Clinical trials: Nephropathy
Cardiac Arrest
Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906.
- Trial name
- PIVOT (NCT00358579)
- Testing
- Adrenaline, Vasopressin
- Where
- 4 sites in Singapore
- Volunteers
- 727 people
- Sponsor
- Singapore General Hospital
Rare Kidney Stone Diseases
Monogenic Kidney Stone - Genetic Testing
This study will attempt to identify the specific gene (coded in the DNA) and changes (mutations) within that gene that are the cause of monogenic kidney stone disease.
- Trial name
- NCT03305835
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Mayo Clinic
Chronic Kidney Disease; Iron Deficiency Anemia
A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)
Primary Objectives: To evaluate the safety (compared to iron sucrose) and efficacy of ferumoxytol in pediatric CKD subjects with iron deficiency anemia (IDA) or who are at risk of development of IDA Secondary Objective: To…
- Trial name
- NCT03619850
- Testing
- Ferumoxytol, Iron sucrose
- Where
- 21 sites in United States, Hungary and 3 more
- Volunteers
- 129 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Steroid-Dependent Nephrotic Syndrome
Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab Among Children With Steroid Dependent Nephrotic Syndrome
The aim of the RITURNS II study is to evaluate the efficacy and safety of Repeat courses of Rituximab to that of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 24 months among…
- Trial name
- RITURNS II (NCT03899103)
- Testing
- Rituximab, Mycophenolate Mofetil
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Nilratan Sircar Medical College
Chronic Kidney Diseases Receiving Anticoagulants
Frequency and Risk Factors of Bleeding in Patients With Chronic Kidney Disease Receiving Anticoagulants
1-Introduction: Chronic kidney disease (CKD) is a significant global public health issue, closely linked to cardiovascular disease (CVD).
- Trial name
- NCT06543927
- Testing
- serum creatinine, INR
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT.
- Trial name
- SAVE (NCT06517810)
- Testing
- QUELIMMUNE (SCD-PED)
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- SeaStar Medical
Autosomal Dominant Polycystic Kidney Disease
NOX4 and Related Biomarkers in ADPKD
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT04630613
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Wolfram Syndrome
Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome
This trial aims to investigate the efficacy, safety and tolerability of sodium valproate in the treatment of patients with Wolfram syndrome.
- Trial name
- NCT03717909
- Testing
- Sodium Valproate 200Mg E/C Tablet
- Where
- 6 sites in France, Poland and 2 more
- Volunteers
- 63 people
- Sponsor
- University of Birmingham
Kidney Disease, Nephrotic Syndrome
Immune System Related Kidney Disease
Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders.
- Trial name
- NCT00001979
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Kidney Disease, Hypertension
Group-based Chronic Kidney Disease Care
A two-group randomized clinical trial testing whether group-based care is feasible and will help improve blood pressure control in adult and adolescent patients with chronic kidney disease and hypertension.
- Trial name
- NCT02467894
- Testing
- Group-based Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Albert Einstein College of Medicine
Nephrotic Syndrome
Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome
The purpose of this study is to investigate if lymphocyte markers predict response to rituximab among patients with idiopathic nephrotic syndrome
- Trial name
- NCT03501459
- Testing
- Rituximab
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Health System, Singapore
Idiopathic Nephrotic Syndrome
A National Prospective Cohort of Patients With Idiopathic Nephrotic Syndrome Beginning in Childhood.
Pediatric idiopathic nephrotic syndrome (INS) is a rare disease for which the optimal therapeutic strategy has not yet been defined.
- Trial name
- PIN'SNP (NCT04207580)
- Testing
- Inclusion and follow up of pediatric patients with an idiopathic nephrotic syndrome,
- Where
- 48 sites in France, Reunion
- Volunteers
- 1,180 people
- Sponsor
- University Hospital, Limoges
Refractory Lupus Nephritis, Systemic Sclerosis
CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
This is a single-center, open-label, non-randomized, single-arm clinical trial. Patients with refractory lupus neritis (SLE-LN), systemic sclerosis (SSc), primary Sjogren syndrome combined with pulmonary artery hypertension…
- Conditions
- Refractory Lupus Nephritis, Systemic Sclerosis, Primary Sjogren's Syndrome Combined With Pulmonary Hypertension, Other Autoimmune Diseases (AID)
- Trial name
- NCT06947460
- Testing
- CD19-BCMA CAR-T cells infusion
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Beijing GoBroad Hospital
Renal Insufficiency, Acute
NIRS for the Diagnosis and Prevention of Acute Renal Failure
This prospective study will take place at Hotel Dieu de France hospital in Lebanon. One hundred children undergoing cardiac surgery for congenital heart disease between May 2020 and May 2021 will be included.
- Trial name
- NCT04605705
- Testing
- Optimization of the cardiac output, the temperature, the hemoglobin in order to have the NIRS value by up to 80%.
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Saint-Joseph University
Chronic Renal Failure, Hemodialysis
Effect of Malnutrition on the Prognosis in Hemodialysis Patients
The purpose of this study is to examined the effect of malnutrition and/or inflammation on atherosclerosis and prognosis in hemodialysis.
- Conditions
- Chronic Renal Failure, Hemodialysis, Malnutrition
- Trial name
- NCT00307983
- Where
- 2 sites in Japan
- Volunteers
- 600 people
- Sponsor
- University of Shizuoka
Acute Renal Insufficiency
Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics
Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially…
- Trial name
- CANOPY (NCT02955979)
- Testing
- CT scan with iodinated contrast agents
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Kidney Diseases
Ferric Citrate and Chronic Kidney Disease in Children
We will conduct a 12-month, double-blind, randomized, placebo-controlled trial to assess the effects of therapy with ferric citrate (FC) on changes in intact FGF23 levels (iFGF23, primary endpoint) in 160 pediatric patients (80…
- Trial name
- FIT4KID (NCT04741646)
- Testing
- Ferric Citrate
- Where
- 20 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- University of California, Los Angeles
Proteinuria, Kidney Diseases
Effects of Traditional Chinese Medicine (GSJYF) in Children With Inherited Proteinuric Kidney Disease
The purpose of this study is to determine whether traditional Chinese medicine, Gu Shen Juan Yu Formula, as complementary treatment is safe and effective in the treatment of Inherited Proteinuric Kidney Disease.
- Conditions
- Proteinuria, Kidney Diseases, Hereditary Nephropathy
- Trial name
- NCT05759754
- Testing
- TCM+ Routine Therapy, Routine Therapy
- Where
- 9 sites in China
- Volunteers
- 72 people
- Sponsor
- Children's Hospital of Fudan University
Type 1 Diabetes
Alpha-lipoic Acid in Diabetic Nephropathy
Endothelial dysfunction in diabetes is a central event in the pathogenesis of different microangioapthic changes. Nephropathy in patients with type 1 diabetes is a severe microvascular complication.
- Trial name
- NCT06253429
- Testing
- Thioctic Acid 333 MG Oral Capsule, Captopril 25Mg Tab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Acute Kidney Injury
Algorithm for Oliguria in Septic Shock
Acute Kidney Injury (AKI) develops in 88% to 30% of critically ill patients admitted to an intensive care unit and is a strong predictor of mortality.Therefore any management strategy that prevents progression of renal risk to…
- Trial name
- AMOSS (NCT02338895)
- Testing
- Ultrasound
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
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