Mini Percutaneous Nephrolithotomy
Supine vs. Prone Mini-PCNL in Children
Percutaneous nephrolithotomy (PCNL) is an established intervention for large or ESWL-resistant renal stones in pediatric populations.
- Conditions
- Kidney Calculi (or Renal Calculi / Nephrolithiasis), Supine Mini Percutaneous Nephrolithotomy, Prone Mini Percutaneous Nephrolithotomy
- Trial name
- SUPRO-PED (NCT07887945)
- Testing
- Group A, Group B
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Fayoum University Hospital
Nephrolithiasis, Kidney Stone
Observational Approach Versus Surgical Intervention for Stones
The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to upfront surgery results in less healthcare-related life disruption due…
- Trial name
- OASIS (NCT07718802)
- Testing
- Surgery, Observation
- Where
- 4 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Children's Hospital of Philadelphia
Renal Stone, Pediatric
Flexible Ureteroscopy Versus Mini- Percutaneous Nephrolithotomy in Management of Pediatric Renal Stones Less Than 2 cm
This single-center, prospective, two-arm randomized controlled trial included 58 patients younger than 18 years who were allocated 1:1 to Mini-PCNL or FURS between June 2023 and December 2024.
- Trial name
- NCT07870200
- Testing
- Group A :Flexible ureteroscope group, Group B : Mini perc group
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elsayed Abdelhalim Elsayed
Mini Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery
Mini Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery for Pediatric Renal Stones (10-30 mm)
This work aimed to compare the safety and efficacy of retrograde intrarenal surgery using single-use flexible ureteroscopy (FURS) with mini-percutaneous nephrolithotomy (PCNL) in children with renal stones measuring 10-30 mm.
- Conditions
- Mini Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery, Pediatric, Renal Stones
- Trial name
- NCT07836192
- Testing
- Mini percutaneous nephrolithotomy, Flexible ureteroscopy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Nephrolithiasis, Pediatric Nephrolithiasis
Tubeless vs Tube PCNL in Pediatric Nephrolithiasis
This study is designed to compare two surgical techniques for removing kidney stones in children and adolescents (ages 6-18 years).
- Trial name
- TUBELESS (NCT07183930)
- Testing
- Tubeless Percutaneous Nephrolithotomy (PCNL), Standard Tube Percutaneous Nephrolithotomy (PCNL)
- Where
- Pakistan
- Volunteers
- 640 people
- Sponsor
- Lady Reading Hospital, Pakistan
Kidney Calculi
Flexible Ureteroscopy for Large Renal Stones in Children
This prospective single-arm interventional study evaluated the efficacy and safety of flexible ureteroscopy for the treatment of large renal stones measuring 2 cm or more in pediatric patients.
- Trial name
- NCT07780409
- Testing
- Flexible Ureteroscopic Stone Disintegration
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Autosomal Dominant Hypocalcemia (ADH)
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
The primary purpose of the study is to understand the effectiveness, safety, and tolerability of encaleret when compared to standard of care (SoC) treatment in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1).
- Trial name
- CALIBRATE (NCT05680818)
- Testing
- Encaleret, Standard of Care
- Where
- 25 sites in United States, Australia and 8 more
- Volunteers
- 67 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Pediatric Urolithiasis, Kidney Stone
Standard Versus Flexible and Navigable Suction Ureteral Access Sheath in Pediatric Flexible Ureterorenoscopy for Renal Stones < 2 cm
This randomized controlled trial aims to compare the efficacy and safety of a Flexible and Navigable Suction Ureteral Access Sheath (FANS) versus a standard ureteral access sheath during flexible ureterorenoscopy (FURS) in…
- Conditions
- Pediatric Urolithiasis, Kidney Stone, Nephrolithiasis
- Trial name
- FANS-UAS (NCT07689565)
- Testing
- Standard Ureteral Access Sheath (Boston Scientific)., Flexible and Navigable Suction UAS (ClearPetra).
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Autosomal Dominant Hypocalcemia
ADH1 and ADH2 Disease Monitoring Study (DMS)
A global, multi-center, Disease Monitoring Study (DMS) in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1) or Autosomal Dominant Hypocalcemia Type 2 (ADH2) designed to characterize ADH1 and ADH2 disease…
- Trial name
- CLARIFY (NCT05227287)
- Where
- 27 sites in United States, Australia and 11 more
- Volunteers
- 95 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Renal Stones, Calculus
Comparison of ESWL and Mini-PCNL for High-Density Renal Stones in Children
Pediatric nephrolithiasis is an increasing health problem, with rising prevalence particularly in certain geographic regions. Management options for pediatric renal stones include extracorporeal shockwave lithotripsy (SWL)…
- Conditions
- Renal Stones, Calculus, Pediatric, Endoscopy
- Trial name
- NCT07360041
- Testing
- Miniaturized Percutaneous Nephrolithotomy (mini-PNL), Shock Wave Lithotripsy (SWL)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Calculi, Renal, PCNL
Preoperative Prophylactic Fosfomycin Trometamol Versus 5-day Levofloxacin in Prevention of Postpercutaneous Nephrolithotomy Infectious Complications and Sepsis.
