Clinical trials: Nephrotic Syndrome
Nephrotic Syndrome in Children
The Effect of Self-Efficacy Promoting Program Using Computer Game on Proteinuria in Thai Children With Nephrotic Syndrome
Nephrotic syndrome is a medical condition where the kidneys release substantial amounts of protein into the urine, resulting in various issues such as tissue swelling and an increased susceptibility to infections.
- Trial name
- NCT06524986
- Testing
- Self-efficacy promoting program using computer game, Standard nursing care
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Nephrotic Syndrome
Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East
Nephrotic syndrome (NS) represents one of the most common diagnoses in pediatric and adult nephrology, with a prevalence of 16 per 100,000 children and 3 per 100,000 adults in Western countries.
- Trial name
- NCT03326037
- Testing
- Genotyping of the NPHS2 variant rs61747728
- Where
- Kuwait
- Volunteers
- 150 people
- Sponsor
- AHMED ABDULQADER HAMMOUDA ABOU SHALL
Primary Focal Segmental Glomerulosclerosis
FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)
This is a multicenter, open label, randomized study investigating two dose titration regimens of CXA-10 in subjects at least 18 years of age with primary FSGS.
- Trial name
- NCT03422510
- Testing
- CXA-10
- Where
- 24 sites in United States
- Volunteers
- 33 people
- Sponsor
- Complexa, Inc.
Nephrotic Syndrome
Effectiveness of Educational Gamified Cards About Nephrotic Syndrome
This study aims to evaluate the effectiveness of educational innovative gamified cards about nephrotic syndrome for school age children on their outcomes and caregivers' practices
- Trial name
- NCT05904197
- Testing
- Gamified Cards about Nephrotic Syndrome
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Glomerulonephritis, Nephrotic Syndrome
Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis
This study will test the safety and effectiveness of a monthly dosing regimen of dexamethasone-a strong steroid medication-to treat patients with focal segmental glomerulosclerosis (FSGS).
- Trial name
- NCT00004990
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Idiopathic Nephrotic Syndrome
Factors of Steroid Dependency in Idiopathic Nephrotic Syndrome
The primary purpose of the study is to identify the factors of steroid dependency in childhood idiopathic nephrotic syndrome. The steroid dependency is defined by a relapse of nephrotic syndrome within the 3 weeks that follow the…
- Trial name
- NEPHROVIR-2 (NCT01609426)
- Testing
- DNA chip dedicated to the pharmacogenetic of steroids
- Where
- France
- Volunteers
- 351 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Focal Segmental Glomerulosclerosis, Nephrotic Syndrome
Cardiomyopathy in Steroid-resistant Nephrotic Syndrome: Impact of Focal Segmental Glomerulosclerosis
The objective of this study is as follows: Perform genetic analysis to define the prevalence of each of the known gene mutations in an unselected cohort of patients with focal segmental glomerulosclerosis (FSGS) Perform a…
- Conditions
- Focal Segmental Glomerulosclerosis, Nephrotic Syndrome, Steroid Resistant Nephrotic Syndrome, Chronic Kidney Disease
- Trial name
- NCT00883636
- Testing
- Cardiovascular Assessment, Renal Assessment, Genetic Evaluation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwell Health
Nephrotic Syndrome
Diagnostic and Prognostic Value of Miss-1 Study in Children and Adult With Nephrotic Syndrome MISSNEPHROTIQUE
The nephrotic syndrome is a rare disease defined by a proteinuria >3g/24h and a hypoalbuminemia < 30g/L. Genetic and immune are the main causes.
- Trial name
- MISS-N (NCT03592030)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nephrotic Syndrome
Multitarget Strategy for Primary Podocytopathies
The goal of this clinical trial is to verify whether a cell culture system can be used to evaluate the presence of a factor capable of causing proteinuria in the serum of patients with primary podocytopathies.
- Trial name
- PODO-TARGET (NCT06718894)
- Testing
- Biologic fluid sampling
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Steroid Dependent and Frequent Relapsing Nephrotic Syndrome
Cyclosporine Adverse Outcomes in Steroid Dependent and Frequent Relapsing Nephrotic Syndrome in Children;Single Center Study
Nephrotic syndrome (NS) is the most common glomerular disorder in children with significant morbidity and mortality and affects about 1-3 per 100,000 children aged below 16 years.