A randomized controlled trial comparing the use of preoperative prophylactic single dose fosfomycin trometamol versus levofloxacin in prevention of post-PCNL infectious complications and sepsis.
- Conditions
- Calculi, Renal, PCNL, Infectious Complications
- Trial name
- NCT07355907
- Testing
- PCNL
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Tanta University
Nephrolithiasis, Kidney Calculi
Comparison Between Supine Mini-PCNL and Flexible Ureteroscopy (FURS) for Dense Lower Calyceal Stones (1-2 cm) in School-Age Pediatric Patients
This randomized controlled clinical study compared supine mini percutaneous nephrolithotomy versus flexible ureteroscopy for the management of dense lower calyceal renal stones measuring 1-2 centimeters (≤20 millimeters) with…
- Conditions
- Nephrolithiasis, Kidney Calculi, Urolithiasis
- Trial name
- NCT07345234
- Testing
- Supine Mini Percutaneous Nephrolithotomy, Flexible Ureteroscopy
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Nephrolithiasis
Is CYP24A1 Heterozygosity a Risk Factor for Nephrolithiasis?
Biallelic loss-of-function variants in CYP24A1 have been identified as a common genetic cause of autosomal recessive hypercalcemia (ARH, ORPHA 300547, 1 in 80,000 live births), characterized by low PTH (parathyroid hormone)…
- Trial name
- HETEROCYP (NCT07201701)
- Testing
- Supplementary blood samples for PBMC analysis at V2
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Stone;Renal
Flexible Ureteroscopy Versus Mini-Percutaneous Nephrolithotomy for Treatment of Renal Stones
Management of nephrolithiasis is evolving rapidly, and various minimally-invasive urological procedures are currently available for treating patients with renal stones, including extracorporeal shockwave lithotripsy (ESWL)…
- Trial name
- NCT03932370
- Testing
- Flexible ureteroscopy, mini-Percutaneus nephrolithotomy
- Where
- Egypt
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Assiut University
Renal Stones, Pediatric Renal Stones
Retrograde Intrarenal Surgery for Renal Stones in Pediatrics: A Prospective Analysis of Feasibility and Outcomes.
it is an interventional single arm study for treating pediatric renal stones≤2cm by FURS and Holmium laser fragmentation.pediatric groups is benig compared for stone free rate, complication rate , success rate.
- Trial name
- RIRS pediatric (NCT07089394)
- Testing
- flexible urs
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Kidney Stones, Urolithiasis
Evaluation of Stone Composition in Surgical Kidney Stone Patients in Vietnam
This is a prospective observational study conducted at Binh Dan Hospital, Ho Chi Minh City, Vietnam, from July to December 2023.
- Conditions
- Kidney Stones, Urolithiasis, Nephrolithiasis
- Trial name
- STONE-VN (NCT07038954)
- Testing
- Stone Composition Analysis
- Where
- Vietnam
- Volunteers
- 222 people
- Sponsor
- Binh Dan Hospital
Nephrolithiasis, Urinary Tract Infection (UTI)
Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2
This study will be a multi-institutional randomized clinical trial of a short course of pre-operative antibiotic prophylaxis in addition to perioperative antibiotics prior to undergoing percutaneous nephrolithotomy.
- Conditions
- Nephrolithiasis, Urinary Tract Infection (UTI), Sepsis
- Trial name
- PNLABXPART2 (NCT02829060)
- Testing
- Nitrofurantoin 100 MG, 7d, Gentamicin, 5mg/kg, Ampicillin 2g
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, San Diego
Renal Stones, Urolithiasis, Calcium Oxalate
Comparison of Trifecta Analysis of Standard Versus Mini Percutaneous Nephrolithotomy in the Management of Urolithiasis
Introduction: Urolithiasis is a common urological condition, and percutaneous nephrolithotomy (PCNL) is a widely used treatment option.
- Trial name
- Trifecta (NCT06836700)
- Testing
- Mini PCNL
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Renal Stone
Flexible Mini Percutaneous Nephrolithotomy Vs Retrograde Intra-renal Surgery
The use of flexible ureteroscopy and minimally-invasive percutaneous techniques, which utilize smaller tract sizes, has been established as a way to decrease the invasiveness of procedures and improve patient outcomes compared to…
- Trial name
- NCT06249100
- Testing
- flexible mini percutaneous nephrolithotomy, Retrograde intrarenal surgery
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Renal Stone, Kidney; Complications
Evaluation of Renal Oxygenation by NIRS in Pediatric Endourologic Stone Surgery
The study aims to compare renal oxygenation levels in retrograde intrarenal surgery (RIRS) and ureteroscopy (URS) procedures with a control group.
- Conditions
- Renal Stone, Kidney; Complications, Ureter Stone, Renal Oxygenation
- Trial name
- NCT06110247
- Testing
- NIRS, Taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- Ankara City Hospital Bilkent