- Trial name
- NCT05588869
- Testing
- observation of the adverse outcomes of Cyclosporine in steroid dependent and frequent relapsing nephrotic syndrome in children
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Nephrotic Syndrome
Role of PACAP in Nehprotic Syndrome
This study will identify the role of PACAP (pituitary adenylate cyclase-activating polypeptide) deficiency in patients with nephrotic syndrome.
- Trial name
- NCT01411982
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn's Disease, Nephrotic Syndrome
Glucocorticoid-induced Osteopenia in Children
The purpose of this study is to characterize the skeletal deficits and risk factors for impaired skeletal development in children requiring glucocorticoid therapy.
- Trial name
- NCT00289328
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Nephrotic Syndrome
Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood
The purpose of this study is to describe the hormones controlling fluid balance in pediatric patients with nephrotic syndrome. Further more, an analysis of the urinary and plasma proteins will be done using proteomics.
- Trial name
- NCT00690586
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Aarhus University Hospital
Nephrotic Syndrome
From Immune System Damage to Podocyte Cell Damage: Prospective Database and Biological Collection of Patients (Children and Adults) With MGLS and HSFP
Idiopathic Nephrotic Syndrome (INS) is a kidney disease characterized by massive proteinuria and hypoalbuminemia. It includes two anatomopathological entities: nephrotic syndrome with minimal glomerular lesions (SNLGM) and…
- Trial name
- BiobankSNI (NCT04174066)
- Testing
- blood sample, tissue sample, excreta
- Where
- 2 sites in France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Membranous Glomerulonephritis, Lupus Membranous Nepropathy
Sirolimus Therapy for Idiopathic and Lupus Membranous Nephropathy
This study will evaluate the safety and effectiveness of a new immunosuppressive drug, sirolimus, in reducing the amount of protein in the urine in patients with membranous nephropathy.
- Trial name
- NCT00050713
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Glomerular Disease, Minimal Change Disease
KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis
Glomerulonephritis (GN) generates an enormous individual and social economic burden. However, the therapeutic options are largely based on clinical and pathological parameters and the individual response to therapy or prognosis…
- Conditions
- Glomerular Disease, Minimal Change Disease, IgA Nephropathy, Membranous Nephropathy
- Trial name
- KORNERSTONE (NCT03929887)
- Testing
- Kidney Biopsy
- Where
- 6 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seoul National University Hospital
Nephrotic Syndrome, Adolescent
The Selection of Initial Treatment Regimens for Adolescent Nephrotic Syndrome.
Given that the treatment strategy for adolescent PNS has a significant impact on growth and development, but there are few cases and a lack of clinical research, this study plans to collaborate with several domestic top-tier…
- Conditions
- Nephrotic Syndrome, Adolescent, Biopsy
- Trial name
- NCT07071597
- Testing
- Renal Biopsy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Children's Hospital
Focal Segmental Glomerulosclerosis, Minimal Change Disease
Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease
The morbidity of recurrence of focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) after transplant is well-recognized and include contemporary reduction in quality of life, edema, early graft loss and…
- Conditions
- Focal Segmental Glomerulosclerosis, Minimal Change Disease, FSGS, MCD
- Trial name
- RESOLVE (NCT05650619)
- Testing
- Biospecimen collection, Data collection
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Idiopathic Nephrotic Syndrome
Short-term gluCOCOrticoid in Adult STEROID-sensitive Nephrotic Syndrome: The COCO-ASTEROID Study
This study will compare a short-term course (12 week) glucocorticoid regimen with the Conventional 24-week regimen as originally proposed by KDIGO.
- Trial name
- NCT07151456
- Testing
- Conventional 24-week glucocorticoid regimen, short-term course (12 week) glucocorticoid regimen
- Where
- China
- Volunteers
- 224 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Focal Segmental Glomerulosclerosis, Minimal Change Disease
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
To evaluate the safety, efficacy and tolerability of sparsentan oral suspension and tablets, and assess changes in proteinuria after once-daily dosing over 108 weeks.
- Conditions
- Focal Segmental Glomerulosclerosis, Minimal Change Disease, Immunoglobulin A Nephropathy, IgA Vasculitis
- Trial name
- EPPIK (NCT05003986)
- Testing
- Sparsentan
- Where
- 47 sites in United States, Germany and 6 more
- Volunteers
- 67 people
- Sponsor
- Travere Therapeutics, Inc.